معرفی
Professor John Schwabe is a Professor of Structural Biology at the University of Leicester's Department of Molecular and Cell Biology. His research focuses on understanding the molecular mechanisms of nuclear enzymes involved in gene regulation, particularly through the assembly of large molecular machines. His work has advanced knowledge of how these complexes interact with other proteins and are affected by diseases. He leads a group using cryo-electron microscopy to visualize molecular structures at atomic resolution, supported by the Regional Cryo-Electron Microscopy facility.
His research interests include chromatin biology, histone deacetylase (HDAC) complexes, epigenetic regulation, and the structural basis of enzyme function. His studies integrate biochemical, structural, and cellular approaches to dissect the roles of these complexes in health and disease. Recent work explores the development of targeted proteolysis agents (PROTACs) to degrade specific HDACs for therapeutic applications.
Publications highlight his contributions to understanding HDAC interactions, oncogenic Ras signaling, and cholesterol transport mechanisms. His findings bridge basic research and translational medicine, particularly in cancer and metabolic disorders. Awards and grants for his work are not explicitly listed in the provided text. His laboratory collaborates on cutting-edge structural biology projects, leveraging advanced imaging and biochemical techniques to unravel complex biological systems.
