جست‌وجوی استاد و پژوهشگر

Dawei Dongمشاهده پروفایل

استاد پژوهشی

• bioinformatics
• computational biology
• evolution
• +۱ مورد دیگر

Dawei Dong, PhD, is a Research Professor specializing in Animal Biology. His work bridges computational and experimental approaches, with core research interests in bioinformatics, computational biology, evolutionary mechanisms, and genomics. Though institutional affiliations are unspecified in available sources, his publication record demonstrates leadership in interdisciplinary life science research. Dr. Dong's research integrates molecular biology, neuroscience, and disease mechanisms, with emphases on: Cytoskeletal dynamics (e.g., actin isoform functions in retinal physiology and cell migration) Post-translational modifications (particularly protein arginylation in neurodegeneration and signaling) Disease pathogenesis (including cancer metabolism and chronic wasting disease biomarkers) Evolutionary conservation of protein function Analysis of his 15 most recent publications (2018–2024) reveals dominant themes in cellular structure/function, neural processing, and molecular pathology. Over 60% focus on actin biology or arginylation pathways, primarily using knockout models and omics techniques. Earlier foundational work in visual processing and neural networks informs his current methodology.

Nancy A. Speckمشاهده پروفایل

استاد

• Hematopoietic stem cells
• Leukemia
• Core binding factors
• +۶ مورد دیگر

Nancy A. Speck is the John W. Eckman Professor in Medical Science at the Perelman School of Medicine, University of Pennsylvania . She serves as an Investigator at the Abramson Family Cancer Research Institute, a Member of the Abramson Cancer Center and Institute for Regenerative Medicine, and Co-Leader of the Hematologic Malignancies Program at the Abramson Cancer Center. Education : B.A. from Western Maryland College (1977), Ph.D. from Northwestern University (1983) Her research focuses on hematopoietic stem cell (HSC) formation during embryonic development, specifically the role of Runx1-CBFβ in hemogenic endothelium specification and HSC emergence. Her lab investigates how Runx1 mutations contribute to pre-leukemic stem cell formation and leukemia progression, and explores the intersection of inflammatory signaling and ribosome biogenesis in HSC regulation. Recent studies highlight chromatin accessibility , transcriptional networks , and functional heterogeneity of hemogenic endothelium. Publications span leukemia biology , HSC developmental trajectories , and inflammatory modulation in hematopoiesis. Scientific Awards : National Academy of Sciences (2025), ISEH Donald Metcalf Award (2018) Speck's lab has trained numerous researchers and collaborates with institutions like the Abramson Cancer Center and Salk Institute. Her work has been cited in journals such as Nature , Genes & Development , and Blood , with ongoing investigations into inherited leukemia predisposition and pre-HSC biology .

David Michael Allmanمشاهده پروفایل

استاد

• Plasma Cell Differentiation
• B Cell Development
• Immunology
• +۵ مورد دیگر

David Michael Allman is a Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania , where he also serves as Vice Chair for Faculty Development and Academic Affairs. His research focuses on B cell lineage differentiation, plasma cell survival mechanisms, and immunoregulatory networks. Education: BS in Microbiology (1982, Pennsylvania State University), PhD in Immunology (1993, University of Pennsylvania) Postgraduate Training: I.R.T.A. Fellow (NIH), Fox Chase Cancer Center Fellow (1996-99) Research Themes include: Plasma Cell Longevity: Analyzing survival niches in bone marrow and gut mucosa, molecular pathways (e.g., mTORC1, unfolded protein response) B Cell Fate Regulation: Exploring transcription factors like EBF and YY1 in lineage commitment Vaccine Immunology: Developing lipid nanoparticle mRNA vaccines (e.g., Lyme disease) and understanding IgA-mediated mucosal-systemic immune links Scientific Contributions span 30+ years, with key awards including the Edward David Lustbader Prize (1999), Leukemia and Lymphoma Society Scholar (2004-09), and multiple teaching accolades. His PubMed profile highlights recent work on neuroinflammation, sepsis, and transcriptional networks.

Stefan Muljoمشاهده پروفایل

استاد

• RNA Biology
• Immunology
• Hematopoiesis
• +۵ مورد دیگر

Dr. Stefan Muljo serves as Chief of the Integrative Immunobiology Section within the Laboratory of Immune System Biology at the National Institutes of Health (NIH). Appointed as a tenure-track investigator in 2008 and promoted to tenured Senior Investigator in 2016, he leads a research program focused on understanding post-transcriptional regulation of immune system development. His section is part of NIAID's Division of Intramural Research located at the NIH Main Campus in Bethesda, MD. Dr. Muljo earned his Ph.D. from The Johns Hopkins University School of Medicine, with dissertation work partially conducted at UC Berkeley. Following a postdoctoral fellowship at Harvard Medical School's Immune Disease Institute, he joined NIAID in 2008. He currently serves as faculty for the NIH-OxCam and NIH-Penn graduate partnership programs, mentoring the next generation of immunologists and RNA biologists. His research centers on RNA biology within the immune system, specifically investigating how gene expression programs are regulated post-transcriptionally through RNA-binding proteins, long non-coding RNAs, and microRNAs. Key research areas include hematopoietic stem cell differentiation, fetal versus adult hematopoiesis, regulation of human endogenous retroviruses, and the function of innate-like B-1 cells. His work has identified important molecular players like Lin28b as lineage-determining factors for fetal hematopoietic stem cells, with significant implications for regenerative medicine. Analysis of Dr. Muljo's publication record reveals consistent contributions to understanding post-transcriptional regulation in immunology, with recent work focusing on RNA-binding proteins like MATRIN3 and RBM4, macrophage polarization in allergy, and B lymphocyte development. His research spans fundamental mechanisms of gene regulation to potential therapeutic applications, particularly in manipulating microRNAs for immune modulation. Dr. Muljo actively participates in training through the NIH-OxCam Partnership Program, offering joint doctoral studentships to study fetal hematopoiesis in both mouse models and human systems. His laboratory employs an integrative systems biology approach combining genome-wide measurements with experimental perturbations to reverse engineer molecular logic of cellular differentiation. His laboratory maintains an active research program investigating how post-transcriptional regulation contributes to immune system development and function, with particular interest in translating basic discoveries to improve human health, especially for conditions like sickle cell disease and beta-thalassemia. The section's work on fetal hemoglobin production has led to a pending patent application with potential therapeutic applications.

Alison M Michieمشاهده پروفایل

استاد

• Molecular Lymphopoiesis
• Haematopoietic Stem Cells
• B-cell Development
• +۶ مورد دیگر

Alison M. Michie is a Professor in Molecular Lymphopoiesis at the Paul O'Gorman Leukaemia Research Centre, University of Glasgow. She leads a research group focused on molecular mechanisms of hematopoietic stem cell differentiation into B/T lymphocytes and the pathogenesis of chronic lymphocytic leukemia (CLL). Her work bridges fundamental biology and translational applications, with collaborations across academia (e.g., University of Leicester, University of Edinburgh) and industry (GlaxoSmithKline). Her research interests center on: Molecular events in early B/T cell development PKC and mTOR signaling in leukemia Oncogenic triggers for CLL Therapeutic targeting of leukemic stem cells Microenvironmental influences on cancer cell survival Her recent publications (2019–2025) demonstrate a strong focus on kinase signaling (PKC, mTOR), metabolic reprogramming in leukemia, and epigenetic regulation. Trends include targeting quiescent stem cells, exploiting metabolic vulnerabilities, and developing precision therapies for CLL/AML. Grants include: Medical Research Council (2023–2026): eEF2K/eEF2 signalling in leukemia Blood Cancer UK (2019–2021): FOXO regulation in CLL Kay Kendall Leukaemia Fund (2014–2018): mTOR in CLL She directs the Molecular Lymphopoiesis group and collaborates internationally to validate therapeutic targets and model leukemia progression.

Gerald Crabtreeمشاهده پروفایل

استاد

• Chromatin Regulation
• Epigenetics
• Developmental Biology
• +۷ مورد دیگر

Gerald Crabtree is the David Korn, MD, Professor of Pathology and Professor of Developmental Biology at Stanford University School of Medicine. He is a member of multiple interdisciplinary institutes, including Bio-X, the Cardiovascular Institute, SPARK at Stanford, and the Stanford Cancer Institute. His research bridges chromatin biology, cancer, neurodevelopment, and synthetic biology, with a focus on ATP-dependent chromatin remodeling complexes such as BAF (mSWI/SNF). His laboratory investigates how mutations in chromatin regulators contribute to cancer and neurodevelopmental disorders. He has pioneered methods using synthetic ligands to control gene function and chromatin dynamics. His work has revealed that chromatin remodeling complexes are highly dosage-sensitive and context-specific, with unique neural assemblies playing critical roles in brain development. Dr. Crabtree's recent publications focus on: Minute-scale changes in BAF complex composition in response to synaptic activity Chemical-induced proximity strategies to reactivate tumor suppressor genes in lymphoma Chromatin priming in T cell development Transdiagnostic metabolic endophenotypes in neuropsychiatric disorders His honors include: Member of the National Academy of Sciences (1997) HHMI Investigator (1988–2021) NIH Javits Neuroscience Investigator Award (2013) Stanford Faculty Mentor of the Year (2008) Fellow of the American Association for the Advancement of Science (2015) He actively mentors postdoctoral fellows and doctoral students, serving as advisor to Samuel Kim and sponsor to Moritz Classen, Sabin Nettles, and Yanlan Wang. He teaches in multiple graduate programs, including Cancer Biology, Developmental Biology, Immunology, and Chemical and Systems Biology. His lab, accessible at www.crablab.com , continues to explore fundamental mechanisms of chromatin regulation with therapeutic implications.

Dyan Morganمشاهده پروفایل

استاد آموزشی

• Biology Education
• Developmental Biology
• Immunology
• +۳ مورد دیگر

Dyan Morgan is an Associate Teaching Professor in the Department of Biology at the University of Kansas, specializing in STEM education and developmental biology research. Their work bridges pedagogical innovation with molecular mechanisms in model organisms. Role: Faculty Fellow and Teaching Professor University: University of Kansas Department: Biology Email: dyan.morgan@ku.edu Morgan focuses on improving higher-order cognitive skill development in biology education through tools like metacognitive mapping, TED Talks integration, and Zotero-based mentoring. Their research also explores cellular and immunological processes using C. elegans and bacterial models. Recent publications highlight hybrid laboratory curricula, online immunology labs, and developmental gene regulation. Key themes include educational technology adaptation, inquiry-based learning, and elucidating molecular pathways in stem cell differentiation.

• Chronic Lymphocytic Leukemia (CLL)
• B-cell Malignancies
• RUNX Protein Oncogenesis
• +۴ مورد دیگر

Dr. Jodie Hay is a Research Fellow at the University of Glasgow's Paul O'Gorman Leukaemia Research Centre within the Institute of Cancer Sciences (College of Medical, Veterinary & Life Sciences). Based at Gartnavel General Hospital in Glasgow, her research bridges molecular oncology and translational hematology with significant contributions to chronic lymphocytic leukemia (CLL) pathogenesis. Her primary research interests include: B-cell receptor (BCR) signaling pathways in leukemia RUNX protein-mediated oncogenesis mTORC1 signaling in disease progression Hematopoietic stem cell microenvironment engineering CLL tumor microenvironment interactions Recent work demonstrates a shift toward SARS-CoV-2 epidemiology during 2020-2021, with multiple high-impact publications in Nature Communications and The Lancet, before refocusing on cancer research in 2022-2024. Current funding includes a Tenovus Scotland grant (2022-2024) investigating BCR signaling effects on the CCR4/CCL22 axis in the CLL microenvironment. The lab maintains strong clinical connections through Gartnavel General Hospital and collaborates extensively with immunologists, bioengineers, and epidemiologists. Technical expertise centers on: Subcellular fractionation of primary leukemia cells Nuclear/cytoplasmic protein trafficking analysis BCR pathway characterization Stem cell niche modeling

Robert Schwartzمشاهده پروفایل

استادیار

• Liver Disease
• Viral Hepatitis
• Non-Alcoholic Fatty Liver Disease
• +۶ مورد دیگر

Dr. Robert Schwartz serves as an Assistant Professor of Medicine at the Sanford I. Weill Medical College of Cornell University and practices as an Attending Physician at New York-Presbyterian Hospital Cornell campus. A native New Yorker, he obtained his B.E. in Chemical Engineering from Cooper Union and both his M.D. and Ph.D. in Biomedical Engineering from the University of Minnesota. Following Internal Medicine residency at Barnes-Jewish Hospital at Washington University and fellowship training in Gastroenterology and Hepatology at Brigham and Women's Hospital, he established the Schwartz Lab at the Belfer Research Building in January 2014. Dr. Schwartz's research program centers on developing innovative in vitro models of human liver disease through interdisciplinary approaches combining stem cell biology, hepatocyte biology, and engineering techniques. His laboratory investigates multiple facets of liver pathophysiology including: Viral hepatitis mechanisms and therapeutic interventions Autoimmune and metabolic causes of liver disease including NAFLD Stem cell-derived hepatocyte models for disease modeling Organoid platforms for viral infection studies Host-virus interactions in SARS-CoV-2 and hepatitis viruses Cellular mechanisms of liver fibrosis and regeneration Analysis of Dr. Schwartz's extensive publication record reveals a strategic focus on leveraging cutting-edge technologies to model and understand viral pathogenesis in the liver. His work has made significant contributions to understanding SARS-CoV-2 infection mechanisms through multi-organoid platforms, with particular emphasis on identifying host factors critical for viral replication. His research group has developed advanced stem cell-based models that preserve inter-individual differences in drug metabolism while enabling detailed study of viral life cycles. As a dedicated mentor, Dr. Schwartz has guided numerous students through research experiences in his laboratory, with many of his trainees progressing to medical school and advanced research careers. The Schwartz Lab operates within the state-of-the-art facilities of the Belfer Research Building, featuring a BSL-2 Cell and Tissue Culture Lab, access to microscopy cores, an in-house fabrication facility, and shared flow cytometry equipment. The laboratory actively participates in the Jill Roberts Institute for Research in Inflammatory Bowel Disease Research In Progress Seminar series and maintains its own Journal Club to foster scientific discourse among team members.

Jane Yuanمشاهده پروفایل

دانشیار بالینی

• Hematopathology
• Lymphoproliferative Disorders
• Lymphoma
• +۳ مورد دیگر

Jane Yuan, M.D., Ph.D. is a Clinical Associate Professor in the Department of Laboratory Medicine and Pathology at Mayo Clinic's Alix School of Medicine in Jacksonville, Florida. Her clinical expertise focuses on the diagnosis of lymphoproliferative disorders, with extensive research in hematopathology and molecular diagnostics of hematologic malignancies. Dr. Yuan completed her Hematopathology fellowship at the University of Nebraska Medical Center in 2013 and her residency in Anatomic and Clinical Pathology at Georgia Regents University in 2011. She is board certified in both Anatomic & Clinical Pathology (2012) and Hematopathology (2024) by the American Board of Pathology, demonstrating her comprehensive expertise in general and specialized pathology. Her research spans lymphoma, leukemia, and molecular pathology with particular emphasis on mantle cell lymphoma, acute leukemias with specific genetic mutations, and plasmablastic lymphoma. Analysis of her publication record shows consistent contributions to understanding the genomic landscape of hematologic malignancies and developing improved diagnostic approaches. 1st Place, 1st Annual Chili for Change: Supporting Veterans DLMP-MCS EID Committee (2023) Dr. Yuan holds leadership positions in multiple professional organizations including serving as Leadership Committee Member of the Chinese American Pathologists Association (2023-present), Abstract Review Board Member for the United States and Canadian Academy of Pathology (2022-present), and active participation in Mayo Clinic's Lymphoma Working Group and Myeloid Working Group. Her commitment to equity and inclusion is demonstrated through her service on the DLMP-MCS Equity, Inclusion and Diversity Committee as both Executive Committee Member and Subcommittee Lead (2022-2024).

• Childhood Leukaemia
• Infant Acute Lymphoblastic Leukaemia (ALL)
• Prenatal B Lymphopoiesis
• +۷ مورد دیگر

Anindita Roy is a Professor of Paediatric Haematology at the University of Oxford , affiliated with the Department of Paediatrics and Childhood Leukaemia Research Group . She works closely with Prof Irene Roberts and serves as an Honorary Paediatric Haematology Consultant at Great Ormond Street Hospital . Education: MBBS and Paediatric training, Christian Medical College Vellore, India PhD, Imperial College London Her research focuses on prenatal B lymphopoiesis and childhood leukemia origins, particularly infant ALL and Down syndrome-associated leukemias. She investigates developmental stage-specific cellular programs to identify therapeutic targets. Recent publications emphasize: Leukemia modeling using genome editing EpiGenetic regulation in MLL-AF4 leukemia Multi-omics approaches to developmental stage-specific biology Scientific awards : Wellcome Trust Clinical Research Career Development Fellow MRC Investigator LLR Clinical Training Fellowship NIHR Academic Clinical Lectureship Bloodwise Clinician Scientist She leads DPhil projects on faithful ALL modeling, mechanistic studies, target discovery, and multi-omics. Her work aims to implement findings in low/middle-income countries and mentor clinician scientists.

Craig H. Bassingمشاهده پروفایل

استاد

• Immunology
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Craig H. Bassing, Ph.D. is a Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine, University of Pennsylvania, with a secondary affiliation at Children's Hospital of Philadelphia. His work focuses on molecular mechanisms in lymphocyte development and immune system regulation. Education: B.A. in Biology from Johns Hopkins University (1992), Ph.D. in Biology from Duke University (1997). Research Interests: Dr. Bassing investigates antigen receptor gene assembly , DNA damage responses , and feedback inhibition mechanisms in T and B cell development. His studies explore how chromatin folding , RAG endonuclease activity , and protein kinases like ATM regulate immune diversity and genomic stability. Publications: Recent work highlights roles for locus folding , Cyclin D3 , and RAG1 domains in enforcing monogenic TCR expression and allelic exclusion . Collaborative studies address V(D)J recombination pathways and ubiquitin ligase functions in immune cell maturation.

Michael L. Atchisonمشاهده پروفایل

استاد

• Transcription
• Epigenetics
• Lineage Development
• +۹ مورد دیگر

Michael L. Atchison is a Professor in the Department of Biomedical Sciences at the University of Pennsylvania School of Veterinary Medicine. His research focuses on the molecular mechanisms of transcriptional regulation, epigenetics, and lineage commitment in B and T cells. Education: Ph.D. in Cell and Molecular Biology from New York University School of Medicine (1983) B.S. in Biology from SUNY at Albany (1977) Research Interests: Atchison investigates how the transcription factor YY1 influences hematopoietic lineage plasticity through long-distance DNA interactions and epigenetic modifications. His work explores YY1's role in stabilizing B/T cell commitment, chromatin structure, and immunoglobulin gene regulation. Publications & Trends: Recent studies highlight YY1's impact on 3D chromatin architecture, X-chromosome inactivation dynamics, and oncogenic processes. His work spans immunology, molecular biology, and epigenetic mechanisms. Laboratory & Collaborations: Atchison's lab includes visiting scientists (Frank Wilkinson, Arindam Basu), research specialists (Suchita Hodawadekar), and research associates (Sarmistha Banerjee). He directs the NIH/Boehringer-Ingelheim Summer Research Program and the VMD|PhD Program.

• B Cell Immunology
• Autoimmunity
• Lupus Nephritis
• +۷ مورد دیگر

Marcus Clark is a Professor of Medicine at the University of Chicago's Pritzker School of Medicine, where he leads a research laboratory focused on B cell biology and autoimmunity. His work spans fundamental immunological mechanisms and translational applications in autoimmune diseases, particularly lupus nephritis. Dr. Clark's research centers on B cell antigen receptor (BCR) signaling and its role in cell fate decisions. In the bone marrow, his laboratory discovered the epigenetic reader BRWD1 as a critical regulator of immunoglobulin light chain gene recombination during B lymphopoiesis. More recently, his team demonstrated that the pre-BCR initiates an IRF4-CXCR4 feedforward loop that directly signals Ig-kappa recombination, fundamentally revising the canonical model of B cell development. In peripheral tissues, Dr. Clark has reshaped understanding of germinal center biology by identifying novel B cell populations within the dark zone that enable compartmentalization of core functions. His laboratory has developed innovative approaches combining deep machine learning with single-cell technologies to study in situ adaptive immune responses in human lupus nephritis. This bioinformatics platform achieves sensitivity and specificity approaching two-photon excitation microscopy while being applicable to human disease studies. Analysis of his 15 most recent publications reveals a consistent focus on B cell development mechanisms, germinal center organization, and translational applications in autoimmune kidney disease, with increasing integration of computational methods and single-cell technologies over time. Dr. Clark maintains an exceptionally robust research program with multiple active NIH grants including R01AI187357 (2025-2029) on BRWD1-mediated cohesin conversion in B cell biology and R01AI180222 (2024-2029) on using artificial intelligence to bridge human and murine lupus nephritis studies. He serves as Principal Investigator on the University of Chicago Autoimmunity Center of Excellence (U19AI082724, 2009-2024) and the Medical Scientist National Research Service Award (T32GM150375, 2023-2028). His laboratory has trained numerous researchers who have become prominent in the field, including Malay Mandal, Anthony Chang, and Kichul Ko. Dr. Clark's team has developed novel in vivo models and targeted in vitro studies that provide definitive insights into complex immunological processes, with particular emphasis on the molecular regulation of B cell development and function in health and autoimmune disease.

Peter Savageمشاهده پروفایل

استاد

• Cancer Immunology
• Immune Tolerance
• Regulatory T Cell Biology
• +۷ مورد دیگر

Peter Savage is a Professor in the Department of Pathology at the University of Chicago, focusing on the regulation of immune tolerance and anti-tumor immunity. His research program investigates the cellular and molecular mechanisms of regulatory T cells (Tregs) in cancer and autoimmunity. PhD in Cancer Biology from Stanford University (2000) Postdoctoral training at University of California Berkeley (2004) and Memorial Sloan-Kettering Cancer Center (2009) BS in Biochemistry from University of Virginia (1993) Major research projects include: Development and function of tumor-associated Tregs Antigen specificity in thymus-derived Tregs Role of Aire in immune tolerance Dendritic cell interactions with Tregs His publications (15 most recent) span topics in Treg biology, tumor immunology, and autoimmune disease mechanisms, with keywords including Immunology, Oncology, Cell Biology, and Autoimmune Diseases. Notable awards include the Damon Runyon Cancer Research Fund Postdoctoral Fellowship, Cancer Research Foundation Young Investigator Award, and Cancer Research Institute Investigator Award. Current research funding from NIH includes grants for studies on B cell-dependent Tregs, IL-10-producing Tr1 cells, and Treg suppression specificity during infections. He leads the Savage Lab, mentoring doctoral candidates in the University of Chicago's Committee on Immunology.