Xi Chen

Dr. Xi Chen is an Assistant Professor in the Department of Integrative Neuroscience at Stony Brook University. He holds a Ph.D. from the University of Texas at Dallas (2019). His research focuses on cognitive aging, Alzheimer’s disease (AD) biomarkers, and the interplay between brain structure/function and cognitive decline. Dr. Chen employs multi-modal neuroimaging techniques (e.g., MRI, PET) to investigate neural mechanisms underlying age-related cognitive changes and AD progression. His work emphasizes early detection of AD pathology and resilience factors in aging populations.

Education:

• Ph.D., University of Texas at Dallas, 2019

Research Interests:

Dr. Chen explores individual differences in cognitive aging, AD biomarkers, and successful aging through multi-modal approaches. Key topics include amyloid and tau pathology’s impact on memory and brain function, socioeconomic disparities in cognitive health, and the role of prior knowledge in memory retention. His lab uses advanced imaging techniques to identify early biomarkers for interventions targeting neurodegenerative diseases.

Publications Trends:

Recent studies highlight the lab’s focus on tau pathology’s role in cognitive decline, functional MRI correlates of memory in aging populations, and the predictive value of biomarkers like plasma p-tau217 for AD progression. These works underscore the lab’s commitment to bridging basic neuroscience and clinical applications for early AD detection.

Lab & Collaborations:

Dr. Chen leads the Cognitive Health and Neurodegeneration Lab, which integrates quantitative modeling, neuroimaging, and clinical data to advance understanding of aging and AD. Collaborative efforts include studies on metacognition, cortical thickness, and tauopathy’s effects on cognition.