جست‌وجوی استاد و پژوهشگر

Xue Baoمشاهده پروفایل

پژوهشگر

• Molecular Biology
• Biochemistry
• Lipid Metabolism
• +۵ مورد دیگر

Dr. Xue Bao is a Researcher and Teacher at the Department of Biology, Faculty of Science, Utrecht University , specializing in Genome Biology and Epigenetics. She is based at the Hugo R. Kruyt Building in Utrecht and holds a PhD from Utrecht University obtained in 2018. Research Interests: Her research spans molecular biology, biochemistry, and cell biology, with a strong focus on lipid metabolism, membrane biology, and epigenetics . Early work centered on lipid acyl chain remodeling and phosphatidylcholine deficiency in yeast, while recent publications extend into chromatin regulation and neuronal differentiation. Her expertise bridges yeast genetics and mammalian epigenetic mechanisms. Publication Trends: Her work over the past decade shows a clear trajectory from fundamental yeast lipid biology to complex epigenetic regulation in higher systems. She frequently publishes in high-impact journals such as Nature Genetics , EMBO Journal , and iScience , often collaborating with leading groups in epigenetics. Her research combines biochemical, genetic, and molecular approaches to understand membrane and chromatin dynamics. Roles and Affiliations: Position: Researcher and Teacher Institution: Utrecht University Faculty: Faculty of Science Department: Biology Research Group: Genome Biology and Epigenetics ORCID: 0000-0002-5129-0728 Advising and Grants: While no specific students or grant funding are mentioned in the provided texts, her role as a teacher and active researcher suggests involvement in mentoring and research supervision. Her consistent publication record indicates sustained research activity, likely supported by institutional or external funding. Laboratories and Teams: Dr. Bao is part of the Genome Biology and Epigenetics research group within the Biodynamics and Biocomplexity division at Utrecht University. She collaborates extensively with researchers such as Prof. Tuncay Baubec and Prof. Toon de Kroon, indicating integration into collaborative research teams focused on epigenetics and membrane biology, respectively.

Katie Kathreinمشاهده پروفایل

استادیار

• Stem Cell Biology
• Developmental Biology
• Hematopoiesis
• +۴ مورد دیگر

Katie Kathrein is an Assistant Professor in the Department of Biological Sciences at the University of South Carolina's College of Arts and Sciences. Her research focuses on chromatin modifying factors in hematopoietic stem cells (HSCs) using zebrafish as a model organism. Research Interests The Kathrein Lab investigates how chromatin structure regulates HSC gene expression during development and differentiation. Key areas include: Epigenetic mechanisms in hematopoiesis Chromatin remodeling complexes 3D DNA organization Transcriptional regulation by histone modifications Zebrafish developmental models Therapeutic applications in stem cell transplants and cancer chemotherapy Publications Overview Dr. Kathrein's work spans developmental biology and epigenetics, with a focus on hematopoietic regulation through chromatin structure. Her publications highlight collaborations with prominent researchers in stem cell biology and developmental genetics, primarily using zebrafish models to explore fundamental biological processes.

• DNA Repair
• Epigenetics
• DNA Methylation
• +۴ مورد دیگر

Dr. Alexander C. Drohat is a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine. His research focuses on DNA repair mechanisms and epigenetic regulation through DNA methylation, with a particular emphasis on thymine DNA glycosylase (TDG) and SUMO modification pathways. Utilizing biochemical, biophysical, and structural approaches—including NMR spectroscopy and crystallography—his lab explores how TDG maintains genomic integrity by repairing oxidized and deaminated bases, while also investigating its role in active DNA demethylation via TET enzymes. Notably, his work reveals how SUMO conjugation dramatically impairs TDG activity, potentially enabling it to function as a transient reader of modified cytosines. His lab has characterized TDG's interactions with substrates like G·T mismatches, 5-formylcytosine, and 5-carboxylcytosine, uncovering critical residues and mechanisms for specificity and catalysis. Recent studies highlight TDG's search strategies involving nucleosome interactions and its regulation by sumoylation. 2025 : Characterized 7,8-dihydro-8-oxoadenine repair 2024 : Investigated TDG sumoylation effects on DNA binding 2023 : Developed 19F NMR methods for nucleotide flipping 2022 : Linked TDG activity to genomic methylation patterns 2019 : Defined TDG's role in 5-carboxylcytosine excision Dr. Drohat has received prestigious accolades including AAAS Fellowship (2022) and an NIGMS MIRA Award (R35GM136225, 2020-2025) . His work is supported by continuous NIH funding since 2005.

Nathaniel Hathawayمشاهده پروفایل

استادیار

• Epigenetics
• Chemical Biology
• Gene Expression
• +۳ مورد دیگر

Nathaniel Hathaway , PhD, is an Assistant Professor at the Eshelman School of Pharmacy , UNC-Chapel Hill, and a member of the UNC Lineberger Comprehensive Cancer Center. His research bridges chemical biology and epigenetics to unravel molecular mechanisms governing gene expression , with a focus on chromatin dynamics and heterochromatin formation . Education: Undergraduate degree magna cum laude (2001), Michelson-Morley Research Competition winner (2000). Hathaway's lab pioneers chemical epigenetic modifiers (CEMs) that harness endogenous chromatin machinery via dCas9 targeting to regulate gene expression. His work also involves high-throughput drug discovery for epigenetic inhibitors in cancer and other diseases. Recent publications highlight CRISPR-CEM fusion systems , PROTAC-based PRC2 degradation , and computational models of heterochromatin . Key awards: CBMC Teaching Recognition (2016, 2017) IBM Junior Faculty Development Award (2017) AACP New Investigator Award (2016) Hathaway's research integrates protein bioengineering , synthetic chemistry , and mammalian models to address fundamental questions in epigenetic memory and develop translational therapies for cancer.

Müller Christophمشاهده پروفایل

استاد پژوهشی

• Protein crystallography
• RNA polymerase transcription
• Integrated structural biology
• +۴ مورد دیگر

Christoph Müller is a Research Professor leading the Structural and Computational Biology Unit at EMBL Heidelberg since 2007. He previously served as Deputy Head at EMBL Grenoble (2000-2007) and has been a Senior Scientist at EMBL since 2000. His research focuses on protein crystallography, RNA polymerase mechanisms, and integrated structural biology. Key contributions include studies on RNA polymerases I/III transcription, chromatin modifying complexes, and transcription factor interactions. Education: PhD in X-ray Crystallography & Biochemistry (1991), University of Freiburg MSc in Chemistry & Biochemistry (1986), University of Freiburg Postdoctoral training at Harvard University (1992-1995) and University of Freiburg (1991) His work bridges structural biology with functional mechanisms, employing cutting-edge techniques like cryo-EM and X-ray crystallography. Major achievements include solving the structure of the 14-subunit RNA polymerase I and elucidating promoter-opening mechanisms in RNA polymerase III. Awards: ERC Advanced Investigator Grant (2013) EMBO Membership (2005) Steinhofer Award (2003) His research group investigates transcriptional regulation at molecular and structural levels, with recent work exploring BET protein interactions and tRNA modification pathways. Collaborations span structural biology, epigenetics, and developmental biology.

Emily Wileyمشاهده پروفایل

استاد

• Chromatin Structure
• Gene Expression Regulation
• Epigenetics
• +۵ مورد دیگر

Emily Wiley is a Professor of Biology at the Keck Science Department, part of the Claremont Colleges consortium. Her research focuses on histone modifications, chromatin structure, and gene expression regulation in Tetrahymena thermophila , a model organism for studying nuclear differentiation. University: Claremont Colleges Department: Biology Email: ewiley@kecksci.claremont.edu Wiley's work explores the role of histone deacetylases (HDACs) in chromatin dynamics and heterochromatin assembly. Her lab investigates how these enzymes influence nuclear integrity, DNA maintenance, and cellular processes like transcription and replication. Notable research includes studies on the class I HDAC Thd1p and its impact on chromatin condensation and gene regulation. She has secured significant funding, including an NSF CAREER Award (2006-13), NSF Sub-Award (2012-17) for Tetrahymena genomics, and an NSF IUSE Award (2014-18) to integrate teaching with research via the Ciliate Genomics Consortium model. NSF CAREER Award: 'Investigating Chromatin Assembly Pathways Through Histone Deacetylases' NSF Sub-Award: 'Genomics of Tetrahymena' NSF IUSE Award: 'The Ciliate Genomics Consortium Model for Sustainable Teaching-Research Integration' Her students engage in projects such as GFP-tagging histone deacetylases, engineering gene knockouts, and identifying chromatin-modifying protein complexes. Wiley also contributes to educational resources, including laboratory manuals like Current Protocols: Essential Laboratory Techniques .

Anne Brunetمشاهده پروفایل

استاد

• Aging
• Longevity
• Neural Stem Cells
• +۷ مورد دیگر

Anne Brunet holds the Michele and Timothy Barakett Endowed Professorship in the Department of Genetics at Stanford University School of Medicine. She is a leading researcher in the field of aging and longevity with extensive affiliations across multiple Stanford institutes including the Bio-X Program, Cardiovascular Institute, Wu Tsai Human Performance Alliance, Stanford Cancer Institute, and Wu Tsai Neurosciences Institute. Dr. Brunet's research focuses on the molecular mechanisms of aging and longevity, with special emphasis on the nervous system. Her lab investigates pathways involved in delaying aging in response to external stimuli such as nutrient availability and mates, mechanisms influencing the rejuvenation of old stem cells, and has pioneered the use of the naturally short-lived African killifish as a model to explore aging regulation and age-related diseases. She has a long-standing interest in the insulin-FOXO transcription factor pathway, which regulates lifespan from worms to humans, and studies how longevity genes maintain adult neural stem cells and cognitive function during aging. Analysis of her recent publications (2023-2025) reveals a strong focus on spatial transcriptomics of brain aging, CRISPR-Cas9 screening for aging regulators in neural stem cells, protein aggregation in aging vertebrates, and the development of the African killifish as a model organism. Her work integrates cutting-edge technologies including single-cell and spatial transcriptomics, high-throughput genetic screening, and multi-omics approaches to study aging across tissues. Scientific Awards: Transformative Research Award, NIH Directors' Fund (2018) Pioneer Award, NIH Director's Fund (2012) Senior Scholar Award, Ellison Medical Foundation (2009) Alfred P. Sloan Fellow, Sloan Foundation (2006) Multiple awards for mentoring and aging research Dr. Brunet actively mentors numerous graduate students and postdocs, serving as Doctoral Dissertation Advisor, Co-Advisor, and Reader for over 15 students, and sponsoring 7 postdoctoral fellows. She teaches courses including Current Issues in Aging and multiple directed reading/research courses in Genetics, Neurosciences, and Stem Cell Biology. Her lab, the Brunet Lab, is part of the Paul F. Glenn Laboratories for the Biology of Aging and focuses on understanding the genetic mechanisms of aging through multiple complementary approaches including mammalian models, C. elegans, and the African killifish.

Savas Tayمشاهده پروفایل

استاد

• Immune Signaling
• Single-Cell Analysis
• Microfluidics
• +۵ مورد دیگر

Savas Tay is a Professor of Molecular Engineering and Director of the Biological and Immuno Engineering Research Theme at the University of Chicago Pritzker School of Molecular Engineering. His research focuses on immune signaling, single-cell analysis, microfluidics, infectious diseases, and microbiome dynamics. He directs the Tay Lab and is affiliated with the Institute for Genomics and Systems Biology. He holds a PhD in Optical Sciences from the University of Arizona and conducted postdoctoral research at Stanford University. His research integrates experimental and computational approaches to study cellular communication networks, developing innovative technologies like microfluidic devices and proximity sequencing for high-throughput biological analysis. Key projects include studying herpesvirus replication mechanisms, SARS-CoV-2 pathogenesis, and drug repurposing strategies for viral infections. Education: PhD in Optical Sciences, University of Arizona Postdoctoral Research, Stanford University Bioengineering Prof. Tay has secured major grants including the ERC Starting Grant (2013) and Paul G. Allen Distinguished Investigator Award (2019). His work has been featured in Nature , Science , Cell , and media outlets like BBC and National Geographic. Awards: ERC Starting Grant (2013) Paul G. Allen Distinguished Investigator Award (2019) Labs/Teams: Tay Lab at UChicago Pritzker School of Molecular Engineering His recent work emphasizes high-throughput systems for analyzing cell signaling dynamics, including microfluidic platforms for studying metastasis and viral replication. Collaborations span engineering, immunology, and computational biology to address complex biological questions.

Jhih-Rong Linمشاهده پروفایل

عضو هیئت علمی

• Genetics
• Genomics
• Aging and Longevity
• +۳ مورد دیگر

Jhih-Rong Lin is a Research Assistant Professor in the Department of Genetics at Albert Einstein College of Medicine. His research focuses on understanding the genetic and genomic mechanisms underlying complex human diseases, particularly neurodegenerative disorders, longevity, and developmental syndromes. He employs computational and systems biology approaches to analyze genomic data, identify disease risk genes, and model genetic pathways. Key research themes include: Genetic variants associated with aging and neurodegeneration (e.g., Alzheimer’s disease, schizophrenia) Post-GWAS analysis for disease gene prioritization (e.g., using tools like PGA) Evolutionary genomics of longevity (e.g., studies on beaver genomes) Epigenetic regulation in cancer progression and development Lin’s work bridges computational methods with experimental validation, contributing to drug discovery for aging-related conditions and improving understanding of genetic modifiers in syndromic disorders. His recent publications highlight discoveries in rare variant analysis, polygenic risk prediction, and systems-level aging mechanisms.

James Broachمشاهده پروفایل

استاد

• Molecular Biology
• Genetics
• Precision Medicine
• +۷ مورد دیگر

James Broach is a Distinguished Professor and Interim Chair of the Department of Molecular and Precision Medicine at Penn State College of Medicine. He also serves as Professor in the Department of Otolaryngology - Head and Neck Surgery, Director of the Institute for Personalized Medicine, and Member of the Penn State Cancer Institute's Next-Generation Therapies program. His leadership spans multiple departments and research initiatives focused on genomic medicine and personalized healthcare approaches. Dr. Broach's research interests center on molecular biology and genetics, with particular expertise in yeast Saccharomyces as a model system for studying cellular processes. His laboratory has extensively investigated cell signaling pathways including Ras/protein kinase A and Target of Rapamycin Complex, examining how cells perceive nutritional states and respond metabolically and transcriptionally. More recently, his work has expanded to cellular stress responses using single-cell imaging and genomic sequencing techniques, revealing how genetically identical cells develop heterogeneous responses to environmental stresses. His research has significant implications for understanding population-level survival strategies in uncertain conditions. Through the Institute for Personalized Medicine, Dr. Broach has applied genomic tools to disease onset and treatment across multiple conditions including various cancers, ALS, multiple sclerosis, inflammatory bowel disease, epilepsy, and osteoporosis. His recent publications demonstrate a strong focus on precision medicine applications, cancer biology, and genomic data frameworks that integrate clinical information with genetic profiling. Among his notable scientific achievements are two Career Citation Milestone Awards: the M (1000) Club award in 2017 and the D (500) Club award in 2020, recognizing his substantial research impact. His h-index of 72 with over 18,259 citations reflects significant scholarly influence in his fields. Dr. Broach has secured substantial research funding through multiple grants from prestigious organizations including the National Institutes of Health, National Science Foundation, and National Center for Research Resources. His current projects include the Penn State Biomedical Big Data to Knowledge (B2D2K) Training Program and continued research on Ras and TOR Signaling in Yeast. He collaborates extensively with clinicians at the Milton S. Hershey Medical Center to identify patient cohorts with distinctive disease presentations or treatment responses. The Institute for Personalized Medicine, which Dr. Broach directs, comprises a comprehensive infrastructure including a biorepository for patient samples, a genomics core for advanced sequencing, and a bioinformatics core for correlating genomic data with clinical outcomes. This integrated approach enables groundbreaking research in precision medicine applications across multiple disease areas.

Paul Watersمشاهده پروفایل

دانشیار

• Epigenetics
• Molecular Biology
• Sex Chromosome Evolution
• +۴ مورد دیگر

Associate Professor Paul Waters is affiliated with the University of New South Wales in the School of Biotechnology and Biomolecular Sciences . His research program focuses on epigenetic regulation of transcription in vertebrates , particularly sex chromosome evolution and dosage compensation mechanisms across diverse species including marsupials , monotremes , and reptiles . Current projects investigate X chromosome inactivation in wallabies and Tasmanian devils, thermolabile sex determination in the Australian central bearded dragon, and chromatin regulation during hibernation in reptiles. Active PhD/MSc/Honours/3rd-year projects available in Epigenetics and Molecular Biology Teaching Genetics (BABS2204/2264) and other molecular genetics courses Research Trends : Analysis of 15 recent articles reveals sustained focus on sex chromosome biology (X/Y evolution, dosage compensation), epigenetic silencing (DNA methylation, chromatin modifiers), and comparative genomics (marsupial models, platypus, reptiles). Additional work on long non-coding RNAs (e.g., Xist/RSX), meiotic chromosome dynamics , and transposable element evolution . Scientific Awards : NHMRC Ideas Grant APP1182667 (2020-2023) ARC Discovery Project DP180100931 (2018-2020) ARC Discovery Project DP170101147 (2017-2020) Australian Research Fellowship DP0987091 (2009-2014) ARC Discovery Project DP0987091 (2009-2014) Advising & Grants : Supervises PhD/MSc/Honours/undergraduate researchers in epigenetics and molecular biology. Holds multiple ARC/NHMRC grants totaling over $2.5 million , including work on drug-seeking silencing (2020), meiotic sex chromosome evolution (2015), and ancestral genome reconstruction (2008). Collaborations span University of Adelaide , Monash University , ANU , and University of Stellenbosch . Labs & Teams : Leads a research group studying sex chromosome evolution using genomic assemblies , fluorescence in-situ hybridization , and 3D chromatin analysis . Collaborates with Indigenous conservation groups , genomic sequencing teams , and international cytogeneticists (e.g., Ruiz-Herrera, Marshall Graves, Georges). Lab focuses on reptilian hibernation genomics , transmissible cancer epigenetics , and meiotic dynamics in basal mammals .

• Computational Structural Biology
• Statistical Machine Learning
• DNA Shape Prediction
• +۴ مورد دیگر

Remo Rohs is a tenured Professor of Quantitative and Computational Biology, Chemistry, Physics and Astronomy, Computer Science, and Biomedical Engineering at the University of Southern California Dornsife College. He leads the Rohs Lab, focusing on integrating genomics and structural biology to uncover molecular mechanisms in gene regulation. Chair, Department of Quantitative and Computational Biology (2021–2024) Section Head, Quantitative and Computational Biology (2018–2020) Full Professor with Tenure at USC (2016–present) Research Interests center on: Computational structural biology DNA shape prediction Protein-DNA recognition mechanisms Epigenetic effects on binding specificity RNA structure modeling High-throughput genomic analysis His work combines artificial intelligence , molecular simulations , and experimental validation to study transcription factors and chromatin structure. Recent publications highlight deep learning methods for DNA/RNA structure prediction and database development for molecular interactions. Scientific Awards include: Sloan Research Fellowship (2013–2017) Multiple RECOMB/ISCB Top-Paper Awards (2012–2017) American Chemical Society OpenEye Outstanding Junior Faculty Award (2015–2016) USC Mentoring Award (2015–2016) He has supervised 13 PhD graduates and published 92+ peer-reviewed papers . His lab develops tools like DNAproDB and TFBSshape for structural analysis of nucleic acid complexes.

• Epigenetics
• Cancer Biology
• Chromatin Modifications
• +۵ مورد دیگر

Dr. Yali Dou is a Professor of Medicine and Cancer Biology at the University of Southern California (USC) , holding the Marion and Harry Keiper Chair in Cancer Research . She co-directs the Ph.D. Program in Molecular Medicine and the USC Norris Brown Center for Cancer Drug Development , focusing on epigenetic mechanisms in cancer and development. Research Interests Epigenetic regulation of cell fate Chromatin modifications and gene networks MLL/KMT2 methyltransferases in leukemia Metabolic-genomic interplay Her work explores how histone methyltransferases like MLL1/3 contribute to oncogenic transformation and developmental disorders, with recent studies on nucleoprotein organization, metabolic heterogeneity, and kidney organoid modeling. Key Scientific Awards AAAS Fellow (2025) Leukemia & Lymphoma Society Scholar Award (2012) Stand Up to Cancer IRG Award (2011) AACR Gertrude B. Elion Award (2010) Dean’s Award in Basic Science, University of Michigan (2014) Dr. Dou’s lab investigates chromatin-based therapies for cancer and regenerative medicine, publishing extensively on MLL complexes, MOF acetyltransferase, and epigenetic-metabolic crosstalk.

Karim-Jean Armacheمشاهده پروفایل

استاد

• Epigenetics
• Gene Regulation
• Transcription
• +۳ مورد دیگر

Karim-Jean Armache is the Laura and Isaac Perlmutter Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, part of NYU Langone Health. His research focuses on chromatin-modifying complexes like Polycomb Group (PcG), Trithorax Group (TrxG), and DNA methylation machinery, investigating their roles in gene regulation and their links to cancer and developmental disorders. Education: PhD from Ludwig Maximilian University Munich. His work spans epigenetics, chromatin structure, and cancer biology. Recent publications highlight mechanisms of histone modification, Polycomb complex activities, and cancer-associated epigenetic dysregulation. Received the Packard Foundation Fellow award. Led studies on chromatin dynamics and epigenetic regulation in disease contexts. Lab: Armache Lab focuses on molecular mechanisms of chromatin regulation, with ongoing projects on Polycomb complexes and cancer epigenetics. Collaborations include structural biology and biochemical approaches to probe chromatin states.

Virginia M. Shapiroمشاهده پروفایل

استاد

• Immunology
• T Cell Development
• Hematopoiesis
• +۹ مورد دیگر

Virginia M. Shapiro, Ph.D., is a Professor in the Department of Immunology at Mayo Clinic and a key leader in the Mayo Clinic Graduate School of Biomedical Sciences, where she serves as Associate Dean for Faculty Affairs. She leads the David F. and Margaret T. Grohne Cancer Immunology and Immunotherapeutics Research Program within the Mayo Clinic Comprehensive Cancer Center. Her research is centered on the molecular mechanisms governing T cell development, activation, and immune regulation, with significant implications for autoimmune diseases and cancer immunotherapy. Dr. Shapiro’s research focuses on transcriptional and epigenetic regulation in lymphocyte development, particularly how chromatin-modifying enzymes and transcriptional repressors control T cell maturation. She also investigates the role of sialic acid modifications in immune signaling through Siglec receptors and studies early hematopoietic processes. Her lab explores how dysregulation in these pathways contributes to diseases such as arthritis, diabetes, and cancer. Recent studies highlight her work on B cell immunity, mitochondrial fitness, and immune modulation in tumor environments. Her research is supported by multiple NIH grants, including ongoing projects on autoimmune diabetes, T cell anergy, and B cell development. Dr. Shapiro leads a major NIH-funded Training Program in Immunology, emphasizing her role in mentoring the next generation of scientists. Her publication record includes high-impact articles in journals such as Nature Communications , Immunity , Science , and eLife , demonstrating sustained contributions to immunology and molecular medicine. Dr. Shapiro has received notable honors, including Teacher of the Year (2012) and the Dean’s Recognition Award (2019) from the Mayo Clinic Graduate School. She has held national leadership roles, such as Standing Member of the NIH Molecular and Cellular Hematology Study Section and Chair of the American Association of Immunologists’ Nominating Committee and Committee on the Status of Women. She earned her Ph.D. in Molecular and Cell Biology from the University of California, Berkeley, completed a postdoctoral fellowship at the University of California, San Francisco, and holds an AB in Biochemistry, magna cum laude, from Harvard University. She is actively involved in academic service, grant review, and scientific conferences, and her work continues to advance understanding of immune system development and regulation.