Nicolai Franzmeier

Nicolai Franzmeier is a Junior Research Group Leader at the Institute for Stroke and Dementia Research at LMU University Hospital. His research focuses on Alzheimer's disease, specifically the spatiotemporal evolution of neurodegeneration and mechanisms of cognitive resilience, combining advanced neuroimaging techniques like tau-PET and MRI connectomics with genetic analyses to develop personalized prediction models for disease progression.

Education:

• Psychology and Medicine (2009-2014), University of Innsbruck
• PhD (2017), Graduate School for Systemic Neurosciences, LMU Munich

Research Interests: Dr. Franzmeier investigates how tau pathology spreads in Alzheimer's disease using connectivity-based models, explores genetic modifiers like BIN1 and BDNFVal66Met, and identifies protective brain mechanisms against cognitive decline. His work has clinical applications in tau-targeting trials and differential diagnosis of tauopathies.

Article Trends: His recent publications emphasize multimodal neuroimaging (tau-PET, amyloid-PET, MRI) for tau spread prediction, microglial activation interactions, and vascular-cognitive interactions in Alzheimer's and related dementias. Collaborations span Alzheimer's Disease Neuroimaging Initiative (ADNI) and German Imaging Initiative for Tauopathies (GII4T).

Team Leadership: He mentors a team of postdoctoral researchers and PhD students working on topics such as tau-PET quantification, small vessel disease, and machine learning applications in neurodegenerative disease. His lab integrates clinical neuroscience with computational approaches to advance precision medicine in dementia.