جستجوی استاد راهنمای دانشگاهی

Rebecca Schulman is an Associate Professor in the Department of Chemical and Biomolecular Engineering at the Whiting School of Engineering, Johns Hopkins University. She holds secondary appointments in Chemistry and Computer Science and is affiliated with multiple interdisciplinary institutes, including the Institute for NanoBioTechnology, the Hopkins Extreme Materials Institute, the Chemistry-Biology Interface Program, the Center for Cell Dynamics, and the Laboratory for Computational Sensing and Robotics. She currently co-directs the Passport to Future Technology Leadership program for PhD students. Research Interests: Schulman's research lies at the intersection of DNA nanotechnology, synthetic biology, and smart materials. Her group develops intelligent, adaptive biomolecular materials and nanostructures by integrating concepts from materials science, biochemistry, circuit design, and soft matter physics. The team focuses on engineering dynamic self-assembly processes using DNA to create reconfigurable materials, molecular circuits, and autonomous soft micro-robots. Key themes include self-healing nanostructures, feedback-regulated crystallization, programmable hydrogels, and synthetic genetic networks for materials control. Publication Trends: Her recent publications demonstrate a consistent focus on using DNA-based chemical reaction networks to program spatial and temporal behavior in materials. The work spans from fundamental mechanisms like catalytic polymerization and crystal growth regulation to applications in soft robotics, self-wiring circuits, and synthetic pattern formation. The research is highly interdisciplinary, combining synthetic biology with materials engineering to achieve life-like functionalities in non-living systems. Scientific Awards: AIMBE Fellowship Award Vannevar Bush Faculty Fellowship Award Hartwell Individual Biomolecular Research Award President’s Early Career Award in Science and Engineering (PECASE) DARPA Young Faculty Award DARPA Directors Fellowship NSF CAREER Award Turing Scholar Award DOE Early Career Award Advising and Grants: Schulman mentors graduate students and leads a vibrant research group focused on next-generation biomolecular engineering. Her work is supported by major federal grants, including the NSF CAREER, DOE Early Career, DARPA, and the Vannevar Bush Fellowship—a prestigious Department of Defense award for basic research. She is actively involved in training future leaders through programs like the Passport to Future Technology Leadership. Labs and Teams: The Schulman Lab at Johns Hopkins is a multidisciplinary team working on DNA-powered materials and molecular programming. The lab is embedded within several collaborative centers, enabling strong cross-departmental and cross-institutional research. Their work combines experimental biochemistry with theoretical modeling to design and implement complex molecular systems.

• DNA Self-Assembly
• Smart Biomaterials
• Synthetic Biology
• +۷ مورد دیگر

Vilhelm Bohr is an Affiliate Professor at the Department of Cellular and Molecular Medicine , University of Copenhagen, affiliated with the Molecular Aging Program and Center for Healthy Aging . His research explores the interplay between DNA maintenance , mitochondrial biology , and aging , particularly in age-associated neurodegeneration and Alzheimer’s disease. Research Interests include: Molecular mechanisms linking NAD + metabolism to mitochondrial dysfunction and neurodegeneration Role of tau pathology in DNA damage and mitochondrial stress Impact of Aprataxin (APTX) and RECQL4 helicase defects on mitochondrial DNA integrity Pharmacological strategies to improve mitochondrial health via autophagy modulation Publications (2025-2024) span topics like NAD + biosynthesis, Werner/Rothmund-Thomson syndromes, tau nuclear functions, and mitochondrial turnover, with high citations and media attention. Collaborations extend to clinical tumor samples and CRISPR-based disease models.

• DNA Repair
• Mitochondrial Biology
• Aging
• +۵ مورد دیگر

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +۴ مورد دیگر

Ramesh Shanmughom Pillai is a Full Professor at the Department of Molecular Biology, University of Geneva, Switzerland. He holds additional roles as a Visiting Professor at the University of Kumamoto, Japan, and has been a Group Leader at EMBL Grenoble and a postdoctoral fellow at the Friedrich Miescher Institute. His research focuses on RNA modifications, epigenetics, and piRNA pathways in germline biology. Pillai has received prestigious awards including the ERC Consolidator Grant and The RNA Society Scaringe Award. Education: BSc Botany (University of Kerala, India) MSc Biotechnology (IIT Roorkee, India) PhD in Cell Biology (University of Bern, Switzerland) Research Interests: Pillai’s work centers on RNA biology, particularly the role of RNA modifications (e.g., m6A, m6Am) in development and fertility. He investigates piRNA biogenesis, transposon silencing, and the molecular mechanisms of RNA-protein interactions. His studies bridge biochemistry, genetics, and structural biology to elucidate how RNA molecules regulate critical biological processes. Teaching & Service: At the University of Geneva, he teaches Molecular Biology courses (BSc/MSc levels) and advises 5 PhD students and 4 postdocs. He chairs the ERC Consolidator Grant Review Panel and organizes major conferences like the PIWI/piRNAs Meeting and Swiss RNA Workshop. Pillai also serves on editorial boards for Nucleic Acids Research and RNA . Awards: ERC Consolidator Grant (2015) Best PhD Thesis Award (2003) RNA Society Scaringe Award (2005) Grants & Labs: Funded by ERC Starting and Consolidator Grants, his lab explores RNA modification networks in germ cells. Former trainees include Professors Simon Conn (Flinders University) and Hao Wu (CAS, China).

• Epigenetics
• RNA modifications
• miRNAs
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John Diffley is a Principal Group Leader and Associate Research Director at The Francis Crick Institute in London, UK, where he leads research on DNA replication mechanisms. His work focuses on understanding how cells precisely duplicate their DNA during cell division and how errors in this process contribute to cancer development. Diffley obtained his PhD from New York University in 1985 and completed postdoctoral training with Bruce Stillman at Cold Spring Harbor Laboratory until 1990. He established his research group at the Clare Hall Laboratories (originally Imperial Cancer Research Fund, then Cancer Research UK) before moving to The Francis Crick Institute in 2015. His research spans DNA replication initiation, cell cycle control, replication fork checkpoints, and epigenetic inheritance. Diffley's lab has pioneered methods to reconstitute chromatin replication using purified proteins, providing unprecedented insights into chromosome biology. His team combines genetics, cell biology, and biochemistry to study the molecular 'machines' that copy DNA in yeast and human cells. Analysis of Diffley's recent publications reveals a strong focus on structural mechanisms of DNA replication, particularly using cryo-EM to visualize replication machinery. His work examines helicase loading and activation, replication fork stability under stress, and the connection between replication errors and cancer development. The research spans model organisms to human cells, with increasing emphasis on structural approaches in recent years. FRS (Fellow of the Royal Society) FMedSci (Fellow of the Academy of Medical Sciences) Diffley actively mentors a diverse team of postdoctoral researchers and PhD students, investigating various aspects of DNA replication. His lab has received substantial funding to support their work on replication mechanisms, with projects spanning basic biochemical reconstitution to studies of replication errors in cancer contexts. The lab maintains multiple technical platforms including structural biology, biochemistry, and cell biology approaches. His research group operates within The Francis Crick Institute's collaborative environment, utilizing shared facilities for structural biology, microscopy, and genomics to advance understanding of DNA replication mechanisms and their implications for genome stability and disease.

• DNA Replication
• Cell Cycle Control
• Chromosome Biology
• +۵ مورد دیگر

Jeff S Abramson is a Professor of Physiology in the David Geffen School of Medicine at the University of California Los Angeles (UCLA). His research focuses on the structural and functional characterization of membrane transport proteins, particularly sugar transporters and mitochondrial channels. He maintains an active laboratory investigating the molecular mechanisms of cellular transport processes. Dr. Abramson's primary research interests center on membrane transport proteins, with particular emphasis on sugar symporters and voltage-dependent anion channels (VDACs). His work combines structural biology, biophysics, and biochemistry to understand the molecular mechanisms of transport, including conformational changes during transport cycles, substrate recognition, and regulation by membrane potential. His research has significant implications for understanding metabolic disorders, mitochondrial function, and potential therapeutic targets. Analysis of Dr. Abramson's publication record reveals a consistent focus on membrane protein structure-function relationships over the past two decades. His work demonstrates expertise in X-ray crystallography, cryo-electron microscopy, and functional assays to characterize transport proteins. Recent publications show increasing emphasis on mitochondrial biology, particularly VDAC structure and function, while maintaining his longstanding interest in sugar transport mechanisms. His research bridges fundamental biophysical principles with potential biomedical applications in metabolic diseases. Dr. Abramson has been awarded multiple NIH grants supporting his research, including the R35GM135175 grant titled 'Deciphering molecular details of cellular sugar transport and their roles in disease' (2020-2024), R01GM124783 'Functional and structural studies of unique pathogenic transporters involved in glycobiology' (2017-2021), and R01GM078844 'Structural and functional characterization of sugar transporters in health and disease' (2006-2020). As Principal Investigator, Dr. Abramson has mentored numerous graduate students and postdoctoral researchers. His laboratory has made significant contributions to understanding the structure-function relationships of membrane transport proteins through collaborations with researchers across multiple disciplines. The lab utilizes advanced techniques including X-ray crystallography, cryo-EM, electrophysiology, and computational modeling to address fundamental questions about membrane protein mechanisms. Dr. Abramson's laboratory is part of UCLA's broader research ecosystem focused on structural biology and membrane protein research. His work intersects with several research centers at UCLA including those focused on metabolic diseases and structural biology. The lab maintains active collaborations with researchers specializing in biophysics, computational modeling, and disease mechanisms to translate basic findings into potential biomedical applications.

• Membrane Transport Proteins
• Structural Biology
• Sugar Transporters
• +۵ مورد دیگر

Dr. Sheena D'Arcy is an Associate Professor in the Department of Chemistry and Biochemistry at the University of Texas at Dallas (UT Dallas), affiliated with the School of Natural Sciences and Mathematics. Her research focuses on structural biology, protein dynamics, and the molecular mechanisms of gene transcription, particularly involving histone chaperones and nuclear transport proteins. She holds a PhD in Structural Biology from the University of Cambridge (2008) and a BS in Biochemistry and Biology from the University of Sydney (2003). Her work employs advanced techniques like hydrogen-deuterium exchange mass spectrometry (HDX-MS) and structural biology to investigate protein-RNA interactions, nucleosome assembly, and enzyme evolution. She leads the D'Arcy Lab, which explores topics such as TRAMP complex function, RanGTP signaling in histone transport, and conserved viral epitopes in coronaviruses. Dr. D'Arcy received a NIH ESI-MIRA grant (R35GM133751) to study nucleosome assembly mechanisms. Her research bridges molecular-level interactions with cellular processes, contributing to understanding epigenetic regulation and viral pathogenesis. She is currently not accepting undergraduate students but actively mentors graduate researchers in structural biology and biochemistry.

• Structural Biology
• Gene Transcription Mechanisms
• Protein Dynamics
• +۳ مورد دیگر

Maria Hondele is a Tenure-track Assistant Professor at the Biozentrum, University of Basel, Switzerland, where she leads a research group dedicated to understanding the formation, regulation, and function of membraneless organelles, particularly those associated with RNA processing. Her interdisciplinary work bridges biochemistry, biophysics, and cell biology to dissect how RNA-protein condensates influence gene expression. Her research focuses on liquid-liquid phase separation and the role of DEAD-box ATPases as master regulators of biomolecular condensates. She investigates how these dynamic structures control RNA flux, processing, and localization within cells. Her lab employs a multidisciplinary approach including biochemical reconstitution, biophysical measurements, high-throughput screening, and advanced imaging techniques to uncover the molecular mechanisms underlying condensate formation and function. The recent publications of her group reveal a strong thematic focus on RNA-protein interactions, phase separation, stress granules, and the enzymatic regulation of condensates by ATPases. These studies span model systems from synthetic coacervates to human cells, reflecting a comprehensive strategy to understand both fundamental principles and biological implications of membraneless organelles. ERC Starting Grant (2020) SNSF Eccellenza Professorship (2019) HFSP Long-Term Postdoctoral Fellowship (2015–2018) ETH and EMBO Postdoctoral Fellowship (2015) PhD Prize, University of Munich (2014) Boehringer Ingelheim PhD Fellowship (2008–2011) Dr. Hondele advises a vibrant team of postdoctoral fellows, PhD students, and master’s students, indicating an active and expanding research program. She has secured competitive grants and leads a productive research group contributing significantly to the field of RNA biology and cellular organization. She is also an Associate Member of the National Center of Competence in Research (NCCR) RNA & Disease, reflecting her integration into major national research initiatives. Her research group is embedded within the Biozentrum, a leading interdisciplinary research center at the University of Basel, providing access to state-of-the-art facilities and collaborative networks in molecular and cellular biology.

• Membraneless Organelles
• Biomolecular Condensates
• Liquid-Liquid Phase Separation
• +۷ مورد دیگر

Feyruz V. Rassool is a Professor at the University of Maryland School of Medicine, with primary appointment in Radiation Oncology. She serves as Co-director of the Experimental Therapeutics Program at the University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC) and holds an adjunct Associate Professor position at VARI’s Center for Epigenetics. Her research focuses on DNA damage/repair pathways in cancer, particularly their therapeutic exploitation through PARP and DNMT inhibitors. Education: B.Sc. in Human Genetics (1983, University College London), Ph.D. in Biological Sciences (1990, Royal Postgraduate Medical School) Postdoctoral Training: University of Chicago (1990-1994) Her work explores the intersection of DNA repair , epigenetics , and mitochondrial dysfunction to develop novel therapies for breast, ovarian, lung, and leukemias. Key projects include STING-dependent interferon signaling , pathogen mimicry in cancer cells, and metastasis suppression through PARPi/epigenetic combinations. Dr. Rassool is part of the SU2C Epigenetics Dream Team and has secured multiple grants from NCI, NIH, and the Adelson Medical Research Foundation. Her recent preclinical studies with PARP/DNMT inhibitors are being translated into Phase I/II trials for AML and TNBC. Scientific Awards Ziskin Award (2012) NCI-SPORE Grant Co-Leader NIH/NCI P30 CA134274 Support Grant She has mentored 13 PhD/postgraduate researchers and collaborates on clinical trials with Pfizer, VARI-SU2C, and ASTRO. Her lab employs techniques like DNA repair assays , RNAseq , and mouse xenograft models to investigate mechanisms of action for epigenetic drugs.

• DNA damage and repair
• Genomic instability
• Epigenetic therapy
• +۷ مورد دیگر

Christopher D. Lima is a Professor and Chair of the Structural Biology Program at the Sloan Kettering Institute (SKI), Memorial Sloan Kettering Cancer Center (MSKCC), and an Investigator of the Howard Hughes Medical Institute. He holds the Alfred P. Sloan Chair. His research focuses on understanding the structural, biochemical, and functional mechanisms of macromolecules involved in post-translational protein modification by ubiquitin-like proteins (e.g., SUMO) and RNA processing pathways, including co- and post-transcriptional RNA maturation and decay. His lab employs cryo-electron microscopy (cryo-EM), X-ray crystallography, and biochemical reconstitution to study these processes. Education: PhD, 1994, Northwestern University BA, 1989, The Ohio State University Research Interests: Structural basis of ubiquitin and SUMO conjugation pathways Mechanisms of RNA surveillance and decay by the nuclear exosome Role of RNA processing in cell cycle control and disease Interactions between RNA helicases and exosome complexes Awards & Honors: Member, National Academy of Sciences (2020) Fellow of the American Academy of Arts and Sciences (2017) HHMI Investigator (2013) Louise and Allston Boyer Young Investigator (2006) Advising & Grants: Lima mentors numerous graduate students and postdoctoral researchers. His lab has received funding from the NIH, HHMI, and other institutions to support research into RNA processing and ubiquitin pathways. He collaborates widely, including with teams at MSKCC and other academic institutions. Labs & Teams: The Lima Lab is part of the Tri-Institutional PhD Program in Chemical Biology and the Gerstner Sloan Kettering Graduate School. The lab has made groundbreaking contributions to understanding SUMOylation and RNA exosome mechanisms, with key findings published in Nature , Cell , and Science .

• Structural Biology
• Biochemistry
• Macromolecular Structure
• +۶ مورد دیگر

Professor Tracy Bryan is a Professor in the Faculty of Medicine and Health at the University of Sydney and serves as Unit Head of the Cell Biology Unit at the Children's Medical Research Institute (CMRI). She holds a Bachelor of Science from Macquarie University and a PhD from the CMRI, where her groundbreaking research identified the ALT (Alternative Lengthening of Telomeres) mechanism in cancer cells. After postdoctoral work with Nobel Laureate Tom Cech at the University of Colorado, she returned to Australia in 2001 to establish her research group at CMRI. Her research focuses on telomerase biology, particularly its role in cancer progression and bone marrow failure syndromes. Key themes include understanding telomerase mechanisms, developing inhibitors for cancer therapy, and investigating telomere biology disorders. Her work integrates biochemical and cell-based approaches, supported by grants from NHMRC, Viertel Foundation, and Cancer Council NSW. Recent publications highlight advancements in telomerase-substrate interactions, i-motif DNA structures, and the interplay between telomere maintenance and DNA damage responses. Major grants include NHMRC Ideas Grants targeting telomere-related bone marrow failure and ARC Discovery Projects exploring DNA replication-telomere links. Bryan’s research group collaborates internationally, contributing to translational studies in oncology and regenerative medicine. Her lab’s work is detailed at CMRI’s Cell Biology Team page, with ongoing projects focused on telomerase inhibition strategies and molecular mechanisms of telomere dysfunction.

• Cancer Biology
• Biochemistry
• Telomere Biology
• +۴ مورد دیگر

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution. Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles. Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.

• Computational Genomics
• Gene Regulation
• RNA Biology
• +۴ مورد دیگر

Duncan J Clarke is a Professor in the Department of Genetics, Cell Biology and Development at the University of Minnesota Medical School. His research focuses on the molecular mechanisms of chromosome segregation during cell division, with particular emphasis on the role of DNA topoisomerases and related proteins. Dr. Clarke's research interests include: Mechanisms of chromosome segregation during mitosis Function of DNA topoisomerase II in centromere and kinetochore regulation Role of SUMOylation in chromosome dynamics Spindle assembly checkpoint mechanisms Interactions between histone modifications and chromosome segregation machinery Connections between DNA topology and cell division His recent publications reveal a strong focus on the molecular details of chromosome segregation, particularly examining how DNA topoisomerases, histone modifications, and microtubule dynamics coordinate to ensure accurate chromosome distribution during cell division. His work bridges basic molecular mechanisms with potential clinical applications in cancer therapy, as evidenced by his research on topoisomerase inhibitors. Dr. Clarke has received significant research funding from NIH, including: Control of Chromosome Segregation by DNA Topoisomerase II (2024-2028) A high-throughput screen for inhibitors of Plk1-interacting checkpoint helicase (PICH) (2022-2025) Multiple previous NIH-funded projects dating back to 2003 His laboratory utilizes both yeast and mammalian model systems to investigate fundamental mechanisms of chromosome segregation that are conserved across species, with potential implications for understanding cancer development and improving cancer therapies.

• Chromosome Segregation
• DNA Topoisomerase
• Mitosis
• +۷ مورد دیگر

Dr. Steven Jacobsen is a Professor in the Molecular, Cell, and Developmental Biology Department at the University of California, Los Angeles (UCLA), where he leads the Jacobsen Lab. His work focuses on epigenetic inheritance and gene regulation in Arabidopsis thaliana and mammalian stem cells, utilizing genetic screens, genomics, epigenomics, and biochemical approaches. The lab also pioneers CRISPR-mediated genome editing techniques. University: University of California, Los Angeles Department: Molecular, Cell, and Developmental Biology Research Interests: Jacobsen's research spans multiple interconnected domains in epigenetics, including DNA methylation patterning, histone modification interplay, and transposable element silencing. His team investigates how chromatin structure influences gene expression and epigenetic inheritance, with applications from plant development to human health. Key areas include: CRISPR-based epigenetic modifications RNA-directed DNA methylation (RdDM) mechanisms Chromatin compaction via MORC proteins Histone variant functions in methylation Transposon control in plant genomes Comparative epigenomics across species Advising Legacy: Over two decades, Dr. Jacobsen has mentored 21 former lab members who now hold academic and industry positions globally, including professors at Chinese Academy of Sciences, University of Georgia, and Southern University of Science & Technology. His lab's publications reveal a consistent focus on DNA methylation dynamics, chromatin remodeling, and small RNA pathways, with recent work emphasizing CRISPR innovations and structural insights into epigenetic regulators.

• Epigenetics
• Epigenomics
• Genetics
• +۴ مورد دیگر

Hans-Guido Wendel is an Associate Professor at the Graduate School of Medical Sciences, Weill Cornell Medicine, and a Member at the Sloan-Kettering Institute. His research is centered on uncovering biological vulnerabilities in cancer cells, particularly in aggressive lymphomas and leukemias, to develop novel therapeutics. His research interests span several critical areas in cancer biology, including: Immune receptor signaling in lymphoma Oncogenic RNA translation programs Epigenetic and transcriptional regulation in cancer Metabolic control of gene expression CRISPR-based discovery of cancer dependencies He leverages cutting-edge tools such as unbiased CRISPR/Cas9 screens and patient-derived xenograft models to validate therapeutic targets. The trends in his research, as reflected in key publications, emphasize the translation of molecular discoveries into clinical strategies. His work bridges basic mechanisms—such as glucose-regulated transcription and RNA helicase function—with therapeutic innovation, including small molecule inhibitors and engineered immune cells like CAR T 'micro-pharmacies'. These efforts highlight a consistent focus on target identification and validation in hematologic malignancies. Scientific recognition includes: National Cancer Institute Outstanding Investigator Dr. Wendel leads an active research program supported by institutional and federal funding. His lab mentors trainees and collaborates across disciplines to advance cancer therapeutics. Though no specific students are listed, his team conducts high-impact research in target discovery and preclinical validation. Future work includes developing inhibitors for glucose-regulated transcription and refining immune cell engineering for solid and hematologic tumors. His laboratory, known as the VIVO Lab, operates at the interface of molecular oncology and translational medicine, contributing to both fundamental understanding and therapeutic innovation in cancer biology.

• Cancer Biology
• Lymphoma
• Leukemia
• +۷ مورد دیگر