Michael Ewers

Michael Ewers is a Professor at LMU Munich and leads the Ewers Lab at the Graduate School of Systemic Neurosciences, Institute for Stroke and Dementia Research (ISD). His research focuses on Alzheimer’s disease (AD) progression, combining neuroimaging (MRI, PET), genetics, and biofluid analyses to model spatiotemporal tau and beta-amyloid evolution. He investigates cognitive resilience mechanisms, including brain network efficiency and myelin integrity, aiming to advance precision medicine in AD.

• Primary research areas: Biomedical Neuroscience, Behavioral & Cognitive Neuroscience
• Key methods: human MRI, molecular PET, biostatistics
• Selected subfields: Tau pathology spread, genetic modulators (MAPT, Klotho, BIN1), myelin changes, amyloid co-pathology

The Ewers Lab team includes postdoctoral researchers (e.g., Yuanxi Li) and PhD students (e.g., Reihaneh Ahmadi, Jannis Denecke, Carolina Valentim), who explore vascular mechanisms, genetic risk factors, and network dynamics in AD. Publications highlight collaborations with international consortia like Alzheimer’s Disease Neuroimaging Initiative and Dominantly Inherited Alzheimer Network.

Recent work (2025–2020) emphasizes:

• Patient-level prediction of tau pathology via functional connectomics
• Myelin’s role in accelerating tau accumulation
• Genetic SNPs (BIN1, Klotho) modulating AD progression
• Cognitive reserve mechanisms in frontal networks
• Integration of biomarkers (sTREM2, amyloid PET) for clinical prognosis