معرفی
Alessio Accardi, Ph.D., is a Professor of Physiology and Biophysics in Anesthesiology at Cornell University. He also holds secondary appointments in the Department of Physiology and Biophysics and Department of Biochemistry. His research focuses on understanding the structural and functional mechanisms of ion channels and transporters, particularly the CLC protein family, which is implicated in human diseases like Bartter’s syndrome.
- Primary Appointment: Department of Anesthesiology
- Secondary Appointments: Department of Physiology and Biophysics, Department of Biochemistry
- Techniques: Cryo-Electron Microscopy, X-ray Crystallography, Electrophysiology
His lab uncovers biophysical mechanisms of ion movement across cellular membranes, bridging active and passive transport proteins. Recent work highlights the dual nature of CLC proteins as both ion channels and transporters, challenging previous assumptions.
The lab employs a multidisciplinary approach, combining structural biology with functional assays in synthetic lipid bilayers. Their research has direct implications for understanding ion channelopathies and developing targeted therapies.
Recent publications explore lipid scrambling mechanisms in TMEM16 proteins, pH-dependent activation in CLC transporters, and voltage-gated channel modulation by anesthetics. These studies utilize Cryo-EM and crystallography to reveal molecular insights.
Contacts: ala2022@med.cornell.edu | Accardi Lab Website
