جستجوی استاد راهنمای دانشگاهی

Rueyling Linمشاهده پروفایل

استاد

• Developmental Biology
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Dr. Rueyling Lin is a Professor in the Department of Molecular Biology at UT Southwestern Medical Center. She earned her Ph.D. in Biochemistry under Drs. C. David Allis and Stephen Elledge at Baylor College of Medicine, followed by postdoctoral training with Dr. Jim Priess at the Fred Hutchinson Cancer Research Center. Research Interests: Her work focuses on the molecular mechanisms governing the oocyte-to-embryo transition and early cell fate specification in Caenorhabditis elegans , with emphasis on Wnt signaling, RNA-binding proteins, and transcriptional repression. She has contributed to understanding how maternal factors regulate embryonic development through translational control and protein interactions. Key Publications: 15 seminal studies spanning 2001–2017 on topics like maternal mRNA translation, TFEB pathway agonists, and Wnt/Notch signaling dynamics. Leadership Roles: After 16 years as a faculty member, she joined the Howard Hughes Medical Institute (HHMI) in 2019 as a Scientific Officer. In 2023, she returned to UT Southwestern as Associate Dean for Biomedical Research Recruitment & Advancement, leading recruitment for programs like CPRIT and STARS while coordinating award nominations and external funding.

• Immunology
• Allergy Mechanisms
• Asthma Pathogenesis
• +۶ مورد دیگر

Manel Jordana is a Professor in the Department of Medicine at McMaster University, specializing in immunology and allergy research. His work focuses on understanding immune mechanisms underlying allergic diseases, particularly food allergies, asthma, and anaphylaxis. He has contributed extensively to studies on cytokine networks (e.g., IL-4, IL-13), T and B cell biology, and the role of microbiota in immune responses. His research bridges basic science and clinical applications, including clinical trials on oral immunotherapy for peanut allergy. Key areas of research include: food allergy pathogenesis, IgE memory persistence, microbial regulation of immune responses, and the role of T follicular helper cells. His studies often explore mechanisms of immune tolerance and anaphylaxis prevention. He collaborates widely on translational projects targeting Th2 immunity pathways and allergen-specific immune modulation. Notable contributions include defining the role of GM-CSF and IL-33 in allergic inflammation, elucidating mechanisms of IgE memory reservoirs, and investigating microbiota-driven modulation of enteric eosinophils. His work has advanced understanding of how viral infections influence allergic sensitization trajectories and airway remodeling.

• Developmental Biology
• Molecular Genetics
• Neurogenetics
• +۴ مورد دیگر

Ana Regina Campos is Professor of Interdisciplinary Science in the Department of Biology at McMaster University, Canada. Over four decades she has integrated developmental genetics, neurobiology and environmental toxicology, exploiting Drosophila melanogaster and Hydra models to uncover how genes regulate neural connectivity, behaviour, stress responses and regeneration. Education: Ph.D. Developmental Genetics, Brandeis University M.Sc. Molecular Biology, Federal University of Rio de Janeiro Research thrusts span (i) neural-specific gene expression and visual-system wiring in Drosophila , (ii) mitochondrial DNA polymerase function and organismal behaviour, (iii) menin-mediated stress signalling and genome stability, and (iv) eco-toxicological impacts of pharmaceuticals on cnidarian regeneration. Methodologically she combines classical mutagenesis, transgenic tools (UAS/GAL4, RNAi), kinematic behavioural assays and pharmacological screens. Her publication trajectory (41 works, 1975-2024) clusters in developmental biology, molecular biology methods, genetics and cellular neuroscience, with recent papers addressing environmental stressors and renal physiology. Teaching commitments are extensive: since 2018 she has instructed 20 different courses ranging from first-year inquiry to senior theses, laboratory methods, science communication, applied placements and a specialized fourth-year seminar on regeneration. No grants, doctoral students or major scientific awards are listed in the current repository extract; co-author networks at McMaster include Rodriguez-Moncalvo, O’Donnell, Bedard and Wilson.

Sara Prescottمشاهده پروفایل

استادیار

• Neuroscience
• Molecular Biology
• Developmental Biology
• +۳ مورد دیگر

Sara Prescott is an Assistant Professor of Biology at the Massachusetts Institute of Technology (MIT) and an Investigator at the Picower Institute for Learning and Memory. Her research focuses on understanding neural circuits and genetic mechanisms underlying sensory pathways, developmental processes, and evolutionary biology. She holds a joint faculty appointment in MIT's School of Science, contributing to interdisciplinary collaborations across neuroscience and molecular biology. Her work explores topics such as how sensory systems detect and respond to internal and external stimuli, including mechanisms of nausea, influenza-induced sickness behaviors, and arterial pressure regulation. Prescott also investigates genetic variation in enhancer regions, particularly in neural crest cells, to uncover evolutionary and developmental principles. She develops analytical tools like FaceBase to advance craniofacial research through FAIR data standards. Prescott's research straddles molecular, cellular, and systems-level biology, with implications for understanding both normal physiological processes and disease mechanisms. Her work frequently integrates experimental and computational approaches to dissect complex biological systems.

• Mathematical Biology
• Genomics
• Bioinformatics
• +۳ مورد دیگر

Indika Rajapakse is a Professor of Mathematics and affiliated as a Professor of Computational Medicine and Bioinformatics at the University of Michigan. His primary affiliation is with the Department of Mathematics within the College of Literature, Science, and the Arts (LSA). He can be reached at indikar@umich.edu . Rajapakse’s research bridges mathematical theory and biomedical applications, focusing on genomic organization, hypergraph modeling, and computational methods for cell reprogramming and disease analysis. His research interests include mathematical biology , genomics , and systems biology , with a particular emphasis on understanding how genome architecture influences cellular identity and function. He develops tools like the 4DNvestigator and Bioinformatics Retrieval Augmentation Data (BRAD) system to analyze genomic and transcriptomic data. His work also explores machine learning applications in medicine, such as adversarial immune-inspired learning systems and language model integration in digital biology. Rajapakse’s publications highlight trends in hypergraph theory for biological networks, dynamic sensor selection for biomarkers, and computational platforms for medical research. He has contributed to studies on obesity-driven immune network disruptions, lineage-specific chromosomal topologies, and the role of macrophages in diabetes. His research often combines mathematical frameworks with experimental biology to address clinical and theoretical challenges. He advises students through the Mathematics department at U-M and collaborates on grants related to genome dynamics and computational medicine. Notable projects include developing the SEWAL platform for genomic data analysis and exploring the 4D Nucleome’s functional organization. Rajapakse’s interdisciplinary work advances both fundamental biology and translational medical research.

• Developmental Genomics
• Evolutionary Biology
• Molecular Genetics
• +۶ مورد دیگر

Marco Trizzino is an Associate Professor in the Department of Life Sciences at Imperial College London (Faculty of Natural Sciences). He previously held positions as Assistant Professor and Adjunct Professor at Thomas Jefferson University. His research focuses on developmental and evolutionary genomics, integrating experimental and computational approaches to study transposable elements' roles in human-specific traits, neurodevelopmental disorders, and lifespan evolution. Key projects include investigations into craniofacial development, neural crest cell specification, and the molecular basis of syndromes caused by chromatin-associated gene mutations. Education: PhD from Sapienza University of Rome, followed by postdoctoral training at the University of Pennsylvania and The Wistar Institute. He leads a lab relocating to Imperial College in 2022, supported by grants from MRC, NIH, BBSRC, and the Alzheimer's Association. Recent grants include studies on CHD3 in craniofacial development (collaboration with King's College) and transposable elements in ALS (with Thomas Jefferson University). Research Interests: His lab uses induced pluripotent stem cells (iPSCs) from primates and patients to model neural crest and neural lineages. Key topics include transposable elements' contributions to gene regulatory networks, epigenetic dysregulation in syndromes, and mechanisms linking chromatin mutations to craniofacial/neural defects. He also explores lifespan differences among mammals, combining evolutionary genomics with molecular biology. Lab Members: Current advisees include PhD students Zoe Mitchell and Martina Demurtas, and postdoc Laura Deelen. Sam Barnada recently completed her PhD. Collaborators include Prof. Karen Liu (King's College) and Prof. Davide Trotti (Thomas Jefferson University). Grants & Awards: Recent funding includes a 5-year NIH-R01 grant (2024), MRC funding for CHD3 research (2025), and BBSRC support for transposable element studies (2023). The lab's work addresses translational applications in neurodegenerative diseases and developmental syndromes.

John T Lisمشاهده پروفایل

استاد

• Molecular Biology
• Genetics
• Gene Regulation
• +۷ مورد دیگر

John T. Lis is the Barbara McClintock Professor of Molecular Biology and Genetics at Cornell University's College of Agriculture and Life Sciences (CALS). He obtained his Ph.D. in Biochemistry from Brandeis University (1975) and conducted postdoctoral research at Stanford University on Drosophila gene regulation. Since joining Cornell in 1978, his research has focused on transcriptional regulation, chromatin structure, and RNA polymerase dynamics, supported by grants from the NIH, March of Dimes, and Proctor & Gamble. His work has pioneered techniques like PRO-seq for mapping transcriptional activity. **Research Interests:** Lis’s lab investigates gene expression control mechanisms, including enhancer/promoter function, transcriptional pausing, and stress responses. Key areas include the role of transcriptional checkpoints (e.g., NELF-Cdk9), epigenetic regulation, and the interplay between chromatin architecture and transcription. Recent studies explore transcriptional memory, viral-host interactions (e.g., SARS-CoV-2), and cancer-related transcriptional dysregulation. **Awards & Grants:** He is a 2013 Fellow of the American Academy of Arts and Sciences and recipient of the NIH MERIT Award. His lab secured a $33M grant for Academic Integration efforts (2021), advancing collaborative research in computational biology and genomics. **Advancing Science:** Lis has developed groundbreaking methods like PRO-IP-seq and Femto-Seq to study RNA polymerase modifications and chromatin contacts. His work bridges basic science and translational research, addressing questions in cancer biology, viral pathogenesis, and developmental genetics.

Tudorita Tumbarمشاهده پروفایل

استاد

• Stem Cell Biology
• Epithelial Stem Cells
• Hair Follicle Development
• +۵ مورد دیگر

Tudorita Tumbar is a Professor in the Department of Molecular Biology and Genetics at Cornell University, within the College of Agriculture and Life Sciences (CALS). Her research focuses on molecular mechanisms governing stem cell behavior in skin, particularly hair follicle and epidermal stem cells. She employs genetic and genomic tools to explore how intrinsic factors (e.g., transcriptional regulation, epigenetics) and extrinsic signals (e.g., niche interactions) regulate stem cell fate in development and disease. Education: PhD in Cell Biology (University of Illinois, 2000), BS/MS in Biochemistry (University of Bucharest, 1993). Teaching: Courses include Introductory Cell and Developmental Biology and Stem Cells and Regeneration. Awards: Humboldt Research Award (2020). Labs/Teams: Tumbar Lab of Tissue Stem Cell Biology, collaborating with institutions like Cologne University. Grants: NIH-funded projects on skin stem cell niches and regeneration. Research Interests: Hair follicle stem cells, epigenetic regulation, skin wound healing, vascular-niche interactions, and mechanisms underlying tissue homeostasis. Her work bridges basic biology with translational applications in regenerative medicine and cancer research. Lab Activities: Training undergraduate and graduate students, postdocs, and managing NIH-funded projects. Recent studies include vascular signaling in stem cell activation (EMBO J, 2023) and niche heterogeneity in skin protection (EMBO J, 2022).

• Cardiovascular Disease
• Systems Biology
• Single-cell Omics
• +۶ مورد دیگر

Associate Professor Alexander Pinto is a co-appointed faculty member between La Trobe University and the Baker Heart and Diabetes Institute, leading the Cardiac Cellular Systems laboratory. His research focuses on understanding how cellular networks in the heart contribute to heart failure, particularly under conditions like hypertension, obesity, and diabetes. He employs cutting-edge methods including single-cell omics, 3D imaging, and mouse genetics to explore reversible cardiac alterations. Research Interests: Cardiovascular disease mechanisms Systems biology and computational biology Single-cell genomics and transcriptomics 3D microscopy and imaging techniques Cellular interactions in fibrosis Sex-specific pathophysiology Recent Research Trends: His work emphasizes multi-omic analyses of cardiac non-myocytes, sex-specific responses to hypertension, and adipose tissue contributions to cardiovascular disease. Notable contributions include identifying novel drivers of vascular fibrosis and embryonic-derived progenitor cells in aorta development. Grants: Heart Foundation of Australia Future Leader Fellowship (2024–2027) NHMRC Ideas Grant (2020–2023) Collaborations involve labs in Australia and the U.S., with a focus on translational cardiovascular research.

Michael V Zaragozaمشاهده پروفایل

دانشیار

• Cardiovascular Genetics
• Stem Cell Biology
• Nuclear Lamina Disorders
• +۵ مورد دیگر

Dr. Michael V. Zaragoza is an Associate Professor of Pediatrics at the University of California, Irvine School of Medicine with joint appointments in Biological Chemistry. He serves as faculty at the Center for Complex Biological Systems and the Sue and Bill Gross Stem Cell Research Center. His research investigates genetic heart diseases, particularly LMNA-related dilated cardiomyopathy, using patient-derived iPSC models to understand disease mechanisms. His laboratory integrates approaches from: Stem cell biology and differentiation protocols Single-cell transcriptomics and epigenomics Cardiac tissue engineering and biomechanics Computational biology and bioinformatics Dr. Zaragoza's recent work has revealed how lamin A/C haploinsufficiency disrupts cardiac development programs through epigenetic dysregulation and cell lineage-specific gene expression changes. His NIH-funded research has identified epimutation hotspots in laminopathy patients and developed advanced database systems for managing multidimensional tissue engineering data. He maintains active collaborations with bioengineers, computational biologists, and clinical researchers to translate basic science findings into potential therapeutic strategies for genetic cardiomyopathies.

Jamie Wikenheiserمشاهده پروفایل

استاد مدعو

• Anatomy
• Urology
• Developmental Biology
• +۴ مورد دیگر

Dr. Jamie Wikenheiser is an Adjunct Professor in the Department of Anatomy & Neurobiology at the University of California, Irvine. Her research focuses on anatomical and developmental studies, particularly in autonomic nervous system distribution, congenital heart defects, and the effects of toxicants on cardiovascular development. She has contributed to groundbreaking work using 3D imaging techniques to map nerve distributions in the human ureter and bladder, as well as investigating the role of HIF-1α in coronary vessel formation. Her interdisciplinary approach bridges anatomy, genetics, and environmental science, with notable publications in journals like J Urol and Developmental Dynamics . Key areas of expertise include: Autonomic nerve anatomy of urogenital systems Mouse models of congenital heart defects Toxicological effects of environmental agents on cardiovascular development Lymphatic and vascular development in embryology Recent work has emphasized the application of advanced imaging and genetic tools to understand tissue-specific neural and vascular patterning, contributing to both basic science and clinical surgical practices.

Arvind Merمشاهده پروفایل

استادیار

• Computational Biology
• Bioinformatics
• Machine Learning
• +۸ مورد دیگر

Dr. Arvind Mer is an Assistant Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. He holds a B.Tech from Dr. APJAK Technical University (2007), M.Tech from Jawaharlal Nehru University (2009), and a PhD from the Max Delbrück Center for Molecular Medicine and Freie Universität Berlin (2014). His postdoctoral training included stints at the Karolinska Institute (Sweden) and University Health Network (Toronto). He joined the University of Ottawa in 2021. His research focuses on leveraging machine learning and artificial intelligence to analyze high-throughput omics data for advancing personalized medicine. Key areas include: Developing computational methods for single-cell sequencing analysis Identifying biomarkers for cancer drug response prediction Exploring drug repurposing strategies using pharmacogenomic data Understanding therapeutic resistance mechanisms in leukemia and breast cancer Dr. Mer's lab integrates multi-omics datasets with clinical outcomes to improve treatment precision. His work has produced open-source tools like PharmacoDB 2.0 and contributed to novel insights into AML subtypes and drug-tolerant persister cells. He has advised multiple postdoctoral fellows and students interested in computational biology and bioinformatics. His research has been published in journals such as Nature Communications, Cancer Research, and Scientific Reports.

Rance Naultمشاهده پروفایل

استادیار

• Computational Biology
• Genomics
• Environmental Toxicology
• +۶ مورد دیگر

Rance Nault, PhD, is an Assistant Professor in the Department of Pharmacology & Toxicology at Michigan State University (MSU), affiliated with the College of Osteopathic Medicine. His research focuses on integrating computational methods with experimental toxicology to study chemical/drug effects on liver disease progression, particularly using single-cell transcriptomics and spatial transcriptomics. He holds a PhD from MSU (2016) and an MSc from the University of Ottawa (2011). Key research interests include mechanotransduction in perivascular adipose tissue (PVAT), TCDD-induced metabolic reprogramming, and FAIR data standards in environmental health. His lab develops tools like metabolic network-based machine learning models to predict toxicant effects. Recent work explores high-fat diet impacts on PVAT cell composition and AHR-mediated signaling pathways. He teaches PHM 838: Pharmacogenomics (online) and advises the Nault Lab, located in the Life Sciences Building. Employment spans MSU from 2021, with prior roles in toxicogenomics and environmental contaminant research. His work bridges computational biology, genomics, and translational toxicology to advance personalized health strategies.

Stephen Crewsمشاهده پروفایل

استاد مدعو

• Developmental Biology
• Molecular Biology
• Neuroscience
• +۴ مورد دیگر

Stephen Crews is an Adjunct Professor in the Department of Biology at the University of North Carolina at Chapel Hill, with an affiliation as Professor of Biochemistry & Biophysics. His research focuses on the molecular mechanisms governing Drosophila central nervous system (CNS) development, including neuron and glia differentiation, transcriptional regulation during neurogenesis, and the application of genomic technologies to study CNS subpopulations. Key topics include midline cell lineage specification, enhancer diversity, and transcription factor interactions. Research Interests: Developmental mechanisms of Drosophila CNS neurons and glia Transcriptional regulation during neurogenesis and gliogenesis Functional analysis of enhancers and cis-regulatory modules Genomic profiling of CNS subpopulations Role of signaling pathways (e.g., Hedgehog, Notch) in cell fate decisions Lab Website: Link (currently deactivated). Contact: steve_crews@unc.edu, 2151 Genome Sciences Building.

Joseph Burclaffمشاهده پروفایل

دانشگاهی

• Regenerative Medicine
• Cellular Metabolism
• Intestinal Stem Cells
• +۳ مورد دیگر

Dr. Joseph Burclaff is a Research Assistant Professor in the Lampe Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill. He holds a Ph.D. from Washington University in St. Louis (2019) and a B.S. from Marquette University (2013). His research focuses on understanding how proliferative populations in human intestinal crypts regulate their proliferation and cell fate decisions, particularly through transcriptional regulators of epithelial metabolism. He joined UNC Chapel Hill in 2019 as a Postdoctoral Research Fellow under Dr. Scott T. Magness and transitioned to his current role in 2022. His work integrates live imaging of primary human intestinal stem cells, microphysiological systems modeling, single-cell transcriptomics, and genetic manipulation techniques to study mechanisms in regenerative medicine, epithelial biology, and metabolic regulation. Notable projects include investigating sex-specific colonic inflammation pathways and developing platforms to quantify cell cycle dynamics in intestinal epithelial cells. Dr. Burclaff’s research has produced over 30 peer-reviewed articles since 2018, emphasizing metabolic regulators like SOX9 and ERRγ, cellular plasticity programs like cathartocytosis, and novel in vitro models for studying intestinal and gastric pathologies. His work bridges basic science and translational medicine, with implications for gastrointestinal diseases and regenerative therapies. No scientific awards or grants are explicitly listed, though his prolific publication record underscores active research engagement. He advises no listed students but collaborates with labs focused on stem cell biology and biomedical engineering.