معرفی
Carson Thoreen is an Associate Professor in the Department of Cellular & Molecular Physiology at Yale School of Medicine. His research focuses on the mTOR signaling pathway's role in regulating cell growth, metabolism, and mRNA translation. He holds appointments in multiple interdisciplinary centers including the Center for RNA Science and Medicine and the Diabetes Research Center.
Education: PhD from MIT (2008) and ScB in Biology from Brown University (2000).
Research Interests: Mechanisms of mTOR-regulated translation, mRNA stability, and metabolic signaling pathways. His lab investigates how nutrient availability and mTOR activity control protein synthesis and cellular growth, with implications for cancer and aging.
Key Publications: Includes seminal work on mTOR's role in TOP motif mRNA regulation, LARP1-mediated translation control, and the development of novel mTOR inhibitors. Recent studies explore mRNA 5' terminal sequences' impact on expression dynamics.
Scientific Contributions: Pioneered methods like Roadblock-qPCR for mRNA stability analysis and contributed to understanding post-transcriptional control of ATF4.
Lab: Thoreen Lab focuses on integrating biochemical, genetic, and systems biology approaches to uncover translational regulatory networks.
