معرفی
Dr. Charles Danko is an Associate Professor at Cornell University College of Veterinary Medicine, affiliated with the Baker Institute for Animal Health and the Department of Biomedical Sciences. His research bridges computational biology and molecular genetics, focusing on how DNA sequences and chromatin structure regulate gene transcription across species and in diseases like cancer.
Education:
- Postdoctoral Fellow, Genomics/Bioinformatics, Cornell University (2009)
- PhD in Bioinformatics, SUNY Upstate Medical University (2009)
- BS in Biomedical Engineering, Johns Hopkins University (2003)
His work explores the role of gene enhancers in evolution, the transcriptional mechanisms of glioblastoma, and machine learning tools like dREG and dHIT for epigenomic annotation. Recent studies highlight RNA polymerase II dynamics, histone modification prediction, and evolutionary changes in regulatory elements.
Scientific Awards:
- Bausch & Lomb Honorary Science Award (1999)
- Professional and Public Service Award (2008)
- Postdoctoral Fellowships (2009, 2010)
- Best Poster, Reproductive Genomics Retreat (2012)
Danko leads an interdisciplinary lab combining computational and molecular techniques, including PRO-seq, Hi-C, and CRISPR epigenome editing. His team investigates how natural genetic mutations and chromatin packaging influence phenotypic differences and disease states, particularly in CD4+ T cells and glioblastoma.
