Nagesh Peddada

Nagesh Peddada is an Assistant Professor at the University of Texas Southwestern Medical Center (UT Southwestern), affiliated with the Center for Genetics of Host Defense under Nobel Laureate Dr. Bruce Beutler. He holds a Ph.D. in Protein Science and Engineering from CSIR-Institute of Microbial Technology, India, and completed postdoctoral training in Jan Erzberger's laboratory at UT Southwestern, focusing on eukaryotic ribosome biogenesis. His research integrates structural biology techniques like cryo-EM and mass spectrometry to study macromolecular complex assembly, with emphasis on proteasome-activating factors, GTPases, and RNA/DNA binding proteins identified via ENU mutagenesis.

Education:

• Bachelor's in Biotechnology, Madurai Kamaraj University
• Ph.D., Protein Science and Engineering, CSIR-Institute of Microbial Technology
• Postdoctoral Research: UT Southwestern Medical Center (Jan Erzberger Lab)

Research Interests:
His work spans structural biology, ribosome assembly mechanisms, proteasome function, and actin cytoskeleton dynamics. Key projects include studying DEAD-box ATPases' roles in ribosomal RNA remodeling and elucidating midnolin's role in proteasome regulation and B-cell malignancies.

Publications Trends:
Peddada's work emphasizes structural insights into actin dynamics (e.g., gelsolin's roles in F-actin severing) and ribosome biogenesis. Recent studies reveal novel mechanisms in midnolin-proteasome pathways and ribosomal RNA processing, with implications for cancer biology and genetic disorders.

Lab & Collaborations:
Based in the Beutler Lab, his team employs integrative structural biology approaches to uncover molecular mechanisms underlying cellular processes. Collaborations focus on translating structural findings into functional insights for disease contexts like leukemia and HIV pathogenesis.