جستجوی استاد راهنمای دانشگاهی

Thomas Longden is an Associate Professor in the Department of Physiology at the University of Maryland School of Medicine. He leads a research group focused on neurovascular interactions in health and disease, with particular emphasis on understanding how blood flows through the brain under normal conditions and how this process is disrupted in diseases like Alzheimer's. Dr. Longden received his B.Sc (Hons) and Ph.D. in Pharmacology from the University of Manchester in the UK (2006 and 2010), followed by postdoctoral training at the University of Vermont under Professor Mark Nelson (2011-2015). He was promoted to Assistant Professor at Vermont in 2015 before joining the University of Maryland in February 2019. His research focuses on the control of blood flow in the brain, particularly the mechanisms of neurovascular coupling where neuronal activity triggers changes in blood flow. His lab has made significant discoveries including identifying the brain's capillary network as a 'sensory web' that translates neural activity into vasodilatory electrical signals, and demonstrating how pericytes function as metabolic sentinels that control blood flow through KATP channel-dependent mechanisms. Analysis of Dr. Longden's recent publications reveals a strong focus on pericyte function in neurovascular coupling, electrical signaling in the capillary network, and how these mechanisms are disrupted in Alzheimer's disease and other dementias. His work increasingly incorporates advanced imaging techniques, computational approaches, and innovative tools to study vascular plasticity. 2023: Fellow of the American Physiological Society Cardiovascular Section 2020: NIH Director's New Innovator Award 2017: American Heart Association Scientist Development Grant Multiple travel awards and postdoctoral fellowships Dr. Longden currently mentors several graduate students and postdoctoral fellows in the Longden Lab, which is supported by multiple NIH grants including an NINDS New Innovator Award and an NIA R01 grant. His lab develops and employs advanced techniques including multiphoton microscopy, electrophysiology, optogenetics, and molecular biology to study vascular cells in the brain. The lab is particularly focused on understanding vascular signaling plasticity and how pericytes control brain blood flow in health and Alzheimer's disease.

• Brain blood flow
• Neurovascular coupling
• Functional hyperemia
• +۱۲ مورد دیگر

Hokyung Kay Chung, PhD is an Assistant Professor in the Department of Cell Biology and Physiology at the University of North Carolina at Chapel Hill School of Medicine and a member of the UNC Lineberger Comprehensive Cancer Center. Her research program integrates synthetic biology, immunology, and cancer biology to engineer T cells for enhanced anti-tumor efficacy. Dr. Chung's research focuses on harnessing synthetic biology to reprogram T cell differentiation states for cancer immunotherapy. Her laboratory employs protein engineering, next-generation sequencing, CRISPR screening, and bioinformatics to develop three core platforms: (1) Transcription factor recipes for T cell programming using multiomics atlas-based analysis and in vivo CRISPR screening; (2) Synthetic toolkits for designer immunity including drug-inducible transcription factor circuits and signal rewiring platforms; (3) Hijacking tumors via engineered oncolytic viruses to encode immune modulators. Her work aims to create context-specific cell state programming that enhances T cell therapy efficacy across diverse cancer types. Her publication portfolio demonstrates significant contributions to synthetic immunology, with high-impact papers in Science, Nature Chemical Biology, Cell, and Immunity covering protease-based control systems, T cell differentiation engineering, and tumor microenvironment remodeling. Recent work includes developing sonogenetic CAR-T cells controllable by ultrasound and elucidating metabolic mechanisms of T cell exhaustion. K01 Research Scientist Development Award, NIH, 2023 Keystone Symposia Future of Science Fund Scholarship, 2020 Damon Runyon Fellowship Award, 2019 Salk Women & Science Special Award, 2019 Hans Neurath Outstanding Promise Travel Award, 2017 Dr. Chung leads the Chung Lab at the UNC Lineberger Comprehensive Cancer Center, where she directs research on synthetic T cell engineering. Her lab utilizes advanced techniques including single-cell CRISPR screening, protein engineering, and oncolytic virology to develop next-generation immunotherapies. Current projects focus on creating artificial T cell differentiation pathways and engineering the tumor microenvironment to support persistent anti-tumor immunity.

• Synthetic Biology
• Cancer Immunology
• T Cell Engineering
• +۶ مورد دیگر

Alessio Accardi, Ph.D., is a Professor of Physiology and Biophysics in Anesthesiology at Cornell University. He also holds secondary appointments in the Department of Physiology and Biophysics and Department of Biochemistry. His research focuses on understanding the structural and functional mechanisms of ion channels and transporters, particularly the CLC protein family, which is implicated in human diseases like Bartter’s syndrome. Primary Appointment: Department of Anesthesiology Secondary Appointments: Department of Physiology and Biophysics, Department of Biochemistry Techniques: Cryo-Electron Microscopy, X-ray Crystallography, Electrophysiology His lab uncovers biophysical mechanisms of ion movement across cellular membranes, bridging active and passive transport proteins. Recent work highlights the dual nature of CLC proteins as both ion channels and transporters, challenging previous assumptions. The lab employs a multidisciplinary approach, combining structural biology with functional assays in synthetic lipid bilayers. Their research has direct implications for understanding ion channelopathies and developing targeted therapies. Recent publications explore lipid scrambling mechanisms in TMEM16 proteins, pH-dependent activation in CLC transporters, and voltage-gated channel modulation by anesthetics. These studies utilize Cryo-EM and crystallography to reveal molecular insights. Contacts: ala2022@med.cornell.edu | Accardi Lab Website

• Ion Channels
• Membrane Transporters
• Structural Biology
• +۴ مورد دیگر

Jason P. Breves is a Professor of Biology at Skidmore College , where he investigates the endocrine mechanisms enabling vertebrates to adapt to dynamic environments. His work focuses on pituitary hormones like prolactin and growth hormone in Mozambique tilapia , Atlantic salmon , and other euryhaline fish models to understand how hormonal systems regulate osmoregulation, growth, and stress responses. Education: B.S. in Marine Biology (Roger Williams University), M.S. in Oceanography (University of Rhode Island), Ph.D. in Molecular Biosciences and Bioengineering (University of Hawaii), and Postdoctoral Studies at University of Massachusetts Amherst. Research Interests: The lab explores three major themes: (1) Prolactin signaling in gill, kidney, and gastrointestinal tract; (2) Osmoreception and prolactin gene regulation; and (3) Somatotropic axis modulation by stressors, nutrition, and xenobiotics. His team uses molecular, cellular, and organismal approaches to dissect hormone-gene interactions and their ecological implications. Recent Publications highlight his work on salinity-dependent gene regulation, cortisol's impact on growth hormone pathways, and thermosensitive prolactin cells. Key subfields include ion transporter dynamics , transcriptomic responses to environmental stress , and hormonal crosstalk in osmoregulation . Collaborators span institutions like University of Hawaii, USGS Conte Anadromous Fish Research Center, and University of Gothenburg. Scientific Awards: Grace Evelyn Pickford Medal (2025), New Investigator Award (2019), Gorbman-Bern Award (2019), and multiple Scholander Awards. Students: Mentored over 30 undergraduate researchers, including recipients of conference awards and presentations at Experimental Biology and International Biology of Fish Congress. Funding includes NSF grants (IOS-1755131, DBI-2018952) for molecular targets and advanced instrumentation. His lab serves as a nexus for comparative endocrinology and aquatic physiology research.

• Endocrinology
• Osmoregulation in Fishes
• Molecular Physiology
• +۵ مورد دیگر

Stephen Long is a Professor at the Weill Cornell Graduate School of Medical Sciences, affiliated with the Structural Biology Program at Memorial Sloan Kettering Cancer Center. His research focuses on the molecular mechanisms of ion channels and membrane-embedded enzymes, particularly their roles in calcium signaling, immune function, and cancer. BA in Physics from Amherst College (1994) PhD in Biochemistry from Duke University (2001) Postdoctoral training at Rockefeller University (2007) His lab employs cryo-electron microscopy and X-ray crystallography to study eukaryotic ion channels like Orai, MCU, and BEST1, as well as enzymes such as HHAT and ICMT. Key areas include ion selectivity , channel gating , and therapeutic modulation . Recent work highlights structural transitions in Orai during activation and BEST1’s regulation by GABA. Publications reveal a focus on calcium signaling (Orai, MCU), chloride channel dynamics (BEST1, ASOR), and membrane enzyme mechanisms (HHAT, ICMT). These studies inform drug discovery for immune disorders and cancer. Scientific honors include the Louise and Allston Boyer Young Investigator in Basic Research (2016) Burroughs Wellcome Career Award (2006–2014) His lab mentors graduate students and postdocs, including notable alumni like Melinda Diver (UCSF), George Vaisey (Rockefeller), and Chongyuan Wang (MSKCC). Collaborations span the Tri-Institutional PhD Program in Chemical Biology and Gerstner Sloan Kettering Graduate School.

• Structural Biology
• Ion Channels
• Membrane Proteins
• +۴ مورد دیگر

Stephen B. Long, PhD, is a Member of the Structural Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC), where he directs the Cryo-Electron Microscopy Innovation Laboratory and chairs the Oversight Committee. His research employs structural biology and biophysics to investigate ion channels and membrane-embedded enzymes involved in immune function, vision, cell differentiation, and cancer pathogenesis. Education: BA in Physics, Amherst College (1994) PhD in Biochemistry, Duke University (2001) Postdoctoral training, Rockefeller University (2007) Research Focus: Dr. Long's lab studies atomic-level mechanisms of ion channels (e.g., calcium-activated chloride channels, potassium channels) and enzymes (e.g., RAS methyltransferases, Hedgehog acyltransferase). His work bridges structural insights with therapeutic development for cancer and immune disorders, leveraging cryo-EM and biochemical techniques to reveal fundamental principles of membrane protein function. Publication Trends: Recent articles emphasize cryo-EM structures of ion channels (BEST1, TWIK-2, ASOR) and mitochondrial calcium regulators, with consistent themes in gating mechanisms, drug inhibition, and disease relevance. Interdisciplinary approaches integrate biophysics, pharmacology, and cell biology. Awards: Louise and Allston Boyer Young Investigator Award (2016) Burroughs Wellcome Career Award in Biomedical Sciences (2006–2014) Leadership & Training: Dr. Long mentors graduate students and postdoctoral researchers in the Tri-Institutional Chemical Biology PhD Program and Gerstner Sloan Kettering Graduate School. His lab collaborates extensively with clinical and translational teams at MSKCC.

• Structural Biology
• Biophysics
• Ion Channels
• +۴ مورد دیگر

Stephen B. Long is a Research Professor and Member of the Structural Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC). He holds a PhD from Duke University (2001) and BA from Amherst College (1994), with postdoctoral training at Rockefeller University. His lab combines structural biology techniques (cryo-EM, X-ray crystallography) with biophysics to study eukaryotic membrane proteins, focusing on ion channels (e.g., Orai, MCU, BEST1) and enzymes like ICMT. Key therapeutic areas include cancer, immune disorders, and neurological diseases. Notable achievements include determining structures of CRAC channels and mitochondrial calcium uniporter complexes. He leads the Cryo-Electron Microscopy Innovation Laboratory (CEMIL) and chairs oversight committees for advanced microscopy. Awards include the Boyer Young Investigator Award (2016) and Burroughs Wellcome Career Award (2006-2014). Education: PhD Duke University (2001), BA Amherst College (1994) Labs/Affiliations: Structural Biology Program, CEMIL Director, Sloan Kettering Institute Research emphasizes ion channel mechanisms and membrane enzyme catalysis, with applications to cancer therapy and disease modeling. The lab actively trains graduate students and postdocs in structural biology and electrophysiology techniques.

• Structural Biology
• Membrane Protein Mechanisms
• Ion Channel Physiology
• +۵ مورد دیگر

Laura Bianchi, Ph.D., is a Professor of Physiology and Biophysics with expertise in ion channel biology and sensory neuroscience. Her research focuses on glial-neuronal interactions, particularly the role of ion channels and transporters in modulating synaptic function and behavior using C. elegans as a model organism. Key interests include DEG/ENaC channels in sensory perception and neurotoxicity, and the molecular mechanisms underlying glial contributions to nervous system function. Education: She holds a PhD in Physiology from the University of Florence (1997) and a BS in Biochemistry from the University of Milan (1992). Research Highlights: Bianchi's lab investigates glial ion channel regulation of GABA release, calcium-mediated neurotoxicity in DEG/ENaC dysfunction, and the discovery of novel glial-enriched channels. Recent work includes identifying an ER anion channel and developing protocols for imaging calcium in glia. Notable Awards: U-Choose SEEDS Award (2024), FASI Award (2024) Labs/Teams: Active in collaborative research on mechanosensation and neurodegeneration, with a lab website at laura-bianchi.com .

• Ion Channels
• Neuroscience
• Glial Physiology
• +۳ مورد دیگر

Cristina Batista Paulino is an Associate Professor and Head of the cryo-EM unit at the University of Groningen's Faculty of Science and Engineering. She leads the Enzymology group within the Groningen Biomolecular Sciences and Biotechnology department. Her research focuses on structural biology, particularly membrane proteins and cryo-electron microscopy, elucidating transport mechanisms in membrane proteins. Education: PhD in Biophysics (2014, Max-Planck Institute under Prof. Werner Kühlbrandt), postdoc at the University of Zurich (Prof. Raimund Dutzler). Joined the University of Groningen as an Assistant Professor in 2017, promoted to Associate Professor thereafter. Research Interests: Structural-functional studies of membrane transporters and channels, cryo-EM applications in membrane biology, and protein-lipid interactions. Key projects include understanding the structure-function relationship in ABC transporters and ion channels. Grants & Awards: ENW-KLEIN grant (2021, €700k) for OpuA transporter research, NVBMB Prize 2020, Marie Skłodowska-Curie Fellowship (2017). Labs/Teams: Heads the cryo-EM facility, collaborates with the Electron Microscopy Group and Membrane Enzymology Group.

• Structural Biology
• Cryo-Electron Microscopy
• Membrane Proteins
• +۳ مورد دیگر

Stephen Brohawn is an Associate Professor in the Department of Molecular and Cell Biology at the University of California, Berkeley's College of Chemistry. His research focuses on the molecular mechanisms of ion channels and transporters involved in cellular electrical signaling, with particular emphasis on mechanosensation and sensory transduction. His laboratory employs an integrated approach combining structural biology (cryo-EM and X-ray crystallography), electrophysiology, biophysics, and biochemistry to investigate how membrane proteins convert physical forces into cellular signals. Current research centers on force sensation mechanisms, particularly the molecular basis of touch, hearing, and pain transduction through ion channels like Piezo, TRP, and K2P families. Analysis of recent publications reveals consistent focus on mechanosensitive channels (especially TRAAK), structural characterization of viral proteins (SARS-CoV-2), and development of optogenetic tools. His work demonstrates strong interdisciplinary integration of structural data with functional validation. NIH Director's New Innovator Award (2016) Sloan Research Fellowship (2020) NYSCF-Robertson Neuroscience Investigator (2017) McKnight Scholar Award (2017) Klingenstein-Simons Fellowship (2016) Brohawn mentors numerous graduate students and postdocs, with trainees securing prestigious fellowships including NIH F32 awards. His lab has received significant funding from NIH, Fast Grants, and the Rennie Fund for Epilepsy. Current research directions include developing novel tools for sensory transduction studies and investigating lipid-protein interactions in channel gating.

• Ion Channel Biophysics
• Mechanosensation
• Structural Biology
• +۶ مورد دیگر

Karen Hannigan, Ph.D., serves as a Research Assistant Professor in the Department of Pharmacology at the University of Nevada, Reno School of Medicine, where her research centers on calcium signaling mechanisms in smooth muscle and cardiac cells and their implications for cardiovascular and gastrointestinal diseases. Her academic credentials include: B.S. in Anatomy from Queen's University Belfast, Northern Ireland Ph.D. in Physiology from Dundalk Institute of Technology, Ireland Dr. Hannigan's research program investigates dysregulation of Ca 2+ signaling in smooth muscle pathophysiology, with particular emphasis on gastrointestinal sphincters (internal anal sphincter and lower esophageal sphincter) and urogenital tissues (corpus cavernosum). Her work integrates cellular electrophysiology, calcium imaging, and pharmacological approaches to study ion channels—including BK Ca and Ano1—and their roles in muscle tone generation, pacemaker activity, and neuromuscular transmission across multiple species (mouse, monkey, rabbit). Analysis of her 15 most recent publications (2010–2020) reveals a cohesive research trajectory focused on smooth muscle physiology, with 60% of articles published between 2016–2020. Key thematic clusters include: (1) interstitial cells of Cajal as pacemakers in gastrointestinal motility, (2) β-adrenergic regulation of calcium channel dynamics in cardiac tissue, and (3) pharmacological modulation of BK Ca channels in erectile physiology. Her methodological rigor spans super-resolution imaging, comparative animal models, and translational investigations of motility disorders. No major scientific awards were documented in the source materials. Information regarding student mentorship, grant funding, or laboratory leadership was not provided in the available documentation. Research infrastructure details including laboratory facilities, collaborative teams, or ongoing projects were not specified in the source texts.

• Calcium Signaling
• Smooth Muscle Physiology
• Cardiovascular Disease
• +۳ مورد دیگر

Dr. Ira Kurtz is a Professor of Medicine at the University of California, Los Angeles (UCLA), and Chief of Nephrology. He is also a Member of the Brain Research Institute. His research focuses on renal physiology, acid-base homeostasis, and molecular transport mechanisms, particularly within the SLC4 transporter family. His work spans structural biology, molecular dynamics, and clinical nephrology. His scientific contributions include structural characterization of SLC4 transporters using cryo-EM and molecular dynamics simulations, revealing key insights into ion translocation pathways and conformational dynamics. He has extensively studied the molecular basis of proximal renal tubular acidosis and electrolyte disorders, with particular emphasis on NBCe1 transporter function and regulation. Dr. Kurtz's publications demonstrate expertise in renal acid-base physiology, membrane transporter characterization, and clinical applications. His work connects fundamental molecular mechanisms with human diseases, including corneal endothelial dystrophies, thrombotic microangiopathy from anti-VEGF treatments, and genetic disorders affecting ion transport. His research methodology integrates computational biology, structural biology, and translational medicine approaches. He has developed novel quantitative models for acid-base analysis and electrolyte disorders, challenging established paradigms like the Stewart approach through critical evaluation of bicarbonate-centered models.

• Renal Physiology
• Acid-Base Homeostasis
• Molecular Transport Mechanisms
• +۳ مورد دیگر

Fiona Britton is Chair and Professor of Biomedical Sciences in the School of Dental Medicine at the University of Nevada, Las Vegas (UNLV). Holding a B.Sc. and Ph.D. from Ulster University, Northern Ireland, she has built an internationally recognized research program focused on ion-channel physiology, smooth-muscle excitability, and cardiovascular regulation. Education Ph.D., Ulster University, Northern Ireland B.Sc., Ulster University, Northern Ireland Research Focus Professor Britton’s work centers on the molecular and functional characterisation of calcium-activated chloride channels (CaCCs), bestrophins, anoctamins/TMEM16, TRPV channels, and voltage-gated calcium channels. Using patch-clamp electrophysiology, molecular biology, and transgenic models, her group investigates how these channels control arterial tone, cardiac pacemaking, gastrointestinal motility, and uterine blood flow. A recurring theme is the integration of ion-channel activity with intracellular Ca²⁺ handling, offering insights into hypertension, heart failure, and pregnancy-related vascular adaptation. Across more than 40 peer-reviewed publications spanning 1997-2021, her studies trace an arc from cloning and expression of cardiac chloride channels (ClC-2, ClC-3, bestrophins) to demonstrating their physiological impact in smooth-muscle organs. Recent work has illuminated β-adrenoceptor subtype pharmacology in cremaster arterioles and TRPV3-mediated vasodilation in uterine vasculature, underscoring translational relevance to reproductive and cardiovascular medicine. Contact Email: fiona.britton@unlv.edu Phone: 702-774-8680 Mail Code: 7412, University of Nevada, Las Vegas

• Ion-channel physiology
• Cardiovascular electrophysiology
• Smooth-muscle excitability
• +۴ مورد دیگر

Dr. Zui Pan is a Professor at The University of Texas at Arlington (UTA) in the College of Nursing and Health Innovation, with additional appointments in the Department of Biology, Bioengineering, and Kinesiology. She has been at UTA since 2016, initially as an Associate Professor and promoted to Professor in 2021. Prior to UTA, she held academic positions at The Ohio State University, Rutgers-Robert Wood Johnson Medical School, and UMDNJ. Dr. Pan earned her BS and MS in Biophysics from Nankai University in China, followed by a PhD in Biophysics from the Institute of Biophysics at the Chinese Academy of Sciences. She completed postdoctoral training in the Department of Physiology and Biophysics at Case Western Reserve University. Dr. Pan's research focuses on calcium and zinc signaling in esophageal cancer, muscle, and heart diseases. Her work aims to understand the cellular mechanisms underlying dysregulated calcium signals to provide insights for disease prevention and treatment. She has published over 100 articles in prestigious journals including Nature, Nature Cell Biology, and Nature Communications, with research featured in Newsweek, Reader's Digest, and ScienceDaily. Analysis of Dr. Pan's recent publications reveals a strong focus on calcium signaling pathways in cancer biology, particularly esophageal cancer. Her work integrates molecular biology, physiology, and mathematical modeling to understand store-operated calcium entry mechanisms and their role in cancer progression. Recent publications also show expanding interests in cardiac physiology, tissue engineering, and translational applications of her basic research findings. Dean's Research Mentoring Award, UTA College of Nursing and Health Innovation (2024) Faculty Scholarship Mentor Award, UTA College of Nursing and Health Innovation (2024) Interdisciplinary Research Award, UTA (2024) R15 Research Award, National Institutes of Health (2023) Senior Member, National Academy of Inventors (2020) Texas STARS Award (2016) Dr. Pan has mentored numerous students across multiple disciplines, serving as Dissertation Committee Chair for PhD students in Nursing, Kinesiology, and related programs. Her laboratory has received over $3 million in research funding from NIH (R01, R15, S10 awards), the American Diabetes Association, and other sources. She actively collaborates with researchers across multiple departments and institutions. Dr. Pan directs a research laboratory focused on calcium signaling mechanisms, with specialized equipment including a Confocal Microscopy and Cell Imaging Core. Her team includes postdoctoral researchers, graduate students, and undergraduate researchers working collaboratively on projects spanning cancer biology, cardiac physiology, and muscle regeneration.

• Calcium signaling
• Zinc signaling
• Esophageal cancer
• +۶ مورد دیگر

Katherine L. Perkins, PhD is an Associate Professor in the Department of Physiology and Pharmacology at SUNY Downstate Medical Center, focusing on neurophysiology and epilepsy research . Her work investigates GABAergic signaling , interneuron networks , and extracellular space dynamics in seizure mechanisms. Research Themes: Depolarizing GABA responses in hippocampal neurons Interneuron network activation patterns Role of extracellular matrix in epilepsy Pharmacological modulation of seizure activity Key Techniques: Cell-attached and whole-cell patch-clamp recording, rodent brain slice models, synaptic current analysis. Her publications span Journal of Neurophysiology , Epilepsy Research , and Journal of Neuroscience , with a focus on synaptic transmission and neuronal excitability in epilepsy models. Collaborations: Sabina Hrabetova's lab (extracellular space studies)

• Neurophysiology
• Epileptogenesis
• GABAergic Signaling
• +۴ مورد دیگر