معرفی
James West is a Professor of Medicine and Associate Professor of Biomedical Engineering at Vanderbilt University's School of Engineering. His research focuses on pulmonary vascular disease, heart disease, and the biomechanics of the vasculature and right ventricle. He employs genetically modified animal models to study disease mechanisms and therapeutic interventions. Key areas include pulmonary hypertension, right ventricular failure, and metabolic dysregulation in cardiovascular disorders.
His work integrates molecular biology, genomics, and bioengineering approaches, such as single-cell RNA sequencing and hydrogel-based vascular engineering. Notable contributions include elucidating TBX4's role in pulmonary hypertension, ACE2-Mas1 receptor signaling pathways, and the therapeutic potential of ifetroban in systemic sclerosis and cardiac fibrosis.
Dr. West's research spans translational studies, including clinical trial investigations of metformin in PAH and the development of novel anti-fibrotic therapies. His findings have been published in high-impact journals and patents, emphasizing both basic science and clinical applications.
