معرفی
Anne Brunet holds the Michele and Timothy Barakett Endowed Professorship in the Department of Genetics at Stanford University School of Medicine. She is a leading researcher in the field of aging and longevity with extensive affiliations across multiple Stanford institutes including the Bio-X Program, Cardiovascular Institute, Wu Tsai Human Performance Alliance, Stanford Cancer Institute, and Wu Tsai Neurosciences Institute.
Dr. Brunet's research focuses on the molecular mechanisms of aging and longevity, with special emphasis on the nervous system. Her lab investigates pathways involved in delaying aging in response to external stimuli such as nutrient availability and mates, mechanisms influencing the rejuvenation of old stem cells, and has pioneered the use of the naturally short-lived African killifish as a model to explore aging regulation and age-related diseases. She has a long-standing interest in the insulin-FOXO transcription factor pathway, which regulates lifespan from worms to humans, and studies how longevity genes maintain adult neural stem cells and cognitive function during aging.
Analysis of her recent publications (2023-2025) reveals a strong focus on spatial transcriptomics of brain aging, CRISPR-Cas9 screening for aging regulators in neural stem cells, protein aggregation in aging vertebrates, and the development of the African killifish as a model organism. Her work integrates cutting-edge technologies including single-cell and spatial transcriptomics, high-throughput genetic screening, and multi-omics approaches to study aging across tissues.
Scientific Awards:
- Transformative Research Award, NIH Directors' Fund (2018)
- Pioneer Award, NIH Director's Fund (2012)
- Senior Scholar Award, Ellison Medical Foundation (2009)
- Alfred P. Sloan Fellow, Sloan Foundation (2006)
- Multiple awards for mentoring and aging research
Dr. Brunet actively mentors numerous graduate students and postdocs, serving as Doctoral Dissertation Advisor, Co-Advisor, and Reader for over 15 students, and sponsoring 7 postdoctoral fellows. She teaches courses including Current Issues in Aging and multiple directed reading/research courses in Genetics, Neurosciences, and Stem Cell Biology. Her lab, the Brunet Lab, is part of the Paul F. Glenn Laboratories for the Biology of Aging and focuses on understanding the genetic mechanisms of aging through multiple complementary approaches including mammalian models, C. elegans, and the African killifish.
