Alan L Goldin

Alan L. Goldin, MD, PhD, is a Professor in three departments at the University of California, Irvine (UCI) School of Medicine: Anatomy & Neurobiology, Microbiology & Molecular Genetics, and Physiology & Biophysics. His research focuses on voltage-gated sodium channels and their roles in neurological disorders, particularly epilepsy and genetic channelopathies. Goldin's work explores the biophysical properties of these channels, their mutations linked to diseases like SCN1A-associated epilepsy, and their interactions with drugs and toxins.

His studies emphasize the molecular mechanisms underlying channel function, including inactivation processes, pharmacological modulation, and the effects of genetic mutations on neuronal excitability. He has contributed significantly to understanding how sodium channel dysfunction contributes to conditions such as febrile seizures, autism spectrum disorders, and cardiac arrhythmias. Goldin's research integrates electrophysiological, genetic, and pharmacological approaches, often using animal models to study disease mechanisms.

Publications highlight his work on sodium channel β subunits, drug-induced channel blockades, and the functional consequences of SCN8A mutations in neurological disorders. His findings have implications for drug safety, epilepsy treatment, and the development of targeted therapies for channelopathies. Goldin's interdisciplinary approach bridges basic science and clinical applications, with a focus on translating molecular insights into therapeutic strategies.