Jun Xie

Jun Xie is an Associate Professor at the UMass Chan Medical School and holds multiple positions in departments including the Gene Therapy Center, Genetic and Cellular Medicine, and Microbiology. His research focuses on adeno-associated virus (AAV) vector technology and AAV-mediated miRNA therapeutics, with applications in gene therapy for diseases like osteoporosis, spinal muscular atrophy, and fibrodysplasia ossificans progressiva.

• BS in Plant Genetics & Breeding from Huazhong Agricultural University, China
• MS in Molecular Biology & Biochemistry from Huazhong Agricultural University, China
• PhD in Genetics from Sun Yat-sen University of Medical Sciences, China

Xie's recent work explores CRISPR/Cas9 genome editing delivered via AAV vectors, including studies on bone disease treatment (osteogenesis imperfecta, alveolar bone loss), neurological disorder therapies (spinal muscular atrophy), and immune-evasive AAV designs. His publications emphasize vector engineering to improve safety, targeting specificity, and therapeutic efficacy.

Key trends in his 15 most recent articles include AAV serotype optimization (e.g., AAV5, AAV9), adenine base editing with engineered Cas9 variants, and miRNA-based interventions for metabolic and inflammatory conditions. His work spans preclinical rhesus monkey models and translational gene therapy applications.