معرفی
Judith L. Campbell is a Professor of Chemistry and Biology at California Institute of Technology (Caltech), with a distinguished career spanning decades. She earned her BA from Wellesley College in 1965 and her PhD from Harvard University in 1974. Joining Caltech in 1977, she advanced from Assistant Professor to full Professor by 1989, maintaining her position thereafter. Her research focuses on DNA replication, repair, and genomic stability, utilizing yeast genetics, Xenopus egg extracts, and human cell studies.
Her work explores the critical role of DNA helicases like DNA2 in maintaining genome integrity, particularly under replication stress. She investigates how defects in these proteins contribute to cancer and premature aging syndromes, such as Werner and Bloom syndromes, and their interaction with pathways like homologous recombination and non-homologous end-joining. Her lab has pioneered biochemical reconstitution of recombination machinery in yeast and human cells.
Publications highlight her expertise in DNA2 nuclease/helicase functions, replication fork dynamics, and the impact of helicase mutations on disease. She has contributed to understanding chemotherapy resistance mechanisms and the role of post-translational modifications (e.g., TRAF6-mediated ubiquitination) in DNA2 regulation.
In teaching, she co-instructs Bi/Ch 111 (Biochemistry of Gene Expression), covering DNA replication, transcription, RNA processing, and protein synthesis. Her research provides foundational insights into DNA metabolism, offering potential therapeutic targets for cancer and aging-related disorders.
