معرفی
Jackson Taylor is an Assistant Professor at Cleveland State University's Center for Gene Regulation in Health and Disease (GRHD), leading research on epigenetic mechanisms of aging using Drosophila melanogaster models. His work focuses on how epigenetic modifications drive age-related dysfunction and disease, with emphasis on lifespan extension strategies.
Education:
- Ph.D. in Neuroscience, Wake Forest University School of Medicine (2013)
- Postdoctoral Training, Wake Forest Health Sciences (2013-2016)
- Postdoctoral Training, Brown University (2016-2022)
Dr. Taylor's research program investigates epigenome dynamics during aging, particularly how experimental manipulation of epigenetic regulators like Sirt6 extends lifespan and preserves physical function. His lab employs next-generation sequencing, bioinformatics, genetic engineering, and longevity assays to study Alzheimer's disease models and identify novel epigenetic modifiers. Key findings demonstrate that Sirt6 overexpression represses Myc target genes through H3K9ac deacetylation, reducing protein synthesis and extending lifespan in fruit flies.
Analysis of his publication record reveals consistent focus on epigenetic aging mechanisms across model systems, with significant contributions to understanding transposable element regulation, DNA methylation patterns in immune aging, and calcium channel dynamics in sarcopenia. His work bridges basic epigenetic discovery with translational applications for age-related diseases.
Dr. Taylor advises graduate students in the Taylor Lab (established Fall 2022), mentoring Samira Xhaferi, Roja Sharma, and Prema Singaravel. His research is supported through GRHD center resources and collaborations with the Cleveland Clinic Joint Ph.D. Programs.
The Taylor Lab operates within CSU's Science and Research Building (Room 259), utilizing advanced genomic and bioinformatic infrastructure through the GRHD center's facilities. Current projects target tissue-specific Sirt6 mechanisms in Alzheimer's disease models and high-throughput screening of epigenetic longevity modifiers.
