معرفی
Stephen Long is a Professor at the Weill Cornell Graduate School of Medical Sciences, affiliated with the Structural Biology Program at Memorial Sloan Kettering Cancer Center. His research focuses on the molecular mechanisms of ion channels and membrane-embedded enzymes, particularly their roles in calcium signaling, immune function, and cancer.
- BA in Physics from Amherst College (1994)
- PhD in Biochemistry from Duke University (2001)
- Postdoctoral training at Rockefeller University (2007)
His lab employs cryo-electron microscopy and X-ray crystallography to study eukaryotic ion channels like Orai, MCU, and BEST1, as well as enzymes such as HHAT and ICMT. Key areas include ion selectivity, channel gating, and therapeutic modulation. Recent work highlights structural transitions in Orai during activation and BEST1’s regulation by GABA.
Publications reveal a focus on calcium signaling (Orai, MCU), chloride channel dynamics (BEST1, ASOR), and membrane enzyme mechanisms (HHAT, ICMT). These studies inform drug discovery for immune disorders and cancer.
Scientific honors include the
- Louise and Allston Boyer Young Investigator in Basic Research (2016)
- Burroughs Wellcome Career Award (2006–2014)
His lab mentors graduate students and postdocs, including notable alumni like Melinda Diver (UCSF), George Vaisey (Rockefeller), and Chongyuan Wang (MSKCC). Collaborations span the Tri-Institutional PhD Program in Chemical Biology and Gerstner Sloan Kettering Graduate School.
