معرفی
Dr. Carl C. Correll serves as Associate Professor in the Department of Biochemistry and Molecular Biology at Rosalind Franklin University's Chicago Medical School, with dual appointments in the School of Graduate and Postdoctoral Studies and the Center for Proteomics and Molecular Therapeutics.
His research centers on ribosome biogenesis mechanisms, specifically the dynamic RNA-protein interactions governing pre-ribosomal assembly. The lab investigates how the DEAH helicase Dhr1 dislodges U3 snoRNA from pre-ribosomes—a process critical for ribosome maturation and emerging as a cancer therapeutic target—and how regulators like Utp14 control Dhr1 activity. These studies combine biochemical, genetic, and structural approaches to unravel fundamental cellular processes.
Dr. Correll's publication record spans two decades with consistent output in high-impact journals including PLOS Biology, Molecular and Cellular Biology, and Nature Structural & Molecular Biology. His work shows a clear trajectory from structural RNA biochemistry (early 2000s) toward mechanistic dissection of ribosome assembly factors, with increasing focus on cancer-relevant pathways since 2015.
Scientific recognition includes:
- American Cancer Society Postdoctoral Fellowship
Dr. Correll mentors PhD students and postdocs, with alumni securing positions at Scripps Florida, Winthrop University, and industry roles. Current projects examine Dhr1 regulation by Utp14 and Imp3/Imp4 control by Mpp10, supported through institutional resources and collaborations with Dr. Johnson's lab at UT Austin.
The lab operates within Rosalind Franklin's Center for Proteomics and Molecular Therapeutics, providing access to advanced biochemical and molecular facilities for studying RNA-protein dynamics with direct implications for ribosomopathy-related diseases.
