معرفی
Wendy V. Gilbert, PhD, is the Maxine F. Singer '57 Professor of Molecular Biophysics and Biochemistry at Yale School of Medicine. Her research focuses on RNA regulatory elements controlling mRNA biogenesis, translation, and decay, with recent emphasis on RNA base modifications. She leads the Gilbert Lab, which has made landmark contributions including identifying mRNA modification defects' effects on ribosome function, discovering RACK1's role in mRNA translation efficiency, and pioneering methods to study RNA modifications.
Education:
- AB in Molecular Biology, Princeton University
- PhD in Biochemistry, University of California, San Francisco (UCSF)
- Postdoc at UC Berkeley under Jennifer Doudna
Research Interests: Her work spans RNA structure-function relationships, translational control mechanisms, and the role of RNA modifications like pseudouridylation in health and disease. The lab employs advanced sequencing techniques and bioinformatics to map modifications and study their biological impacts.
Publications: Over 20 peer-reviewed articles since 2001, including high-impact studies in Nature, Science, and Molecular Cell. Recent work emphasizes translational regulation, mRNA modification detection challenges, and therapeutic applications of modified mRNAs.
Awards:
- RNA Society Early Career Award (2017)
- RNA Society Inclusive Leadership Award (2023)
- Yale Poorvu Prize for Academic Innovation (2020)
Lab & Collaborations: Affiliated with Yale Cancer Center, Genomics/Epigenetics programs, and the Center for RNA Science and Medicine. Collaborates widely, including with Carson Thoreen (Yale) and international teams in RNA research.
