Ira Kurtz

Dr. Ira Kurtz is a Professor of Medicine at the University of California, Los Angeles (UCLA), and Chief of Nephrology. He is also a Member of the Brain Research Institute. His research focuses on renal physiology, acid-base homeostasis, and molecular transport mechanisms, particularly within the SLC4 transporter family. His work spans structural biology, molecular dynamics, and clinical nephrology.

His scientific contributions include structural characterization of SLC4 transporters using cryo-EM and molecular dynamics simulations, revealing key insights into ion translocation pathways and conformational dynamics. He has extensively studied the molecular basis of proximal renal tubular acidosis and electrolyte disorders, with particular emphasis on NBCe1 transporter function and regulation.

Dr. Kurtz's publications demonstrate expertise in renal acid-base physiology, membrane transporter characterization, and clinical applications. His work connects fundamental molecular mechanisms with human diseases, including corneal endothelial dystrophies, thrombotic microangiopathy from anti-VEGF treatments, and genetic disorders affecting ion transport.

His research methodology integrates computational biology, structural biology, and translational medicine approaches. He has developed novel quantitative models for acid-base analysis and electrolyte disorders, challenging established paradigms like the Stewart approach through critical evaluation of bicarbonate-centered models.