معرفی
S. Saif Hasan is an Associate Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine. His primary appointment is at the Center for Biomolecular Therapeutics (CBT) and Institute for Bioscience and Biotechnology Research (IBBR) in Rockville, MD. He leads a research group focused on structural biology of viral proteins and inter-organelle trafficking mechanisms.
- PhD in Biological Sciences, Purdue University (2013)
- Postdoctoral Research, Purdue University (2013-2019)
- M.Sc. in Biotechnology, University of Pune (2006)
- B.Sc. in Biochemistry, Aligarh Muslim University (2004)
His research employs Cryo-EM and X-ray crystallography to study viral hijacking of cellular trafficking pathways. Key projects include: SARS-CoV-2 spike protein trafficking, antibody neutralization mechanisms, and intra-cellular export of genetic vaccines. His work has direct implications for anti-viral therapeutics and vaccine optimization.
Recent publications analyze coronavirus spike protein structures (2023), therapeutic antibody interactions (2023), and retrograde trafficking dynamics (2022). These studies span structural biology techniques, membrane protein biochemistry, and virus-host communication pathways.
- Biophysical Society travel award (2019)
- Best post-doctoral talk at Purdue symposium (2018)
- Pre-Clerkship Teaching commendations (2022, 2023)
- Teaching of the Year (2024)
Hasan's team investigates how viruses like coronaviruses and flaviviruses exploit cellular highways for propagation. The lab collaborates on mass spectrometry, NMR, and computational protein design. They recently secured NIH R01 funding (2023-2028) for COPI-dependent trafficking research and R21 funding (2024-2026) for coronavirus spike protein studies.
