Irtisha Singh

Dr. Irtisha Singh is an Assistant Professor in the Department of Cell Biology and Genetics at Texas A&M University Health Science Center. She leads the Singh Lab, which integrates computational biology, statistical modeling, and experimental approaches to study transcriptional regulation, RNA processing, and epigenetic mechanisms in cancer. Her work focuses on understanding how dysregulated RNA processing (e.g., intronic polyadenylation) and epigenetic states drive tumorigenesis, particularly in glioblastoma and hematologic malignancies.

Education & Training:

• PhD in Computational Biology and Medicine, Tri-Institutional Program (Cornell University, Weill Cornell Medicine, Memorial Sloan Kettering), 2017
• Postdoctoral Research, Baylor College of Medicine (Molecular and Human Genetics), 2019
• MS in Computational Biology, Carnegie Mellon University, 2009
• B.Tech in Bioinformatics, Vellore Institute of Technology

Research Interests:

• Functional roles of non-coding RNA isoforms (ncp-RNAs) in cellular processes
• Epigenetic drivers of cancer, including super-enhancers in glioblastoma
• Impact of intronic polyadenylation (IPA) dysregulation in leukemia and multiple myeloma
• Computational modeling of chromatin-driven gene expression
• Biomaterials engineering for regenerative medicine and cancer therapy

Key Achievements:

• Discovered that tumor suppressor genes are frequently inactivated via IPA isoforms in CLL and MM
• Identified super-enhancer states as key drivers in glioblastoma stem cells
• Developed computational methods to predict transcriptional regulatory programs
• Recipient of NCI R01, CPRIT Scholar, and Texas A&M seed grants

Collaborations: Collaborates with institutions such as Emory Winship Cancer Institute, Stanford Medicine, Dana-Farber Cancer Institute, and on-campus departments (Biomedical Engineering, Biology).