معرفی
Tom Deegan is a Programme Leader in the Institute of Genetics and Cancer at the University of Edinburgh. He leads a research group focused on understanding the molecular mechanisms of chromosome replication and genome stability in eukaryotes.
- Education: PhD in Biochemistry from University College London (2014), Master of Biochemistry from the University of Oxford (2010).
Deegan’s research centers on the replisome—a complex molecular machine responsible for DNA replication—and its regulation to ensure accurate genome inheritance. Key areas include:
- Replisome assembly and disassembly
- Helicase function in DNA replication
- Ubiquitin-mediated regulation of replication forks
- In vitro reconstitution of DNA replication systems
- Yeast and human genetic approaches
- Cryo-electron microscopy analysis
His recent publications highlight the role of accessory helicases (Rrm3, RTEL1) and ubiquitin thresholds in replisome disassembly. Collaborations include Dr. Joe Yeeles (MRC LMB), Dr. Jon Baxter (University of Sussex), and Prof. Adele Marston (Edinburgh).
The lab combines biochemistry, structural biology, and genetic studies to dissect replication fork progression and termination. Funding is provided by the Medical Research Council.
