Mark Mooseker

Mark Mooseker is a Ross Granville Harrison Professor of Molecular, Cellular, and Developmental Biology and Professor of Cell Biology at Yale University. His research focuses on the molecular and functional organization of the cytoskeleton, particularly actin-based molecular motors (myosins). He has identified and characterized multiple myosin classes, studying their roles in organelle transport, membrane trafficking, and cellular motility using mouse and Drosophila models. His work bridges cell biology, biophysics, and genetics to understand how myosins modulate cellular processes.

• Education: PhD in Cellular and Molecular Biology from the University of Pennsylvania (1976).
• Research Interests: Myosin structure/function, cytoskeletal dynamics, endocytosis/exocytosis, and disease-related myosin mutations.

Key collaborators include Jon Morrow, Paul Forscher, and Jorge Galán. His lab explores myosin roles in diverse contexts, such as CFTR trafficking in enterocytes and RNA-processing in yeast. Recent studies highlight myosin interactions with dynamin, synaptojanin-1, and other cellular components.

Publications span molecular mechanisms of myosin function, including their roles in immune cell motility, synaptic structure, and pathogen resistance. His findings contribute to understanding both basic cellular biology and potential therapeutic targets for myosin-related disorders.