معرفی
Derek S. Tan is a tenured Professor and Chair of the Chemical Biology Program at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (MSK). He also holds the Eugene W. Kettering Chair and is a Tri-Institutional Professor at Weill Cornell Medicine and The Rockefeller University. He directs the Tri-Institutional PhD Program in Chemical Biology since 2012.
- Education:
- BS in Chemistry from Stanford University (1995)
- PhD in Chemistry from Harvard University (2000)
Tan's research focuses on diversity-oriented synthesis and rational drug design to develop chemical probes for cancer and infectious disease research. His work leverages natural product insights to address challenges in small-molecule discovery, including antibiotic development for Mycobacterium tuberculosis and Yersinia pestis, and novel methodologies for synthesizing complex molecular architectures.
The lab's 15 most recent publications highlight advancements in chemical biology methodologies (e.g., ubiquitin probes, adenylation enzyme inhibitors), antibiotic development (targeting Gram-negative bacteria, tuberculosis), and structural innovations in macrocycle synthesis. These works reflect interdisciplinary collaborations and translational applications in both oncology and microbiology.
Scientific Awards:
- Louise and Allston Boyer Young Investigator Award (2010)
- Dean's Award for Excellence in Teaching (2013)
As an advisor, Tan has mentored over 30 graduate students, postdoctoral fellows, and research assistants in his lab. His Tri-Institutional Program fosters multidisciplinary training, while his lab affiliations span the Center for Experimental Therapeutics and Gerstner Sloan Kettering Graduate School.
Labs & Collaborations:
- Sloan Kettering Institute Chemical Biology Program
- Tri-Institutional PhD Program in Chemical Biology
- Collaborations with Luis Quadri (Cornell), Paul Hergenrother, and others
