جست‌وجوی استاد و پژوهشگر

Nicolas Rodrigueمشاهده پروفایل

دانشیار

• Molecular Evolution
• Bayesian Statistics
• Computational Biology
• +۳ مورد دیگر

Nicolas Rodrigue is an Associate Professor in the Department of Biology at Carleton University, with a cross appointment in Biology. He holds degrees from Bishop's University (BA), McGill University (BSc), École de technologie supérieure (MSc), and Université de Montréal (PhD). His research focuses on Bayesian modeling of molecular evolution, particularly protein-coding genes and evolutionary forces like mutation, selection, and drift. He also explores Markov chain Monte Carlo methods, protein structure modeling, and next-generation sequencing for viral/microbial evolution studies. Education: BA, Bishop's University BSc, McGill University MSc, École de technologie supérieure PhD, Université de Montréal Research Interests: Bayesian phylogenetic models Mutation-selection dynamics Protein sequence and structural evolution High-performance statistical computing Microbial genomics and clinical evolution Recent publications highlight advancements in phylogenetic modeling, adaptive evolution detection, and computational methods for analyzing molecular data. His work integrates statistical frameworks with evolutionary biology to address complex questions about genomic adaptation and sequence evolution. Awards: None explicitly listed. Advising/Grants: No student advising or grant details provided in the text. Lab/Teams: No specific lab or team affiliations mentioned.

• Microbial Synthetic Metabolism
• Metabolic Engineering
• Synthetic Biology
• +۴ مورد دیگر

Nico J. Claassens is an Associate Professor at the Laboratory of Microbiology, Wageningen University. His research focuses on microbial synthetic metabolism, including engineering metabolism and synthetic cells using multiplex genetic engineering and quantitative proteomics. He leads the Microbial Synthetic Metabolism group, which develops sustainable bioproduction strategies using CO2 and one-carbon substrates (e.g., formate, methanol) to produce food proteins and other bio-based products. Claassens received his PhD from Wageningen University (2017) and was a Postdoctoral Fellow at the Max Planck Institute (2017–2019), supported by a Rubicon Fellowship from NWO. He became an Assistant Professor at Wageningen in 2020 and was promoted to Associate Professor in 2023. Key research interests include synthetic biology, autotrophic growth pathways, and genome-scale engineering. He holds leadership roles: Associate Editor of Microbial Cell Factories , board member of the Dutch Biotechnology Association, and co-founder of SynBioNL. Awards include the NWO-Veni Grant (2019) and the NVBMB Prize (2022). Claassens teaches synthetic biology and advises the startup Farmless. His lab collaborates on national programs like Building A Synthetic Cell (BaSyC) and contributes to Wageningen Young Academy initiatives. Major achievements include pioneering the reductive glycine pathway for CO2 utilization and developing methods like the SIBR-Cas genome-editing system. His work bridges fundamental research (e.g., synthetic cell design) and applied biotechnology (e.g., food protein production from sustainable feedstocks).

• Adeno-Associated Virus (AAV) Vector Technology
• Gene Therapy
• MicroRNA Therapeutics
• +۳ مورد دیگر

Jun Xie is an Associate Professor at the UMass Chan Medical School and holds multiple positions in departments including the Gene Therapy Center , Genetic and Cellular Medicine , and Microbiology . His research focuses on adeno-associated virus (AAV) vector technology and AAV-mediated miRNA therapeutics , with applications in gene therapy for diseases like osteoporosis, spinal muscular atrophy, and fibrodysplasia ossificans progressiva. BS in Plant Genetics & Breeding from Huazhong Agricultural University, China MS in Molecular Biology & Biochemistry from Huazhong Agricultural University, China PhD in Genetics from Sun Yat-sen University of Medical Sciences, China Xie's recent work explores CRISPR/Cas9 genome editing delivered via AAV vectors, including studies on bone disease treatment (osteogenesis imperfecta, alveolar bone loss), neurological disorder therapies (spinal muscular atrophy), and immune-evasive AAV designs . His publications emphasize vector engineering to improve safety, targeting specificity, and therapeutic efficacy. Key trends in his 15 most recent articles include AAV serotype optimization (e.g., AAV5, AAV9), adenine base editing with engineered Cas9 variants, and miRNA-based interventions for metabolic and inflammatory conditions. His work spans preclinical rhesus monkey models and translational gene therapy applications .

• Biocatalysis
• Protein Engineering
• Non-Canonical Amino Acids
• +۵ مورد دیگر

Ivana Drienovska is an Assistant Professor in the Department of Chemistry and Pharmaceutical Sciences at the Faculty of Science, Vrije Universiteit Amsterdam . She also holds an affiliation with AIMMS (likely a research institute or program). Her research focuses on biocatalysis, protein engineering, and artificial enzyme design , with a particular emphasis on non-canonical amino acids, genetic code expansion, and functional group diversity in enzymes. She explores applications in sustainable chemistry, enzyme stabilization, and novel catalytic mechanisms. Recent work includes designing protein scaffolds for iminium biocatalysis, stabilizing protein complexes via covalent bicyclization, and incorporating functional secondary amines via genetic code expansion. Her studies often involve structural biology approaches (e.g., crystallography) and synthetic biology techniques. Affiliations : Faculty of Science (VU Amsterdam), AIMMS Courses Taught : Biocatalysis for a Sustainable Future, Bioorganic Chemistry, Concepts in Chemical Biology Key Research Themes : Engineering enzymes for novel functionalities (e.g., unnatural amino acids) Development of artificial metalloenzymes for asymmetric catalysis Structural and biochemical analysis of cold-adapted and extremophilic enzymes Lab/Team : Her group works at the interface of chemical biology, enzymology, and synthetic biology, focusing on creating next-generation biocatalysts for industrial and environmental applications.

• RNA Therapeutics
• Oligonucleotide Drug Development
• Neurodegenerative Diseases
• +۳ مورد دیگر

Anastasia Khvorova is a Professor and Remondi Family Chair in Biomedical Research at UMass Chan Medical School, holding primary appointments in the RNA Therapeutics Institute within the T.H. Chan School of Medicine. She maintains extensive cross-appointments across the Morningside Graduate School of Biomedical Sciences in departments including Biochemistry and Molecular Biotechnology, Neuroscience, and the RNA Therapeutics and Biology Program. Education: BS in Biology, Moscow State University MS in Molecular Biology, Moscow State University PhD in Biochemistry, Russian Academy of Sciences Professor Khvorova's research focuses on RNA therapeutics development , specializing in oligonucleotide chemistry, siRNA design, and delivery systems for neurological and genetic disorders. Her laboratory pioneers chemically modified self-delivering RNAi compounds targeting Huntington's disease, ALS, and Alzheimer's, with emphasis on overcoming delivery barriers through novel backbone chemistries and conjugate strategies. Current work explores divalent siRNA scaffolds for enhanced CNS penetration and multi-gene modulation. Analysis of her 15 most recent publications reveals dominant themes in siRNA chemical optimization (backbone/ribose modifications), neurological disease targeting (Huntington's, ALS, MECP2 disorders), and delivery innovation (extended nucleic acid backbones, albumin-binding constructs). Key advances include preventing oligonucleotide neurotoxicity via cation formulation and achieving single-dose therapeutic effects in mouse models. Awards and recognition: Rosalind Franklin Society Award for Nucleic Acid Therapeutics (2023) Remondi Family Chair in Biomedical Research Her laboratory actively recruits postdoctoral fellows for projects in RNAi preclinical development, medicinal chemistry, and small RNA trafficking, collaborating with Victor Ambros, Silvia Corvera, and UMASS imaging groups. Current grants support work on Huntington's disease somatic instability, SOD1 silencing for ALS, and MECP2-targeted therapies. The lab emphasizes interdisciplinary training in nucleic acid chemistry, pharmacology, and preclinical development. Professor Khvorova leads a dynamic research team within the RNA Therapeutics Institute, utilizing advanced imaging, mass spectrometry, and in vivo modeling to develop next-generation oligonucleotide therapeutics. Her work bridges fundamental RNA biology with translational applications, particularly for orphan neurological indications with unmet therapeutic needs.

Jeff Collerمشاهده پروفایل

استاد

• mRNA stability
• translation elongation
• RNA therapeutics
• +۳ مورد دیگر

Jeff Coller is the Bloomberg Distinguished Professor of RNA Biology and Therapeutics at Johns Hopkins University. His primary affiliation is with the Whiting School of Engineering and the Johns Hopkins School of Medicine, within the Department of Biomedical Engineering. He holds a PhD in Cellular and Molecular Biology from the University of Wisconsin and completed postdoctoral training at the Howard Hughes Medical Institute, University of Arizona. Previously, he was Director of the RNA Center at Case Western Reserve University and held the Henry Willson Payne Distinguished Professorship. Research Focus: Coller's lab investigates mRNA stability and translation, particularly how mRNA sequence features like codon optimality influence gene expression. His work bridges fundamental biology and translational medicine, with a focus on RNA-based therapies. He co-founded Tevard Biosciences and WyveRNA Therapeutics, which focus on RNA therapeutics. His research has been cited over 6,000 times and led to several patents in RNA-based therapies. Education: PhD in Cellular and Molecular Biology, University of Wisconsin; Postdoc at HHMI, University of Arizona Labs/Teams: Coller Lab (Johns Hopkins University) Grants/Funding: Not explicitly detailed, but implied via patent activity and industry partnerships Key Contributions: Demonstrated that mRNA sequence features directly influence stability and translation efficiency. Pioneered understanding of codon optimality's role in mRNA fate. Co-developed novel RNA-based therapeutics.

Mike Pikaartمشاهده پروفایل

استاد

• Environmental Microbiology
• Biochemistry Education
• Protein-DNA Interactions
• +۳ مورد دیگر

Dr. Mike Pikaart is a Professor of Chemistry at Hope College since 1999. He specializes in biochemistry pedagogy , environmental microbiology , and protein-DNA interactions , contributing to both undergraduate education and international water purification research. Education : PhD in Biological Chemistry (University of Michigan, 1992); BS in Chemistry (Calvin College, 1986) Research Interests span three areas: Environmental microbiology for watershed testing and filters in developing countries; biochemistry pedagogy via the BASIL consortium to determine protein functions in teaching labs; and protein-DNA interactions in gene regulation, particularly GATA proteins and beta-globin insulators. Grants include five years of continuous NSF-IUSE funding (2015–2020) and NIH grants (2003–2010) for GATA protein specificity. He actively participates in professional service , such as judging at ASBMB meetings, coaching Science Olympiad, and serving as a Grand Awards Judge for the Intel Science Fair. Community engagement includes leadership as President of the Pediatric Oncology Resource Team (PORT) at Helen DeVos Children’s Hospital and volunteering in Child Life programs since 2014.

Yida Anمشاهده پروفایل

مدرس

• Music Performance
• Violin
• Chamber Music
• +۳ مورد دیگر

Yida An is a Project Instructor at the Butler School of Music, University of Texas at Austin. He holds an Artist Diploma from Butler School of Music (studying with Brian Lewis), a Master of Music from Bard College Conservatory of Music (under Gil Shaham and Adele Anthony), and a Bachelor of Music from Central Conservatory of Music in Beijing (under Xie Haoming). His musical career includes roles as concertmaster of the Bard College Symphony Orchestra and solo performances with renowned conductors like Tan Dun and Leon Botstein. He has collaborated on major venues including Carnegie Hall and Lincoln Center, and organized solo recitals in New York. His performances span classical violin repertoire, chamber music, and orchestral collaborations, emphasizing both traditional and contemporary works. Education history includes Beijing Eastbank Academy of Music (2017-2018) and extensive touring with the Central Conservatory of Music Youth Symphony Orchestra. Notable collaborations include working with composer Joan Tower and participating in the Bard Music Festival. His musical contributions highlight technical mastery and artistic interpretation across diverse genres. While primarily focused on performance, his academic affiliations also involve interdisciplinary research in RNA biology and molecular mechanisms, as evidenced by publications in high-impact journals. These articles explore topics like group II intron mobility, exosome-mediated RNA sorting, and therapeutic applications of RNA sequencing technologies, showcasing a dual expertise in music and life sciences.

Emil Damgaard Jensenمشاهده پروفایل

پژوهشگر

• Synthetic Biology
• Genome Editing
• G Protein-Coupled Receptors
• +۴ مورد دیگر

Emil Damgaard Jensen is a Tenure Track Researcher at the Novo Nordisk Foundation Center for Biosustainability , Technical University of Denmark (DTU). His research focuses on synthetic biology, yeast engineering, and metabolic pathway optimization. He leads projects developing yeast-based screening platforms for human health applications, GPCR-based biosensors, and synthetic biology tools for industrial biotechnology. Research Interests: Genome editing in Saccharomyces cerevisiae, G protein-coupled receptors (GPCRs), high-throughput screening, and engineered yeast systems for drug discovery and metabolic engineering. His work contributes to UN Sustainable Development Goals related to health and sustainable biomanufacturing. Publications: Recent work includes HEEL genotyping technology, dual-species protein expression strategies, and GPCR-based metabolite screening. His articles span synthetic biology applications, metabolic engineering, and yeast-based platforms for medical and industrial use. Advising: Supervises PhD students including Thomas Rasmussen (synthetic biology/smart farming), Felix Hansson (natural products biosynthesis), and Mikkel Deichmann (immune cell communication tools). Collaborates widely in EU/industry projects. Labs/Teams: Leads the Synthetic Biology Tools for Yeast group at DTU Microbes Initiative. Engages in cross-disciplinary teams for cell factory development and biotechnological innovation.

Ahmed Badranمشاهده پروفایل

استادیار

• Synthetic Biology
• Genetic Engineering
• Antibiotic Development
• +۴ مورد دیگر

Dr. Ahmed Badran is an Assistant Professor in the Department of Chemistry at Scripps Research, with a joint appointment in the Skaggs Graduate School of Chemical and Biological Sciences. His lab focuses on engineering biomolecular machines to address global challenges such as antimicrobial resistance, sustainable biomanufacturing, and climate change. Key research areas include synthetic biology, directed evolution, and genome editing. Dr. Badran holds a Ph.D. in Chemical Biology from Harvard University (2016) and a B.S. in Biochemistry, Molecular Biophysics, and Molecular & Cellular Biology from the University of Arizona (2010). His work is supported by prestigious grants from NIH, NASA, the Air Force Office of Scientific Research, and the Breakthrough Energy Fellows program. His research integrates chemical biology, bioengineering, and synthetic biology to re-engineer cellular signaling networks. Recent work includes developing novel antibiotics via deep learning, optimizing ribosomes for enhanced protein production, and engineering enzymes for carbon fixation. Over 30 scientific awards and patents highlight his contributions to biotechnology and therapeutics. Dr. Badran’s lab collaborates widely, emphasizing interdisciplinary approaches to tackle pressing global issues. Current projects include creating artificial enzymes for sustainable manufacturing, precision medicine through rapid therapeutic development, and synthetic biology strategies to combat climate change.

Jarek Brykمشاهده پروفایل

استاد آموزشی

• Evolutionary genetics
• Functional and mechanistic basis of adaptive change
• Synthetic biology
• +۳ مورد دیگر

Jarek Bryk is a Teaching Professor at the Department of Physical and Life Sciences, School of Applied Sciences , University of Huddersfield . He is a member of the Evolutionary Genomics Research Centre and associate member of the Cellular and Molecular Models of Disease Centre . His career spans evolutionary genetics, synthetic biology, and science education. Education: MSc in Molecular Biology, University of Warsaw PhD in Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology Research interests focus on evolutionary genetics , mechanistic basis of adaptive change , and synthetic biology education . He investigates genetic mechanisms of environmental adaptation and develops teaching tools for molecular biology. Article trends show expertise in ancient DNA , genomic variants , and synthetic biology , with applications in education , oncology , and population genomics . Scientific awards : Bronze Medal, International Genetically Engineered Machines competition Advising includes mentoring undergraduate teams in synthetic biology. He has worked on EU-funded and Wellcome Trust projects, emphasizing practical education and student-driven research .

Ruth-Anne Sandaaمشاهده پروفایل

استاد

• Marine microbiology
• Viral-host interactions
• Marine ecology
• +۷ مورد دیگر

Ruth-Anne Sandaa is a Professor at the Department of Biosciences , University of Bergen, specializing in marine virology and microbial ecology. Her research focuses on viral-host interactions in marine environments, particularly in Arctic ecosystems. Studied biogeochemical impacts of marine viruses Explored cyanophage and phytoplankton virus dynamics Investigated viral genes influencing host metabolism Examined virus-host relationships in extreme marine habitats Her research bridges marine microbiology with ecological modeling, examining how viruses regulate microbial diversity and affect global carbon cycles through lysis and programmed cell death mechanisms. She has developed metagenomic methods for Arctic viral assemblage characterization. Recent publications (2021-2025) emphasize Arctic viral ecology , host-virus coevolution , and viral metabolic gene encoding . Key subfields include cyanophage adaptation, algal bloom virology, and deep-sea viral-host dynamics. Projects : Micropolar Microbial Network Organization (MINOS) Diversity and Dynamics of Marine Haptophytes (HAPTODIV) Technical Contributions : Developed semi-automated metagenomic characterization methods Advanced viral community analysis in extreme marine environments Created techniques for fluorometric DNA quantification in marine sediments

Joshua Restمشاهده پروفایل

دانشیار

• Evolutionary Genomics
• Gene Expression Evolution
• Horizontal Gene Transfer
• +۴ مورد دیگر

Joshua Rest is an Associate Professor and Chair of the Department of Ecology and Evolution at Stony Brook University, where he leads research in evolutionary genomics and computational biology. His work spans gene expression evolution, horizontal gene transfer, and viral-host genome interactions across diverse organisms including yeast, mammals, plants, protists, and viruses. Ph.D. in Ecology and Evolution, University of Michigan (2004) Postdoctoral Research, University of Chicago (2004-2008) Rest’s lab combines computational and experimental approaches to study how genomic changes drive biological diversity, with projects on climate adaptation, protist evolution, and metabolic network dynamics. Current initiatives include CRISPR-based lateral gene transfer studies in marine protists. His research spans 15+ years, focusing on evolutionary genomics, horizontal gene transfer, and stress response mechanisms in organisms ranging from yeast to plants. Key publications highlight metabolic network evolution, viral integration in protists, and experimental tools for marine protist studies. 2024 Dean’s Award for Excellence in Service by a Graduate Program Director 2021 Zuckerkandl Prize As Graduate Program Director (2016-2021) and current Chair, Rest mentors students and postdocs like Alex Gil Gomez and Ben Leyland. His lab collaborates globally on projects involving transcriptomics, phylogenetic analysis, and protist genetic tools. The Rest Lab at Stony Brook investigates evolutionary genomics through a team including postdoc Ben Leyland, grad students Alex Gil Gomez and Allyson C. Sheneman, and collaborator Jackie Collier. They focus on marine protists, climate adaptation, and network-level genomic analyses.

• Biochemistry
• Molecular Biology
• RNA Synthesis
• +۲ مورد دیگر

Purnima Mala is a Postdoctoral Research Associate in the Department of Chemistry at the University of Massachusetts Amherst, conducting advanced research at the intersection of biochemistry and molecular engineering. Her institutional affiliation places her within the university's core chemistry research infrastructure at Lederle Graduate Research Tower. Her research program centers on: RNA Biochemistry : Novel synthesis, modification, and quality assessment of RNA molecules Protein Engineering : Non-natural amino acid incorporation and tRNA modification strategies Biophysical Applications : Development of analytical approaches for RNA studies Analysis of her 2018-2025 publications reveals a clear progression from fundamental nucleic acid chemistry toward sophisticated biophysical applications. Her work demonstrates increasing specialization in T7 RNA polymerase mechanisms and genetic code expansion techniques, with growing emphasis on translational applications in synthetic biology and therapeutic development. Scientific Awards: No awards or honors were documented in the available materials. Advising and Grants: Current information does not specify graduate student mentorship activities or externally funded research grants associated with her position.

Eivind Valenمشاهده پروفایل

استاد

• Translation
• RNA biology
• Genome editing
• +۶ مورد دیگر

Eivind Valen is a Professor at the University of Oslo and holds multiple associate leadership roles at the Center for Molecular Medicine Norway (NCMM) , Center for Myeloid Blood Cancer (C-MYC) , Computational Biology Unit (CBU) , and Michael Sars Center . His research spans RNA biology, genome editing, and translation regulation. Research Focus: Investigates pervasive translation in non-coding regions, CRISPR applications, and RNA structure using nanopore sequencing. Key Tools: Developed CHOPCHOP platforms and ORFik for genome editing and translation analysis. Recent Article Trends: Emphasize ribosome profiling, poly(A) tail dynamics, and CRISPR precision. Awards: Includes ERC Consolidator Grant, EIC Pathfinder award, and KG Jebsen Center recognition. Collaborations: Engaged with institutions across Norway and Europe, including Technische Universität Dresden and EMBL nodes.