معرفی
John T. Lis is the Barbara McClintock Professor of Molecular Biology and Genetics at Cornell University's College of Agriculture and Life Sciences (CALS). He obtained his Ph.D. in Biochemistry from Brandeis University (1975) and conducted postdoctoral research at Stanford University on Drosophila gene regulation. Since joining Cornell in 1978, his research has focused on transcriptional regulation, chromatin structure, and RNA polymerase dynamics, supported by grants from the NIH, March of Dimes, and Proctor & Gamble. His work has pioneered techniques like PRO-seq for mapping transcriptional activity.
**Research Interests:** Lis’s lab investigates gene expression control mechanisms, including enhancer/promoter function, transcriptional pausing, and stress responses. Key areas include the role of transcriptional checkpoints (e.g., NELF-Cdk9), epigenetic regulation, and the interplay between chromatin architecture and transcription. Recent studies explore transcriptional memory, viral-host interactions (e.g., SARS-CoV-2), and cancer-related transcriptional dysregulation.
**Awards & Grants:** He is a 2013 Fellow of the American Academy of Arts and Sciences and recipient of the NIH MERIT Award. His lab secured a $33M grant for Academic Integration efforts (2021), advancing collaborative research in computational biology and genomics.
**Advancing Science:** Lis has developed groundbreaking methods like PRO-IP-seq and Femto-Seq to study RNA polymerase modifications and chromatin contacts. His work bridges basic science and translational research, addressing questions in cancer biology, viral pathogenesis, and developmental genetics.
