Chao Cheng

Chao Cheng, Ph.D., serves as Professor at Baylor College of Medicine with triple appointments in the Department of Medicine (Epidemiology and Population Science division), Institute of Clinical and Translational Research, and Dan L Duncan Comprehensive Cancer Center. His research integrates computational methods with cancer biology to decode disease mechanisms through multi-omics data analysis.

Education

• Postdoctoral Training at Yale University (2012)
• PhD from University of Southern California (2007)
• MS from Fudan University (2002)
• BS from East China University of Science and Technology (1999)

Research Focus

Dr. Cheng's work centers on cancer systems biology and precision medicine, developing computational frameworks for:

• Regulatory Networks: Integrating ChIP-seq/RNA-seq data to model transcriptional dysregulation in tumors
• Epigenomic Profiling: Deciphering DNA methylation/histone modification roles in oncogenesis
• Clinical Translation: Predicting immune infiltration, drug responses, and patient outcomes via multi-modal biomarkers

His lab pioneers methods for tumor subtyping and prognostic modeling through combinatorial analysis of genomic, epigenetic, and transcriptomic datasets.

Research Infrastructure

The Cheng Lab operates at the intersection of computational biology and clinical oncology, leveraging Baylor's translational research ecosystem. Key initiatives include cross-species analysis of transcription factor networks, epigenetic drivers of tumor progression, and AI-driven clinical outcome prediction systems integrating somatic mutations with molecular phenotypes.