معرفی
Dr. Jingqi Yan serves as an Assistant Professor at the Center for Gene Regulation in Health and Disease (GRHD) within the College of Arts and Sciences at Cleveland State University. Her research laboratory, located in the Science and Research Building (Room 260), investigates molecular mechanisms linking autophagy and extracellular vesicles to neural circuit dysfunction in neurological disorders. Contact: j.yan37@csuohio.edu.
Research Focus
Dr. Yan's work centers on how autophagy and extracellular vesicles regulate synaptic transmission and neural circuits controlling sensory processing, cognition, and behavior. Her lab develops therapeutic strategies for cognitive and social deficits in autism, stroke, and age-related neurological diseases. Key methodologies include mouse models of Fragile X syndrome, molecular autophagy assays, and neural circuit mapping, with emphasis on translational applications for currently intractable conditions.
Publication Analysis
Dr. Yan's 11 publications (2007-2023) reveal progressive specialization from neuroprotective compounds (e.g., green tea polyphenols in Parkinson's models) to mechanistic studies of autophagy in neural dysfunction. Recent work (2021-2023) explores hypothalamic regulation of aging, vascular changes in diabetes, and Fragile X pathophysiology, appearing in high-impact journals including Nature, PNAS, and Cell Reports. Cross-cutting themes include RNA stress responses, exosomal miRNA signaling, and metabolic-neural interactions.
Scientific Recognition
- No specific awards or fellowships were documented in the provided materials
Research Leadership
Dr. Yan directs a neuroscience laboratory at GRHD with Research Assistant Professor Dr. Zyan Zhang. While formal student mentorship isn't detailed, her collaborative publications indicate training of junior researchers. Sustained publication output suggests ongoing grant support, potentially through CSU internal mechanisms or federal sources like NIH, though specific funding isn't mentioned.
Research Environment
Based in GRHD's collaborative infrastructure, Dr. Yan leverages CSU's partnership with the Cleveland Clinic for translational neuroscience. The center provides advanced core facilities for molecular analysis, enabling investigation of autophagy pathways and neural circuit dynamics in disease models, with future work targeting clinical applications for neurological disorders.
