معرفی
Dr. Daniel Bachovchin is a Professor and Geoffrey Beene Junior Faculty Chair at Memorial Sloan Kettering Cancer Center's Sloan Kettering Institute, leading the Chemical Biology Program. He holds faculty roles at Weill Cornell Medical College, Rockefeller University, and Gerstner Sloan Kettering Graduate School. His research focuses on enzyme functions in cancer and immunity, particularly serine proteases' roles in inflammasome activation. He earned his PhD from The Scripps Research Institute and AB from Harvard University.
- Expertise: Innate immunity, inflammasome biology, protease inhibition, chemical probes
- Affiliations: Tri-Institutional Chemical Biology Program, Pharmacology training programs
Key research themes include NLRP1 and CARD8 inflammasome mechanisms, redox signaling, and pyroptosis pathways. His lab develops small molecule inhibitors and activity-based probes to study these systems.
Recent work highlights include discovering DPP8/9 inhibitors as pyroptosis inducers in cancer and uncovering redox stress sensing by inflammasomes. Over 90 peer-reviewed publications span high-impact journals like Science, Nature, and Cell.
Awarded multiple grants including Pershing Square Sohn Prize, Sloan Fellowship, and teaching awards. Mentors over 20 trainees, including PhD students and postdocs in chemical biology and immunology.
