معرفی
Jeff Coller is the Bloomberg Distinguished Professor of RNA Biology and Therapeutics at Johns Hopkins University. His primary affiliation is with the Whiting School of Engineering and the Johns Hopkins School of Medicine, within the Department of Biomedical Engineering. He holds a PhD in Cellular and Molecular Biology from the University of Wisconsin and completed postdoctoral training at the Howard Hughes Medical Institute, University of Arizona. Previously, he was Director of the RNA Center at Case Western Reserve University and held the Henry Willson Payne Distinguished Professorship.
Research Focus: Coller's lab investigates mRNA stability and translation, particularly how mRNA sequence features like codon optimality influence gene expression. His work bridges fundamental biology and translational medicine, with a focus on RNA-based therapies. He co-founded Tevard Biosciences and WyveRNA Therapeutics, which focus on RNA therapeutics. His research has been cited over 6,000 times and led to several patents in RNA-based therapies.
- Education: PhD in Cellular and Molecular Biology, University of Wisconsin; Postdoc at HHMI, University of Arizona
- Labs/Teams: Coller Lab (Johns Hopkins University)
- Grants/Funding: Not explicitly detailed, but implied via patent activity and industry partnerships
Key Contributions: Demonstrated that mRNA sequence features directly influence stability and translation efficiency. Pioneered understanding of codon optimality's role in mRNA fate. Co-developed novel RNA-based therapeutics.
