معرفی
Manel Jordana is a Professor in the Department of Medicine at McMaster University, specializing in immunology and allergy research. His work focuses on understanding immune mechanisms underlying allergic diseases, particularly food allergies, asthma, and anaphylaxis. He has contributed extensively to studies on cytokine networks (e.g., IL-4, IL-13), T and B cell biology, and the role of microbiota in immune responses. His research bridges basic science and clinical applications, including clinical trials on oral immunotherapy for peanut allergy.
Key areas of research include: food allergy pathogenesis, IgE memory persistence, microbial regulation of immune responses, and the role of T follicular helper cells. His studies often explore mechanisms of immune tolerance and anaphylaxis prevention. He collaborates widely on translational projects targeting Th2 immunity pathways and allergen-specific immune modulation.
Notable contributions include defining the role of GM-CSF and IL-33 in allergic inflammation, elucidating mechanisms of IgE memory reservoirs, and investigating microbiota-driven modulation of enteric eosinophils. His work has advanced understanding of how viral infections influence allergic sensitization trajectories and airway remodeling.
