Katherine S Bridge

Dr Katherine S Bridge serves as Lecturer in the Department of Biology at the University of York, leading the Bridge Lab within the Centre for Blood Research. Awarded the Kay Kendall Leukaemia Fund Intermediate Fellowship in 2021 and previously holding a Centre for Future Health fellowship (Wellcome Trust ISSF), her research investigates context-dependent roles of Hypoxia Inducible Factor (HIF) in cancer progression and hematopoiesis.

Her academic foundation includes:

• PhD in Molecular Mechanisms of HIF from University of Nottingham

Bridge's laboratory examines HIF's dual oncogenic/tumor-suppressive functions across solid tumors and hematological malignancies, with particular focus on non-hypoxic activation pathways in hematopoietic stem cells. Current work identifies molecular switches determining HIF functionality to develop targeted therapeutic interventions for treatment-resistant cancers.

Publication trends reveal consistent mechanistic exploration of HIF-LIMD1 interactions since 2012, evolving from foundational degradation studies to feedback loop analyses in tumor microenvironments (2018) and RNA regulatory networks (2017), demonstrating expanding expertise from solid cancers to blood malignancies.

Key recognitions:

• Centre for Future Health fellowship (Wellcome Trust ISSF, 2019)
• Kay Kendall Leukaemia Fund Intermediate Fellowship (2021)

As principal investigator, Bridge mentors postdoctoral researchers including Dr David Kealy and secures major grants like the MRC-funded 'Targeting sodium signalling' project (2023-2026). She actively advocates for parental retention in academia through UKRI's Early Career Researcher forum and Women in Research networks.

The Bridge Lab collaborates with York's Centre for Blood Research and international consortia, with Bridge serving on advisory committees for the International Society for Experimental Hematology (2023-2028) and European Haematology Association (2023-2028).