معرفی
Karen Adelman is the Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. She investigates the interplay between environmental signals and RNA polymerase II transcription, focusing on the molecular mechanisms of gene regulation in development and disease.
Research Overview
Her lab employs genomic approaches in Drosophila and murine models to study Pol II pausing, chromatin structure, and epigenetic features. Key areas include:
- Signal integration for gene network activation
- Transcriptional dynamics in inflammation and cancer
- Paused Pol II-chromatin interplay
- Enhancer RNA transcription
- Stress response gene regulation
Scientific Awards
- National Science Foundation Fellowship (PhD support)
Publications Trends
Her recent work explores:
- Pol II pausing in spermatogenesis
- Integrator complex in stress response
- Notch signaling and elongation control
- Epigenetic RNA methylation dynamics
- Enhancer rewiring in oncogenesis
- Splicing modulator therapeutics
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