Yuliang Wu

Dr. Yuliang Wu is a Professor of Biochemistry at the University of Saskatchewan, specializing in DNA repair mechanisms and genomic stability. He holds a Ph.D. from the International Centre for Genetic Engineering and Biotechnology (ICGEB), India, and completed postdoctoral training at the University of Alberta and NIH. His research focuses on helicases (FANCJ, ChlR1, RTEL1) and their roles in cancer, genetic disorders, and aging. Key areas include G-quadruplex resolution, innate immunity activation via DDX41, and synthetic lethality targets in cancer therapy.

Research Interests: Cancers linked to DNA repair defects (breast, ovarian), genetic syndromes (Fanconi anemia, Warsaw breakage), helicase functions in replication stress, and immune responses to viral DNA. Current projects involve DDX43's role in mRNA splicing and RTEL1's telomere regulation.

Publications emphasize helicase biochemistry, synthetic lethality in cancer, and mechanistic insights into DNA repair pathways. Collaborations include functional studies on FANCJ's role in resolving replication barriers and DDX41's cGAS-STING activation during viral infection.