معرفی
Xuelin Lou, PhD, is a Professor in the Department of Cell Biology, Neurobiology and Anatomy at the Medical College of Wisconsin (MCW). He serves as Director of the Advanced Cell Imaging Core, leading cutting-edge imaging infrastructure. His research bridges neuroscience, cell biology, and biophysics, focusing on synaptic communication mechanisms and their dysfunction in neurodegenerative diseases (Alzheimer's/Parkinson's) and metabolic disorders like diabetes.
Key research areas include:
- Presynaptic vesicle trafficking and exocytosis-endocytosis coupling
- Insulin granule dynamics in pancreatic beta cells
- Super-resolution microscopy applications (PALM, STORM, STED)
- Phosphoinositide signaling in membrane trafficking
Methodologies employed:
- Single-molecule localization microscopy
- Live-cell imaging (TIRF/Confocal)
- Mouse genetics and disease models
- Optogenetics
- Electrophysiology (patch-clamp, capacitance measurements)
Recent publications emphasize dynamin protein roles in insulin secretion, synaptic plasticity, and phosphoinositide distribution at the nanoscale. His work highlights interdisciplinary approaches to uncover mechanisms underlying synaptic dysfunction and metabolic diseases.
Current initiatives include developing novel imaging tools and recruiting postdoctoral fellows with expertise in live-cell imaging, optogenetics, or molecular biology.
