معرفی
Edward Bonder serves as Professor of Cell Biology and Chair in the Department of Biological Sciences within the College of Arts and Sciences at Rutgers University-Newark. His laboratory investigates the structural and functional dynamics of the actin cytoskeleton across multiple biological contexts including morphogenesis, cell-cell contact formation, and organelle motility. Utilizing marine gamete models and cultured epithelial systems, his research bridges fundamental cell biology with developmental processes.
Education:
- B.A. in Biology, University of Pennsylvania (1976)
- Ph.D. in Cell Biology, University of Pennsylvania (1983)
Dr. Bonder's research focuses on actin-myosin interactions governing cellular dynamics, with particular emphasis on myosin motor proteins in fertilization models, adherens junction formation, and mitochondrial motility along cytoskeletal tracks. His work demonstrates how Rho GTPase signaling, microtubule-actin crosstalk, and unconventional myosins regulate cell polarization, wound healing, and embryonic development. The laboratory employs sea urchin coelomocytes and epithelial cell cultures to dissect stimulus-response mechanisms in organelle transport and cell adhesion.
Publication analysis reveals sustained contributions to cytoskeletal dynamics over 25+ years, with recent work expanding into cancer biology, stem cell regulation, and host-microbe interactions. Key themes include Rab11-dependent trafficking, CDC42-mediated tumor suppression, and TLR sorting mechanisms - all rooted in fundamental cytoskeletal principles established through earlier sea urchin and epithelial models.
No scientific awards are documented in the provided materials.
Dr. Bonder maintains active research programs examining cytoskeletal regulation in development and disease, with consistent funding evidenced by continuous publication in high-impact journals including PNAS, Journal of Cell Biology, and EMBO Journal. His laboratory trains researchers in advanced cell imaging, molecular perturbation techniques, and model system applications.
The research group operates from 309 Boyden Hall, utilizing sea urchin fertilization models, epithelial cell culture systems, and molecular approaches to investigate cytoskeletal dynamics across scales from single molecules to tissue organization. Current projects integrate traditional cell biology with emerging work in intestinal stem cells and microbial homeostasis.
