Rance Nault

Rance Nault, PhD, is an Assistant Professor in the Department of Pharmacology & Toxicology at Michigan State University (MSU), affiliated with the College of Osteopathic Medicine. His research focuses on integrating computational methods with experimental toxicology to study chemical/drug effects on liver disease progression, particularly using single-cell transcriptomics and spatial transcriptomics. He holds a PhD from MSU (2016) and an MSc from the University of Ottawa (2011).

Key research interests include mechanotransduction in perivascular adipose tissue (PVAT), TCDD-induced metabolic reprogramming, and FAIR data standards in environmental health. His lab develops tools like metabolic network-based machine learning models to predict toxicant effects. Recent work explores high-fat diet impacts on PVAT cell composition and AHR-mediated signaling pathways.

He teaches PHM 838: Pharmacogenomics (online) and advises the Nault Lab, located in the Life Sciences Building. Employment spans MSU from 2021, with prior roles in toxicogenomics and environmental contaminant research. His work bridges computational biology, genomics, and translational toxicology to advance personalized health strategies.