معرفی
Associate Professor Grant Logan is a Senior Lecturer at the University of Sydney and a Research Scientist at the Children’s Medical Research Institute. He also serves as an Honorary Hospital Scientist at the Children’s Hospital at Westmead, where he develops serological tools to assess gene therapy eligibility.
- University of Sydney
- Children’s Medical Research Institute
- Children’s Hospital at Westmead
Logan’s research focuses on the immunobiology of gene therapies using adeno-associated virus (AAV) vectors. His work explores host-vector interactions, pre-existing immunity, and strategies to enhance gene therapy efficacy for autoimmune and rheumatological disorders. He has contributed to understanding AAV vector tolerogenicity and immune modulation.
Recent publications highlight his work on AAV vector engineering for liver-specific expression, DNaseI delivery in lupus models, and anti-AAV antibody characterization in spinal muscular atrophy patients.
- Honorary Hospital Scientist at Children’s Hospital at Westmead
- Member, Gene Therapy Technical Advisory Committee to Australian Office of the Gene Technology Regulator
- Collaborations with biotech industry and multiple patents
Key grants include:
- 2024: NHMRC Ideas Grant for AAV bioengineering to escape pre-existing immunity
- 2022: NHMRC Ideas Grant for pharmaco-genetic autoimmune kidney disease treatment
- 2020: NHMRC Ideas Grant for anti-capsid immunity in SMA gene therapy
