Stephen Long

Stephen B. Long is a Research Professor and Member of the Structural Biology Program at Memorial Sloan Kettering Cancer Center (MSKCC). He holds a PhD from Duke University (2001) and BA from Amherst College (1994), with postdoctoral training at Rockefeller University. His lab combines structural biology techniques (cryo-EM, X-ray crystallography) with biophysics to study eukaryotic membrane proteins, focusing on ion channels (e.g., Orai, MCU, BEST1) and enzymes like ICMT. Key therapeutic areas include cancer, immune disorders, and neurological diseases. Notable achievements include determining structures of CRAC channels and mitochondrial calcium uniporter complexes. He leads the Cryo-Electron Microscopy Innovation Laboratory (CEMIL) and chairs oversight committees for advanced microscopy. Awards include the Boyer Young Investigator Award (2016) and Burroughs Wellcome Career Award (2006-2014).

• Education: PhD Duke University (2001), BA Amherst College (1994)
• Labs/Affiliations: Structural Biology Program, CEMIL Director, Sloan Kettering Institute

Research emphasizes ion channel mechanisms and membrane enzyme catalysis, with applications to cancer therapy and disease modeling. The lab actively trains graduate students and postdocs in structural biology and electrophysiology techniques.