معرفی
Franklin Pugh is the Greater Philadelphia Professor of Molecular Biology and Genetics at Cornell University's College of Agriculture and Life Sciences (CALS). He leads the Pugh Lab, focusing on eukaryotic gene regulation mechanisms, including transcription initiation, chromatin remodeling, and epigenomic architecture. His work employs advanced techniques like ChIP-exo, CRISPR/Cas9, and computational tools such as PEGR and STENCIL.
He holds prestigious awards including the AAAS Fellowship and served as Evan Pugh University Professor at Penn State. His research spans yeast and human systems, emphasizing protein-DNA interactions and their roles in disease diagnostics. The lab develops open-source tools for genomic data analysis and collaborates globally on epigenomic projects like the Yeast Epigenome Project (YEP) and Protein Capture Reagent Program (PCRP).
- Education: Ph.D. in Molecular Biology (career history details not explicitly listed in texts).
- Lab Members: Supervises a multidisciplinary team of graduate students, postdocs, and technicians in wet-lab and computational biology.
Research Interests: Molecular mechanisms of gene regulation, transcription machinery assembly, enhancer function, and epigenomic reprogramming under stress. Projects include mapping chromatin architectures and developing diagnostic biomarkers from protein-DNA interaction data.
Publications: Recent work highlights high-resolution epigenomic profiling, computational tool development, and mechanistic insights into transcription initiation. Over 150+ publications spanning molecular biology, genetics, and bioinformatics.
- Awards: Leukemia & Lymphoma Society Fellowships, Searle Scholar, Verne M. Willaman Chair, and leadership roles in academic centers.
Lab Resources: Hosts platforms like PEGR for genomic data management and STENCIL for visualization. Collaborates on initiatives like the PCRP antibody validation program and YEP.
