معرفی
Xu Shangde is a Research Fellow and Deputy Director at the Institute of Biochemistry, Academia Sinica. His research employs advanced biophysical techniques (NMR, cryo-EM) to investigate the structure-function relationships of biological macromolecules, with focus areas including protein folding mechanisms, viral spike protein dynamics, and cancer-related protein misfolding.
Education:
- Ph.D. in Biomolecular Research, Utrecht University, Netherlands (2000–2004)
- M.S. in Life Sciences, Tsinghua University (1998–2000)
- B.S. in Physics and Life Sciences (Double Major), Tsinghua University (1994–1998)
His laboratory integrates NMR spectroscopy with computational and biochemical methods to study: 1) Protein folding pathways, including knotted proteins; 2) Molecular mechanisms of viral infection (SARS-CoV-2, coronaviruses); 3) Oncogenic mutations in deubiquitinases like BAP1; and 4) Antimicrobial peptide interactions. Collaborative projects extend to pharmaceutical applications of structural insights.
Recent publications (2020–2025) demonstrate a strong emphasis on viral spike protein dynamics (75%), protein folding/topology (20%), and cancer biology (5%), with recurring methodological themes in NMR, cryo-EM, and molecular dynamics simulations.
