Jan Erzberger

Jan Erzberger, Ph.D., joined the faculty of UT Southwestern Medical Center in 2015, where he leads the Erzberger Lab in studying ribosome biogenesis. His work focuses on ATPases and GTPases in coordinating ribosomal RNA processing and integrating these processes with cell cycle control.

• Education:
  • Biological Chemistry, Harvard University
  • Molecular and Cell Biology, University of California, Berkeley

Dr. Erzberger’s research combines X-ray crystallography, cryo-electron microscopy, mass spectrometry, and computational modeling to unravel the molecular dynamics of protein-RNA complexes. His lab investigates how ATPases and methyltransferases guide RNA modifications critical for 60S ribosomal subunit biogenesis.

The Erzberger Lab has published studies on bacterial DNA replication, eukaryotic translation initiation, and ribosome assembly mechanisms. Their integrative structural approaches provide insights into the conserved core of histone deposition proteins and the role of Gle1 in mRNA export.