معرفی
Emily Wiley is a Professor of Biology at the Keck Science Department, part of the Claremont Colleges consortium. Her research focuses on histone modifications, chromatin structure, and gene expression regulation in Tetrahymena thermophila, a model organism for studying nuclear differentiation.
- University: Claremont Colleges
- Department: Biology
- Email: ewiley@kecksci.claremont.edu
Wiley's work explores the role of histone deacetylases (HDACs) in chromatin dynamics and heterochromatin assembly. Her lab investigates how these enzymes influence nuclear integrity, DNA maintenance, and cellular processes like transcription and replication. Notable research includes studies on the class I HDAC Thd1p and its impact on chromatin condensation and gene regulation.
She has secured significant funding, including an NSF CAREER Award (2006-13), NSF Sub-Award (2012-17) for Tetrahymena genomics, and an NSF IUSE Award (2014-18) to integrate teaching with research via the Ciliate Genomics Consortium model.
- NSF CAREER Award: 'Investigating Chromatin Assembly Pathways Through Histone Deacetylases'
- NSF Sub-Award: 'Genomics of Tetrahymena'
- NSF IUSE Award: 'The Ciliate Genomics Consortium Model for Sustainable Teaching-Research Integration'
Her students engage in projects such as GFP-tagging histone deacetylases, engineering gene knockouts, and identifying chromatin-modifying protein complexes. Wiley also contributes to educational resources, including laboratory manuals like Current Protocols: Essential Laboratory Techniques.
