معرفی
Isabelle Deschenes is a Professor and Chair in the Department of Physiology & Cell Biology at The Ohio State University. Her research focuses on the molecular mechanisms underlying cardiac arrhythmias, particularly the roles of ion channels (e.g., sodium, potassium) and their accessory subunits in regulating cardiac excitability. She employs electrophysiological, biochemical, and imaging techniques to study inherited channelopathies and heart failure-related arrhythmias. Her work includes using patient-derived induced pluripotent stem cells (iPSCs) to identify genetic modifiers influencing disease severity.
Education: PhD from Laval University, Canada (Quebec City), followed by postdoctoral training at Johns Hopkins University.
Research Interests: Her lab investigates ion channel structure-function relationships, mechanisms of incomplete penetrance in channelopathies, and the role of KChIP2 in regulating cardiac excitability through multimodal approaches (e.g., transcriptional regulation of miRNAs). Key topics include sodium channel trafficking, arrhythmia pathogenesis, and therapeutic targeting of ion channels.
Articles: Recent studies highlight structural insights into sodium channels, microRNA regulation of cardiac function, and the impact of genetic variants on ion currents. Her work bridges basic science with translational applications, such as iPSC-based modeling of inherited arrhythmias.
Labs/Teams: Leads a research group focused on molecular cardiology and arrhythmia mechanisms, collaborating on projects involving electrophysiology, genetics, and stem cell biology.
