جست‌وجوی استاد و پژوهشگر

Craig A. Glastonburyمشاهده پروفایل

پژوهشگر

• Computational Biology
• Machine Learning
• Genetic Epidemiology
• +۴ مورد دیگر

Craig A. Glastonbury is a Researcher and Research Group Leader at Human Technopole (since 2022), leading the Glastonbury Group. He holds a PhD in computational biology from King’s College London (2013-2017) and previously served as a machine learning researcher at BenevolentAI (2019-2022) and Postdoctoral Fellow at the University of Oxford (2017-2019). His work focuses on integrating machine learning with genetic and imaging data to uncover disease mechanisms, particularly in histopathology and cardiovascular phenotypes. He currently advises BenevolentAI and serves as a guest associate editor for AHA Circulation. Research interests include computational biology, histopathology imaging, GWAS, and single-cell RNA-seq. The Glastonbury Group develops methods to extract phenotypic traits from imaging modalities like whole slide imaging (WSI) and links these to genetic data to study disease pathways. Current projects involve analyzing large-scale biobank data to identify genetic contributions to complex diseases such as inflammatory bowel disease and oncology. Group members include PhD students Francesco Cisternino, Giuditta Clerici, Emma Esther Didelon, and Emanuel Soda, along with postdoctoral researchers and bioinformaticians. The team actively recruits for positions in machine learning, phenotyping, and genetic discovery. Craig’s work emphasizes scalable pipelines for GWAS and unsupervised phenotype discovery, with applications in cardiovascular and metabolic research. Contact: craig.glastonbury@fht.org

• Cardiac Conduction System
• Molecular Biology
• Electrophysiology
• +۵ مورد دیگر

Halina Dobrzynski is a Senior Lecturer in Cardiovascular Sciences at the University of Manchester, School of Medicine. She holds a visiting professor position at Jagiellonian University's Department of Anatomy (Cracow, Poland) and earned a D.Sc. from Jagiellonian University in 2023. Her research focuses on the macro/micro-anatomy and molecular biology of the cardiac conduction system, particularly the sinoatrial and atrioventricular nodes, using advanced imaging (microCT, AI, VR) and molecular techniques. She has supervised over 20 PhD students and postdocs, with active grants exceeding £7 million from BHF, NIH, and others. Key awards include the 2014 Best Pre-Clinical Teacher award at Manchester. Education: B.Sc. (1996) and Ph.D. (2000) in Biological/Biomedical Sciences from the University of Leeds. Postdoctoral roles at Leeds, NIH, Washington University, and others. Research interests emphasize structural-functional relationships in the cardiac conduction system across species (human, rodent, large animals) and conditions (aging, disease, exercise). Key projects include circadian rhythms in pacemaking, microRNA regulation of ion channels, and bio-pacemaker development. Over 138 publications span cardiac electrophysiology, imaging innovations, and translational cardiology. Active in grant review (BHF, NIH) and editorial roles (Frontiers in Physiology). Public engagement includes science outreach programs for youth and lectures on cardiac physiology. Teaching/admin roles include Radiation Protection Supervisor, Manchester Gold Mentor, and leadership in medical student education. Grants managed include £2.5M BHF PhD studentships and a £4.6M Leducq Network grant (2019-2024).

Gregory J. Auneمشاهده پروفایل

دانشیار

• Pediatric Oncology
• Cancer Survivorship
• Cardiotoxicity
• +۳ مورد دیگر

Dr. Gregory J. Aune is an Associate Professor of Pediatrics and a tenured faculty member at the University of Texas Health Science Center at San Antonio. He holds prestigious positions as the Greehey Distinguished University Chair for Cancer Survivorship in Children and the Stephanie Edlund Distinguished Professor of Pediatric Cancer Research. With over 30 years of experience in pediatric oncology, his research focuses on cardiotoxicity from cancer therapies, cancer survivorship, and social determinants of health. His lab developed a mouse model for anthracycline-induced cardiac toxicity and directs the Greehey Children’s Cancer Research Institute’s Cardiac Function Assessment Shared Resource. Dr. Aune’s clinical and research leadership includes roles in the South Texas Pediatric Cancer Survivorship Program and national task forces addressing chemotherapy-related cardiotoxicity. He is a prominent advocate for childhood cancer, raising over $1 million via St. Baldrick’s Foundation and For the Kids Dance Marathon. Internationally, he addressed the World Health Assembly in 2015, urging global prioritization of childhood cancer. His advocacy includes roles with the National Coalition for Cancer Survivorship, American Childhood Cancer Organization, and St. Baldrick’s National Advocacy Committee. Dr. Aune’s grants include funding from St. Baldrick’s, Hyundai, and NIH, supporting studies on cardiac MRI in survivors and mechanisms of anthracycline toxicity. His research integrates preclinical models, clinical care, and community engagement to address long-term health consequences of pediatric cancer therapies.

• Amyotrophic Lateral Sclerosis
• Neuromuscular Diseases
• Gene Therapy
• +۳ مورد دیگر

Robert H. Brown, MD, DPhil, is the Donna M. and Robert J. Manning Chair in Neurosciences and a Professor in the Department of Neurology at UMass Chan Medical School. He holds cross-appointments in Genetic and Cellular Medicine, NeuroNexus Institute, RNA Therapeutics Institute, and multiple graduate programs (Neuroscience, Translational Science). Education: BA in Biophysics (Amherst College) MD (Harvard Medical School) DPhil in Neurophysiology (University of Oxford) His research focuses on molecular pathogenesis of neuromuscular diseases, including amyotrophic lateral sclerosis (ALS), muscular dystrophy, and hereditary neuropathies. He develops gene-targeted therapies using antisense oligonucleotides and RNAi to silence disease-causing mutations (e.g., SOD1, C9ORF72). His lab creates transgenic mouse models to validate therapeutic strategies and investigate neurodegeneration mechanisms. Recent publications (2023–2025) emphasize RNAi therapeutics, antisense oligonucleotide optimization, and biomarker discovery for ALS. Key themes include SOD1/C9ORF72 silencing, neuroprotection pathways, and mitigating side effects of gene therapies. Over 70% of articles involve preclinical/clinical translational research. He directs the Brown Lab , which collaborates globally on neurodegenerative disease projects. Current work prioritizes refining CNS-targeted delivery of gene therapies and elucidating trauma-induced neurodegeneration links.

• Mitochondrial Biology
• Neuroscience
• Cancer Biology
• +۷ مورد دیگر

Brooke Erika Hjelm is an Assistant Professor of Clinical Cancer Biology at the University of Southern California. She holds the role of Culture and Engagement Champion, contributing to academic and institutional culture. Her research focuses on mitochondrial biology, psychiatric disorders, neurodegenerative diseases, and molecular mechanisms in cancer and autoimmune conditions. She has published extensively on topics such as mitochondrial DNA deletions, synaptic pathology in Alzheimer’s, and biomarker discovery for conditions like Sjögren’s syndrome and schizophrenia. Her work integrates cutting-edge technologies like single-cell RNA sequencing and iPSC-derived models to study disease mechanisms. Key areas of investigation include the role of mitochondrial dysfunction in schizophrenia and bipolar disorder, genetic mutations in congenital heart defects, and the development of diagnostic biomarkers using miRNA profiling. She has contributed to translational initiatives such as the Foundational Data Initiative for Parkinson’s Disease, bridging genetic maps with clinical mechanisms. No scientific awards are explicitly listed in the provided text. While no student advisees are mentioned, her research collaborations span interdisciplinary teams addressing complex biological systems. Her work emphasizes the interplay between genetic, molecular, and environmental factors in disease pathogenesis.

Elizabeth Meieringمشاهده پروفایل

استاد

• Protein Folding
• Protein Dynamics
• Protein Function
• +۴ مورد دیگر

Elizabeth Meiering is a Full Professor in the Department of Chemistry at the University of Waterloo, Canada. Her research focuses on understanding protein folding, dynamics, function, engineering, and design, with applications in biotechnology and medical science. She holds a BSc in Honours Chemistry from the University of Waterloo (1988), a PhD in Biological Chemistry from the University of Cambridge (1992), and completed postdoctoral training at Harvard Medical School (1992–1996). Her work integrates experimental techniques (e.g., NMR spectroscopy, calorimetry, and molecular dynamics) with computational modeling to study proteins like Hisactophilin, ThreeFoil, Adnectins, and ALS-linked SOD1. Key projects include investigating pH-dependent actin/membrane binding, designing multivalent carbohydrate-binding proteins, enhancing protein biologic stability, and studying SOD1 misfolding in ALS. Dr. Meiering has received the John Charles Polanyi Award and a University Research Chair. She actively serves on editorial and advisory boards, including the Protein Engineering Design and Selection journal and the ALS Society of Canada. She has held roles such as Associate Dean of Graduate Studies at Waterloo and chaired the Proteins Gordon Research Conference. Her lab, the Protein Folding Laboratory , explores protein behavior in health and disease, emphasizing translational applications in biotechnology and medicine. Recent publications highlight advancements in structural analysis, aggregation mechanisms, and computational modeling of protein stability.

Magnus Johanssonمشاهده پروفایل

استاد

• Molecular Virology
• Flavivirus Research
• Vaccine Development
• +۳ مورد دیگر

Magnus Johansson is a Professor of Biomedicine at Örebro University, affiliated with the School of Medical Sciences and the Department of Medical Sciences. He holds a PhD in biochemistry from Stockholm University (1998) and became a professor in 2017. His research focuses on flaviviruses, particularly tick-borne encephalitis virus (TBEV), investigating viral replication mechanisms, host immune interactions, and vaccine development. He has pioneered studies on TBEV NS5 protein’s role in evading host immunity and developed replicon models for vaccine design. Education: PhD in Biochemistry (Stockholm University, 1998), Postdoc at James Cook University (Australia, 1999), Docent in Biochemistry (Södertörn University, 2007). Leadership roles include Deputy Head of the School of Medical Sciences (since 2015) and completion of the MAL leadership program (2008). Research highlights include molecular epidemiology of TBEV, surveillance strategies using dairy milk, and prime-boost vaccination approaches. His work spans infectious disease control, with collaborative projects on edible vaccines and flavivirus biodiversity. He leads research groups in Cellular and Molecular Virology and the Inflammatory Response and Infection Susceptibility Centre (iRiSC). Recent projects: 'Developvaccines@oru', 'Molecular epidemiology of TBEV', and 'NOVEL PRIME-BOOST STRATEGIES'. Over 70 peer-reviewed publications, with a focus on TBEV, Zika, and dengue virus biology.

Matthew Hirnمشاهده پروفایل

دانشیار

• computational mathematics
• harmonic analysis
• data science
• +۷ مورد دیگر

Matthew Hirn is a computational mathematician with expertise in harmonic analysis, data science, and machine learning. He was a tenured Associate Professor at Michigan State University (MSU), jointly appointed in the Department of Computational Mathematics, Science & Engineering and the Department of Mathematics. As the scientific leader of the ComplEx Data Analysis Research (CEDAR) Team at MSU, he developed innovative methods for analyzing complex data, including wavelet scattering transforms for atomistic systems and geometric deep learning techniques. He is currently a Senior Quantitative Researcher at Citadel LLC, contributing to algorithmic trading strategies. His research bridges theoretical mathematics and applied data science, with notable contributions to graph neural networks, scattering transforms, and privacy-preserving methods. His academic career included organizing conferences such as the SIAM Mathematics of Data Science mini-symposium on geometric learning and co-authoring influential software like the Kymatio library for wavelet scattering transforms. He advised PhD students Ryan LaRose, Xavier Brumwell, and Jieqian He, who have since pursued impactful roles in academia and industry. His work on 3D wavelet scattering networks for material science and geometric scattering on manifolds has advanced the intersection of mathematics and machine learning. Matthew’s research interests span signal processing, graph representation learning, and applications in bioinformatics and many-particle physics. He has published extensively in top journals and conferences, including the Journal of Chemical Physics and the Journal of Machine Learning Research.

• HIV-1 persistence
• HIV-induced immune dysfunction
• Single-cell genomics
• +۵ مورد دیگر

Ya-Chi Ho is an Associate Professor in the Department of Microbial Pathogenesis at the Yale School of Medicine. She serves as Director of Graduate Studies for the Microbiology PhD Program within the Biological and Biomedical Sciences (BBS) program. Her research focuses on understanding HIV-1 persistence and immune dysfunction using cutting-edge single-cell genomic approaches. Dr. Ho holds secondary appointments in the Departments of Immunology, Infectious Diseases, and Virology Laboratories at Yale, and collaborates with initiatives like the NIH Structural Biology Center CHEETAH and the Martin Delaney Collaboratory. Education: MD from National Cheng Kung University (2002), residency and fellowship in Internal Medicine and Infectious Diseases at National Taiwan University Hospital (2005–2007), PhD in Cellular and Molecular Medicine from Johns Hopkins University (2013), and postdoctoral training at Johns Hopkins School of Medicine (2014). Research Interests: Dr. Ho’s lab investigates mechanisms of HIV persistence, particularly clonal expansion of latently infected cells and HIV-driven transcriptional dysregulation. Key projects include single-cell multi-omic profiling of HIV reservoirs, CRISPR-based screens for latency reversal, and translational drug discovery targeting aberrant gene expression. Recent findings highlight the role of cytotoxic CD4+ T cells and tissue resident memory programs in HIV persistence. Awards: Notable honors include the Andy Kaplan Prize (2018), Gilead Sciences Research Scholar Award (2018), and NIH R01 grants. Her work has been published in Immunity , Science Translational Medicine , and Cell Host & Microbe . Grants & Collaborations: NIH-funded projects (R01, UM1, P01) support her research. Current clinical trials investigate mechanisms of HIV latency and interventions targeting the latent reservoir. Labs & Infrastructure: Director of the Ya-Chi Ho Lab at the Boyer Center for Molecular Medicine. Collaborates with the Yale Cancer Center and Center for RNA Science and Medicine.

Sean Limesandمشاهده پروفایل

استاد

• Fetal Development
• Endocrinology
• Animal Physiology
• +۳ مورد دیگر

Sean Limesand, PhD is a Professor at the University of Arizona's School of Animal Sciences & Comparative Biomedical Sciences. His research focuses on fetal development, endocrine adaptations, and metabolic programming in animal models, particularly sheep and goats. Key areas include fetal growth restriction (FGR), placental insufficiency, and the long-term impacts of in utero stressors like hypoxia, heat, and maternal infections. His work integrates molecular biology (e.g., transcriptomics), cellular physiology (e.g., β-cell function), and whole-animal studies. Notable contributions include identifying dysregulated pathways in growth-restricted fetal tissues, characterizing mitochondrial adaptations in FGR, and exploring therapeutic interventions (e.g., oxygen/glucose therapy in ovine models). Research also addresses environmental challenges like maternal heat stress and its effects on lactation/placental function, as well as SARS-CoV-2's impact on maternal-neonatal outcomes. His studies often involve interdisciplinary approaches, combining omics technologies with physiological measurements to understand developmental origins of health and disease. Current studies investigate single-cell transcriptomics of SS-cells in FGR, epigenetic modifications in thermotolerant ewes, and molecular mechanisms linking fetal programming to adult metabolic disorders. These efforts aim to translate findings into clinical strategies for managing growth-restricted infants and improving livestock resilience.

• Pulmonary Medicine
• Immunology
• Mitochondrial Biology
• +۳ مورد دیگر

Min-Jong Kang is an Associate Professor of Medicine in the Department of Pulmonary, Critical Care & Sleep Medicine at Yale School of Medicine. He holds appointments in the CPIRT Center for Pulmonary Injury, Inflammation, Repair and Therapeutics. His research focuses on mitochondrial dysfunction and innate immunity in aging-related lung diseases like COPD and IPF, with a particular interest in the MAVS protein's role in host resilience. He earned his MD from Seoul National University (1991), PhD (2002) and MPH (1999) from the same institution. Research Interests: Dr. Kang investigates how mitochondrial biology intersects with aging and immune dysregulation. His work explores mechanisms linking mitochondrial antiviral signaling proteins (MAVS) to chronic lung diseases, including how cellular senescence and mitochondrial dysfunction drive disease progression. Current projects include studying MIF-CD74 signaling in pulmonary fibrosis and mitochondrial non-coding RNAs' protective roles against cigarette smoke injury. Laboratory: The Kang Lab focuses on translational research to identify novel therapeutic targets for COPD and IPF. Recent work highlights the potential of targeting VISTA immune regulators and mitochondrial retrograde signaling pathways. Dr. Kang collaborates with leading researchers like Naftali Kaminski and Maor Sauler on multi-disciplinary studies. Future Directions: His team aims to bridge aging biology with pulmonary medicine, developing interventions that improve mitochondrial health to combat age-related lung pathologies. Ongoing studies explore senescence markers and mitochondrial quality control mechanisms in lung aging.

• Virology
• Immunology
• Infectious Diseases
• +۳ مورد دیگر

Penghua Wang is an Adjunct Assistant Professor in the Department of Infectious Diseases at Yale School of Medicine. He holds a PhD from the National University of Singapore (2006) and a BA from ZhongShan Medical University (1992). His research focuses on host-pathogen interactions, particularly RNA viruses, and explores mechanisms of viral pathogenesis and immune evasion. Key interests include innate immunity, antiviral immune responses, and viral life cycles. Education: PhD, National University of Singapore (2006) BA, ZhongShan Medical University (1992) His research investigates viral pathogens such as West Nile virus, Dengue virus, and Hepatitis C virus. Recent work includes identifying host factors influencing viral pathogenesis, such as NLRs and UBXNs, and elucidating mechanisms of immune evasion. Collaborations with researchers like Erol Fikrig and Ruth R. Montgomery have yielded studies on antiviral signaling, symbiotic bacteria’s role in flavivirus transmission, and SARS-CoV-2 evolution. Publications highlight advancements in understanding cGAS-STING signaling in kidney inflammation, integrin clustering, and mosquito-borne pathogen transmission dynamics. His lab is located at The Anlyan Center, 300 Cedar Street, Ste S410, New Haven, CT 06519.

• Oncology
• Lung Cancer
• Drug Resistance Mechanisms
• +۳ مورد دیگر

Zachary Yochum, MD, PhD, is a Clinical Assistant Professor in the Department of Internal Medicine at Yale School of Medicine, specializing in Medical Oncology and Hematology. His research focuses on molecular mechanisms of drug resistance in oncogene-driven cancers, particularly lung and renal cell carcinomas, with an emphasis on EMT transcription factors (TWIST1, ZEB1), HGF/MET pathways, and novel therapeutic strategies. Yochum holds a BS from the University of Notre Dame (2012), MD and PhD from the University of Pittsburgh School of Medicine (2020). He completed residency at Brigham and Women's Hospital and a postdoctoral fellowship funded by the HHMI Medical Research Fellowship and NIH grants. His research interests include developing targeted therapies against EGFR inhibitor resistance, immunotherapy rechallenge strategies, and understanding circRNA regulation in tumor progression. He has published widely in journals like Oncogene , Clinical Cancer Research , and The Lancet . Awards : HHMI Medical Research Fellowship (2014), F30 Ruth L. Kirschstein Fellowship (2017), Alpha Omega Alpha (2019) Yochum collaborates with teams investigating tumor microenvironment interactions, MET pathway activation, and biomarker-driven clinical trials. He is part of translational research initiatives at Yale focused on precision oncology and drug resistance mechanisms.

• Transcription Factor Regulation
• Genetics
• Molecular Biology
• +۳ مورد دیگر

Michelle Kudron is an Associate Research Scientist in the Department of Genetics at Yale School of Medicine. She holds a PhD in Genetics from Yale University (2009) and an AB in Biology from Smith College (2002). Her research focuses on transcription factor regulation in C. elegans , particularly their roles in tissue-specific and global gene expression programs. She pioneered the first in-depth examination of tissue-specific binding of the Rb/E2F pathway in vivo and is a key contributor to the modERN project, which maps transcription factor binding sites across model organisms. Education: PhD in Genetics, Yale University (2009); AB in Biology, Smith College (2002) Research Interests: Transcriptional regulation, developmental biology, genomics, and C. elegans genetics Labs/Teams: Collaborates with Valerie Reinke, Mark Gerstein, and others in interdisciplinary teams Her work integrates experimental and computational approaches to uncover regulatory networks underlying developmental and cellular processes. Major contributions include defining tissue-specific regulatory relationships and advancing methodologies in ChIP-seq analysis.

• Cell and Molecular Biology
• Discipline-Based Educational Research
• Virology
• +۳ مورد دیگر

Christopher Jang is an Associate Professor in the Department of Biology at York University and Director of Academic Support Programs at Bethune College. He holds a Ph.D. in Biochemistry and Molecular Biology from the University of British Columbia and completed postdoctoral research at the University of Pennsylvania focusing on sleep and circadian rhythms. His research spans cell/molecular biology and discipline-based educational research, emphasizing innovative pedagogy and inclusive teaching practices. He has designed undergraduate research experiences and developed courses in biochemistry and pharmacology. Education: B.Sc. Biochemistry (Queen’s University), Ph.D. Biochemistry & Molecular Biology (UBC) His teaching philosophy centers on making complex biological concepts accessible, reflected in his award-winning York University Faculty of Science Excellence in Teaching Award (2023). He has contributed to public science advocacy through roles at Bad Science Watch and science outreach at institutions like the Franklin Institute. Research interests include viral translational control mechanisms, circadian biology, and educational strategies to enhance STEM equity. He has published on topics ranging from viral IRES structures to circadian gene expression regulation. Awards: Departmental Best Graduate Seminar Award, AMS Biology Teaching Fellowship Teaching highlights include founding a course-based undergraduate research program in molecular biology and leading interdisciplinary initiatives at Haverford College and the University of Pennsylvania.