Nicholas Crump

Nicholas Crump is a Kay Kendall Leukaemia Fund Intermediate Fellow in the Department of Immunology and Inflammation at Imperial College London's Faculty of Medicine. His research focuses on epigenetic mechanisms underlying multiple myeloma, particularly enhancer dysregulation and drug resistance. He leads the Crump Lab, part of the Hugh and Josseline Langmuir Centre for Myeloma Research and the Centre for Haematology.

Key research areas include chromatin biology, oncogenic enhancer activity, and therapeutic target identification. Techniques used include ChIP-seq, ATAC-seq, and Micro-Capture-C, with a focus on optimizing methods like TOPmentation for patient sample analysis.

Crump's work addresses mechanisms of drug resistance in myeloma, aiming to reverse resistance through epigenetic干预. He has secured funding from the Kay Kendall Leukaemia Fund, Blood Cancer UK, and the Royal Society. His team includes PhD students Jinglin Zhou and Sophie Ball, as well as clinical researchers like Dr. Katrina Fordwor.

Recent publications explore enhancer function in leukemia, propionate metabolism's epigenetic impact, and immune graft dynamics in myeloma treatment. He advocates for translating epigenetic insights into novel therapies for blood cancers.